Search Results - "Atkins, Janice L"

Muscle loss and obesity: the health implications of sarcopenia and sarcopenic obesity by Wannamethee, S. Goya, Atkins, Janice L.

“…This paper reviews the health implications of obesity, sarcopenia and sarcopenic obesity on CVD and mortality in older adults and discusses the obesity paradox…”
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Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort by Atkins, Janice L, Masoli, Jane A H, Delgado, Joao, Pilling, Luke C, Kuo, Chia-Ling, Kuchel, George A, Melzer, David

“…Abstract Background Hospitalized COVID-19 patients tend to be older and frequently have hypertension, diabetes, or coronary heart disease, but whether these…”
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Sarcopenic Obesity and Risk of Cardiovascular Disease and Mortality: A Population-Based Cohort Study of Older Men by Atkins, Janice L., Whincup, Peter H., Morris, Richard W., Lennon, Lucy T., Papacosta, Olia, Wannamethee, S. Goya

“…Objectives To examine associations between sarcopenia, obesity, and sarcopenic obesity and risk of cardiovascular disease (CVD) and all‐cause mortality in…”
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Red cell distribution width and common disease onsets in 240,477 healthy volunteers followed for up to 9 years by Pilling, Luke C, Atkins, Janice L, Kuchel, George A, Ferrucci, Luigi, Melzer, David

“…Higher Red Blood Cell Distribution Width (RDW or anisocytosis) predicts incident coronary artery disease (CAD) plus all-cause and cardiovascular mortality, but…”
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Nutrition and Frailty: Opportunities for Prevention and Treatment by Ni Lochlainn, Mary, Cox, Natalie J, Wilson, Thomas, Hayhoe, Richard P G, Ramsay, Sheena E, Granic, Antoneta, Isanejad, Masoud, Roberts, Helen C, Wilson, Daisy, Welch, Carly, Hurst, Christopher, Atkins, Janice L, Mendonça, Nuno, Horner, Katy, Tuttiett, Esme R, Morgan, Yvie, Heslop, Phil, Williams, Elizabeth A, Steves, Claire J, Greig, Carolyn, Draper, John, Corish, Clare A, Welch, Ailsa, Witham, Miles D, Sayer, Avan A, Robinson, Sian

“…Frailty is a syndrome of growing importance given the global ageing population. While frailty is a multifactorial process, poor nutritional status is…”
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Biological Aging Predicts Vulnerability to COVID-19 Severity in UK Biobank Participants by Kuo, Chia-Ling, Pilling, Luke C, Atkins, Janice L, Masoli, Jane A H, Delgado, João, Tignanelli, Christopher, Kuchel, George A, Melzer, David, Beckman, Kenneth B, Levine, Morgan E

“…Abstract Background Age and disease prevalence are the 2 biggest risk factors for Coronavirus disease 2019 (COVID-19) symptom severity and death. We therefore…”
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MRI-derived brain iron, grey matter volume, and risk of dementia and Parkinson's disease: Observational and genetic analysis in the UK Biobank cohort by Casanova, Francesco, Tian, Qu, Williamson, Daniel S., Qian, Yong, Zweibaum, David, Ding, Jun, Atkins, Janice L., Melzer, David, Ferrucci, Luigi, Pilling, Luke C.

“…Iron overload is observed in neurodegenerative diseases, especially Alzheimer's disease (AD) and Parkinson's disease (PD). Homozygotes for the iron-overload…”
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HFE genotypes, haemochromatosis diagnosis and clinical outcomes at age 80 years: a prospective cohort study in the UK Biobank by Lucas, Mitchell R, Atkins, Janice L, Pilling, Luke C, Shearman, Jeremy D, Melzer, David

“…ObjectivesHFE haemochromatosis genetic variants have an uncertain clinical penetrance, especially to older ages and in undiagnosed groups. We estimated p.C282Y…”
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Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers by Pilling, Luke C, Atkins, Janice L, Duff, Michael O, Beaumont, Robin N, Jones, Samuel E, Tyrrell, Jessica, Kuo, Chia-Ling, Ruth, Katherine S, Tuke, Marcus A, Yaghootkar, Hanieh, Wood, Andrew R, Murray, Anna, Weedon, Michael N, Harries, Lorna W, Kuchel, George A, Ferrucci, Luigi, Frayling, Timothy M, Melzer, David

