Search Results - "Athwal, Varinder S"

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis by Martin, Katherine, Pritchett, James, Llewellyn, Jessica, Mullan, Aoibheann F., Athwal, Varinder S., Dobie, Ross, Harvey, Emma, Zeef, Leo, Farrow, Stuart, Streuli, Charles, Henderson, Neil C., Friedman, Scott L., Hanley, Neil A., Piper Hanley, Karen

“…Fibrosis due to extracellular matrix (ECM) secretion from myofibroblasts complicates many chronic liver diseases causing scarring and organ failure…”
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The prevalence and burden of Rome IV bowel disorders of gut brain interaction in patients with non-alcoholic fatty liver disease: a cross-sectional study by Purssell, Huw, Bennett, Lucy, Street, Oliver, Hanley, Karen Piper, Hanley, Neil, Vasant, Dipesh H., Athwal, Varinder S.

“…Rome IV bowel disorders of gut brain interaction (DGBI) and non-alcoholic fatty liver disease (NAFLD) are highly prevalent entities with overlapping…”
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PAK1-dependent mechanotransduction enables myofibroblast nuclear adaptation and chromatin organization during fibrosis by Jokl, Elliot, Mullan, Aoibheann F., Simpson, Kara, Birchall, Lindsay, Pearmain, Laurence, Martin, Katherine, Pritchett, James, Raza, Sayyid, Shah, Rajesh, Hodson, Nigel W., Williams, Craig J., Camacho, Elizabeth, Zeef, Leo, Donaldson, Ian, Athwal, Varinder S., Hanley, Neil A., Piper Hanley, Karen

“…Myofibroblasts are responsible for scarring during fibrosis. The scar propagates mechanical signals inducing a radical transformation in myofibroblast cell…”
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SOX9 predicts progression toward cirrhosis in patients while its loss protects against liver fibrosis by Athwal, Varinder S, Pritchett, James, Llewellyn, Jessica, Martin, Katherine, Camacho, Elizabeth, Raza, Sayyid MA, Phythian‐Adams, Alexander, Birchall, Lindsay J, Mullan, Aoibheann F, Su, Kim, Pearmain, Laurence, Dolman, Grace, Zaitoun, Abed M, Friedman, Scott L, MacDonald, Andrew, Irving, William L, Guha, Indra N, Hanley, Neil A, Piper Hanley, Karen

“…Fibrosis and organ failure is a common endpoint for many chronic liver diseases. Much is known about the upstream inflammatory mechanisms provoking fibrosis…”
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Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells by Pritchett, James, Athwal, Varinder S, Harvey, Emma, Martin, Katherine, Llewellyn, Jessica, Ireland, Philip, Nicolaides, Alexander, Humphries, Martin J, Bobola, Nicoletta, Hanley, Neil A, Piper Hanley, Karen

“…Liver fibrosis is a major cause of morbidity and mortality. It is characterised by excessive extracellular matrix (ECM) deposition from activated hepatic…”
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Improving detection of cystic fibrosis related liver disease using liver fibrosis assessment tools by Scott, Jennifer A., Jones, Andrew M., Jokl, Elliot, Gordon-Walker, Timothy, Barry, Peter J., Hanley, Neil A., Piper Hanley, Karen, Athwal, Varinder S.

“…Cystic Fibrosis related liver disease (CFLD) is the 3rd largest cause of death in Cystic Fibrosis (CF). As advances in pulmonary therapies have increased…”
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Circadian Disruption Primes Myofibroblasts for Accelerated Activation as a Mechanism Underpinning Fibrotic Progression in Non-Alcoholic Fatty Liver Disease by Jokl, Elliot, Llewellyn, Jessica, Simpson, Kara, Adegboye, Oluwatobi, Pritchett, James, Zeef, Leo, Donaldson, Ian, Athwal, Varinder S, Purssell, Huw, Street, Oliver, Bennett, Lucy, Guha, Indra Neil, Hanley, Neil A, Meng, Qing-Jun, Piper Hanley, Karen

“…Circadian rhythm governs many aspects of liver physiology and its disruption exacerbates chronic disease. CLOCKΔ19 mice disrupted circadian rhythm and…”
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Review article: epidemiology, pathogenesis and management of liver disease in adults with cystic fibrosis by Scott, Jennifer, Jones, Andrew M., Piper Hanley, Karen, Athwal, Varinder S.

