Search Results - "Atherton, P. J."

Muscle protein synthesis in response to nutrition and exercise by Atherton, P. J., Smith, K.

“…Muscle protein synthesis (MPS) is the driving force behind adaptive responses to exercise and represents a widely adopted proxy for gauging chronic efficacy of…”
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An overview of technical considerations for Western blotting applications to physiological research by Bass, J. J., Wilkinson, D. J., Rankin, D., Phillips, B. E., Szewczyk, N. J., Smith, K., Atherton, P. J.

“…The applications of Western/immunoblotting (WB) techniques have reached multiple layers of the scientific community and are now considered routine procedures…”
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Architectural, functional and molecular responses to concentric and eccentric loading in human skeletal muscle by Franchi, M. V., Atherton, P. J., Reeves, N. D., Flück, M., Williams, J., Mitchell, W. K., Selby, A., Beltran Valls, R. M., Narici, M. V.

“…Aim We investigated architectural, functional and molecular responses of human skeletal muscle to concentric (CON) or eccentric (ECC) resistance training (RT)…”
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Caloric restriction improves glycaemic control without reducing plasma branched-chain amino acids or keto-acids in obese men by Sayda, M. H., Abdul Aziz, M. H., Gharahdaghi, N., Wilkinson, D. J., Greenhaff, P. L., Phillips, B. E., Smith, K., Idris, I., Atherton, P. J.

“…Higher plasma leucine, isoleucine and valine (BCAA) concentrations are associated with diabetes, obesity and insulin resistance (IR). Here, we evaluated the…”
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The metabolic effects of intermittent versus continuous feeding in critically ill patients by Wilkinson, D., Gallagher, I. J., McNelly, A., Bear, D. E., Hart, N., Montgomery, H. E., Le Guennec, A., Conte, M. R., Francis, T., Harridge, S. D. R., Atherton, P. J., Puthucheary, Z. A.

“…Intermittent (or bolus) feeding regimens in critically ill patients have been of increasing interest to clinicians and scientists. Changes in amino acid, fat…”
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Resistance exercise enhances mTOR and MAPK signalling in human muscle over that seen at rest after bolus protein ingestion by Moore, D.R, Atherton, P.J, Rennie, M.J, Tarnopolsky, M.A, Phillips, S.M

“…Aim: Feeding protein after resistance exercise enhances the magnitude and duration of myofibrillar protein synthesis (MPS) over that induced by feeding alone…”
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The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans by Wilkinson, D J, Piasecki, M, Atherton, P J

“…Age-related loss of skeletal muscle mass and function, sarcopenia, is associated with physical frailty and increased risk of morbidity (chronic diseases), in…”
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Skeletal muscle adaptations to physical inactivity and subsequent retraining in young men by Campbell, E. L., Seynnes, O. R., Bottinelli, R., McPhee, J. S., Atherton, P. J., Jones, D. A., Butler-Browne, G., Narici, M. V.

“…Skeletal muscle structure and function are markedly affected by chronic disuse. With unloading, muscle mass is lost at rate of about 0.4 %/day but little is…”
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Cyclic stretch reduces myofibrillar protein synthesis despite increases in FAK and anabolic signalling in L6 cells by Atherton, P. J., Szewczyk, N. J., Selby, A., Rankin, D., Hillier, K., Smith, K., Rennie, M. J., Loughna, P. T.

“…Muscle protein synthesis is increased after exercise, but evidence is now accruing that during muscular activity it is suppressed. In life, muscles are…”
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A phase III randomized, double-blind, placebo-controlled trial of gabapentin in the management of hot flashes in men (N00CB) by Loprinzi, C. L., Dueck, A. C., Khoyratty, B. S., Barton, D. L., Jafar, S., Rowland, K. M., Atherton, P. J., Marsa, G. W., Knutson, W. H., Bearden, J. D., Kottschade, L., Fitch, T. R.