“…Variability in red blood cell volumes (distribution width, RDW) increases with age and is strongly predictive of mortality, incident coronary heart disease and…”
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Diet quality in older age: the influence of childhood and adult socio-economic circumstances by Atkins, Janice L., Ramsay, Sheena E., Whincup, Peter H., Morris, Richard W., Lennon, Lucy T., Wannamethee, S. Goya

“…Socio-economic gradients in diet quality are well established. However, the influence of material socio-economic conditions particularly in childhood, and the…”
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Hemochromatosis Genetic Variants and Musculoskeletal Outcomes: 11.5‐Year Follow‐Up in the UK Biobank Cohort Study by Banfield, Lucy R., Knapp, Karen M., Pilling, Luke C., Melzer, David, Atkins, Janice L.

“…ABSTRACT The iron overload disorder hemochromatosis is primarily caused by the homozygous HFE p.C282Y variant, but the scale of excess related musculoskeletal…”
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Sarcopenic obesity in ageing: cardiovascular outcomes and mortality by Atkins, Janice L., Wannamathee, S. Goya

“…Obesity is a major public health issue with prevalence increasing worldwide. Obesity is a well-established risk factor for CVD and mortality in adult…”
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APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort by Kuo, Chia-Ling, Pilling, Luke C, Atkins, Janice L, Masoli, Jane A H, Delgado, João, Kuchel, George A, Melzer, David

“…The novel respiratory disease COVID-19 produces varying symptoms, with fever, cough, and shortness of breath being common. In older adults, it has been found…”
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Sarcopenic Obesity and Cardiometabolic Health and Mortality in Older Adults: a Growing Health Concern in an Ageing Population by Wannamethee, Sasiwarang Goya, Atkins, Janice L.

“…Purpose of Review Sarcopenic obesity (SO) is a growing public health problem in older adults. Whether SO confers higher risk of cardiometabolic disease and…”
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Genetic modifiers of penetrance to liver endpoints in HFE hemochromatosis: Associations in a large community cohort by Pilling, Luke C., Atkins, Janice L., Melzer, David

“…Background The iron overload condition hereditary hemochromatosis (HH) can cause liver cirrhosis and cancer, diabetes, and arthritis. Males homozygous for the…”
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Incidence of liver complications with hemochromatosis associated HFE p.C282Y homozygosity: The role of central adiposity by Lucas, Mitchell R, Pilling, Luke C, Atkins, Janice L, Melzer, David

“…The HFE p.C282Y+/+ (homozygous) genotype and central adiposity both increase liver disease and diabetes risks, but combined effects are unclear. We estimated…”
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A genome‐wide association study of the frailty index highlights brain pathways in ageing by Atkins, Janice L., Jylhävä, Juulia, Pedersen, Nancy L., Magnusson, Patrik K., Lu, Yi, Wang, Yunzhang, Hägg, Sara, Melzer, David, Williams, Dylan M., Pilling, Luke C.

“…Frailty is a common geriatric syndrome and strongly associated with disability, mortality and hospitalization. Frailty is commonly measured using the frailty…”
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Genetic associations for two biological age measures point to distinct aging phenotypes by Kuo, Chia‐Ling, Pilling, Luke C., Liu, Zuyun, Atkins, Janice L., Levine, Morgan E.

“…Biological age measures outperform chronological age in predicting various aging outcomes, yet little is known regarding genetic predisposition. We performed…”
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Central adiposity and the overweight risk paradox in aging: follow-up of 130,473 UK Biobank participants by Bowman, Kirsty, Atkins, Janice L, Delgado, João, Kos, Katarina, Kuchel, George A, Ble, Alessandro, Ferrucci, Luigi, Melzer, David

“…For older groups, being overweight [body mass index (BMI; in kg/m2): 25 to <30] is reportedly associated with a lower or similar risk of mortality than being…”
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ApoE e4e4 Genotype and Mortality With COVID-19 in UK Biobank by Kuo, Chia-Ling, Pilling, Luke C, Atkins, Janice L, Masoli, Jane A H, Delgado, João, Kuchel, George A, Melzer, David

“…The ApoE e4e4 genotype was associated with COVID-19 test positivity (odds ratio [OR] = 2.31,95% CI: 1.65-3.24, p = 1.19 · 10"6) (1) in the UK Biobank (UKB)…”
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