“…Summary Background Cystic fibrosis‐related liver disease (CFLD) is the leading cause of death in cystic fibrosis (CF), after pulmonary disease. To improve…”
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Emerging clinical perspectives in cystic fibrosis liver disease by Athwal, Varinder S., Scott, Jennifer A., Fitzpatrick, Emer, Rowland, Marion

“…Purpose of review Liver disease (CFLD) as a complication of cystic fibrosis is recognized as a more severe disease phenotype in both children and adults. We…”
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Genetic Contribution to Non-alcoholic Fatty Liver Disease and Prognostic Implications by Martin, Katherine, Hatab, Anas, Athwal, Varinder S., Jokl, Elliot, Piper Hanley, Karen

“…Purpose of Review Non-alcoholic fatty liver disease (NAFLD) is a major and increasing health burden, with the potential to overwhelm hepatology services…”
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COVID-19 and hepatorenal syndrome by Wu, Henry H L, Athwal, Varinder S, Kalra, Philip A, Chinnadurai, Rajkumar

“…Coronavirus disease 2019 (COVID-19) is a highly infectious disease which emerged into a global pandemic. Although it primarily causes respiratory symptoms for…”
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SOX9 is required for kidney fibrosis and activates NAV3 to drive renal myofibroblast function by Raza, Sayyid, Jokl, Elliot, Pritchett, James, Martin, Katherine, Su, Kim, Simpson, Kara, Birchall, Lindsay, Mullan, Aoibheann F, Athwal, Varinder S, Doherty, Daniel T, Zeef, Leo, Henderson, Neil C, Kalra, Philip A, Hanley, Neil A, Piper Hanley, Karen

“…Renal fibrosis is a common end point for kidney injury and many chronic kidney diseases. Fibrogenesis depends on the sustained activation of myofibroblasts,…”
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Non-alcoholic fatty liver disease in irritable bowel syndrome: More than a coincidence? by Purssell, Huw, Whorwell, Peter J, Athwal, Varinder S, Vasant, Dipesh H

“…Irritable bowel syndrome (IBS) and non-alcoholic fatty liver disease (NAFLD) are amongst the most common gastrointestinal and liver conditions encountered in…”
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SOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver fibrosis by Athwal, Varinder S., Pritchett, James, Martin, Katherine, Llewellyn, Jessica, Scott, Jennifer, Harvey, Emma, Zaitoun, Abed M., Mullan, Aoibheann F., Zeef, Leo A. H., Friedman, Scott L., Irving, William L., Hanley, Neil A., Guha, Indra N., Piper Hanley, Karen

“…Extracellular matrix (ECM) deposition and resultant scar play a major role in the pathogenesis and progression of liver fibrosis. Identifying core regulators…”
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Sa1606 Effect of Liver Progenitor Cells on Hepatic Stellate Cells by Chen, Iris, Athwal, Varinder S, Blas-Garcia, Ana, Lee, Youngmin A, Friedman, Scott L

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Publisher Correction: SOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver fibrosis by Athwal, Varinder S., Pritchett, James, Martin, Katherine, Llewellyn, Jessica, Scott, Jennifer, Harvey, Emma, Zaitoun, Abed M., Mullan, Aoibheann F., Zeef, Leo A. H., Friedman, Scott L., Irving, William L., Hanley, Neil A., Guha, Indra N., Piper Hanley, Karen

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Secondary sclerosing cholangitis following extracorporeal membrane oxygenation for acute respiratory distress in polytrauma by Tunney, Ruth, Scott, Jennifer, Rudralingam, Velauthan, Liong, Sue, Athwal, Varinder S.

“…Key Clinical Message Secondary sclerosing cholangitis is a recently identified phenomenon affecting the biliary tree. A subtype has been described in…”
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Emerging clinical perspectives in cystic fibrosis liver disease by Athwal, Varinder S., Scott, Jennifer A., Fitzpatrick, Emer, Rowland, Marion

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SOX 9 predicts progression toward cirrhosis in patients while its loss protects against liver fibrosis by Athwal, Varinder S, Pritchett, James, Llewellyn, Jessica, Martin, Katherine, Camacho, Elizabeth, Raza, Sayyid MA, Phythian‐Adams, Alexander, Birchall, Lindsay J, Mullan, Aoibheann F, Su, Kim, Pearmain, Laurence, Dolman, Grace, Zaitoun, Abed M, Friedman, Scott L, MacDonald, Andrew, Irving, William L, Guha, Indra N, Hanley, Neil A, Piper Hanley, Karen

“…Fibrosis and organ failure is a common endpoint for many chronic liver diseases. Much is known about the upstream inflammatory mechanisms provoking fibrosis…”
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Mechanism of SOX9 Action as a Route to Diagnostic Strategies in Liver Fibrosis by Athwal, Varinder S

“…The work presented in this thesis aims to understand the role of the Sry-box transcription factor (SOX9) in liver fibrosis as a route to novel diagnostic…”
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