Search Results - "Atkinson, Gemma Catherine"
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ABCF ATPases Involved in Protein Synthesis, Ribosome Assembly and Antibiotic Resistance: Structural and Functional Diversification across the Tree of Life
Published in Journal of molecular biology (23-08-2019)“…Within the larger ABC superfamily of ATPases, ABCF family members eEF3 in Saccharomyces cerevisiae and EttA in Escherichia coli have been found to function as…”
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The evolutionary and functional diversity of classical and lesser-known cytoplasmic and organellar translational GTPases across the tree of life
Published in BMC genomics (14-02-2015)“…The ribosome translates mRNA to protein with the aid of a number of accessory protein factors. Translational GTPases (trGTPases) are an integral part of the…”
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Macrolide antibiotics allosterically predispose the ribosome for translation arrest
Published in Proceedings of the National Academy of Sciences - PNAS (08-07-2014)“…Translation arrest directed by nascent peptides and small cofactors controls expression of important bacterial and eukaryotic genes, including antibiotic…”
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RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis
Published in Molecular cell (05-08-2021)“…RelA-SpoT Homolog (RSH) enzymes control bacterial physiology through synthesis and degradation of the nucleotide alarmone (p)ppGpp. We recently discovered…”
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FlaGs and webFlaGs: discovering novel biology through the analysis of gene neighbourhood conservation
Published in BIOINFORMATICS (09-06-2021)“…Abstract Summary Analysis of conservation of gene neighbourhoods over different evolutionary levels is important for understanding operon and gene cluster…”
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Elevated levels of VCA0117 (VasH) in response to external signals activate the type VI secretion system of Vibrio cholerae O1 El Tor A1552
Published in Environmental microbiology (01-10-2020)“…Summary The type VI nanomachine is critical for Vibrio cholerae to establish infections and to thrive in niches co‐occupied by competing bacteria. The genes…”
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A Comprehensive Resource for Exploring Antiphage Defense: DefenseFinder Webservice,Wiki and Databases
Published in Peer community journal (25-09-2024)Get full text
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