“…Introduction: Hot flashes represent a significant problem in men undergoing androgen deprivation therapy. Materials and methods: Via a prospective,…”
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Management of hilar cholangiocarcinoma in the North of England: pathology, treatment, and outcome by Mansfield, S D, Barakat, O, Charnley, R M, Jaques, B C, O'Suilleabhain, C B, Atherton, P J, Manas, D

“…To assess the management and outcome of hilar cholangiocarcinoma (Klatskin tumor) in a single tertiary referral center. The notes of all patients with a…”
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Effects of leucine and its metabolite β‐hydroxy‐β‐methylbutyrate on human skeletal muscle protein metabolism by Wilkinson, D. J., Hossain, T., Hill, D. S., Phillips, B. E., Crossland, H., Williams, J., Loughna, P., Churchward‐Venne, T. A., Breen, L., Phillips, S. M., Etheridge, T., Rathmacher, J. A., Smith, K., Szewczyk, N. J., Atherton, P. J.

“…Key points •  The branched‐chain amino acid (BCAA) leucine acts as both a ‘trigger’ for the initiation of protein synthesis, and as a substrate for newly…”
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Effects of leucine and its metabolite [beta]-hydroxy-[beta]-methylbutyrate on human skeletal muscle protein metabolism by Wilkinson, D J, Hossain, T, Hill, D S, Phillips, B E, Crossland, H, Williams, J, Loughna, P, Churchward-Venne, T A, Breen, L, Phillips, S M, Etheridge, T, Rathmacher, J A, Smith, K, Szewczyk, N J, Atherton, P J

“…Key points * The branched-chain amino acid (BCAA) leucine acts as both a 'trigger' for the initiation of protein synthesis, and as a substrate for newly…”
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Age-related changes in muscle architecture and metabolism in humans: The likely contribution of physical inactivity to age-related functional decline by Shur, N.F., Creedon, L., Skirrow, S., Atherton, P.J., MacDonald, I.A., Lund, J., Greenhaff, P.L.

“…•Ageing is associated with declines in muscle mass, quality and insulin sensitivity.•These features of ageing quickly manifest in young exposed to physical…”
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Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise by Brook, M. S., Wilkinson, D. J., Phillips, B. E., Perez-Schindler, J., Philp, A., Smith, K., Atherton, P. J.

“…Skeletal muscles comprise a substantial portion of whole body mass and are integral for locomotion and metabolic health. Increasing age is associated with…”
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A phase II study of the bispecific antibody MDX-H210 (anti-HER2 × CD64) with GM-CSF in HER2+ advanced prostate cancer by JAMES, N. D, ATHERTON, P. J, JONES, J, HOWIE, A. J, TCHEKMEDYIAN, S, CURNOW, R. T

“…The proto-oncogene HER2 presents a novel therapeutic target. We report results in 25 patients with HER2+ advanced prostate cancer treated with the bispecific…”
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Regional regulation of focal adhesion kinase after concentric and eccentric loading is related to remodelling of human skeletal muscle by Franchi, M. V., Ruoss, S., Valdivieso, P., Mitchell, K. W., Smith, K., Atherton, P. J., Narici, M. V., Flück, M.

“…Aims We assessed focal adhesion kinase (FAK) response to concentric (CON) vs eccentric (ECC) resistance training (RT) at two vastus lateralis (VL) sites, and…”
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Food texture: A potential dietary consideration for obesity prevention? by Etheridge, T., Atherton, P. J.

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Protein dose requirements to maximize skeletal muscle protein synthesis after repeated bouts of resistance exercise in young trained women by Mallinson, J. E., Wardle, S. L., O'Leary, T. J., Greeves, J. P., Cegielski, J., Bass, J., Brook, M. S., Wilkinson, D. J., Smith, K., Atherton, P. J., Greenhaff, P. L.

“…Abstract Studies examining the effect of protein (PRO) feeding on post resistance exercise (RE) muscle protein synthesis (MPS) have primarily been performed in…”
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Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism by Wilkinson, D.J., Hossain, T., Limb, M.C., Phillips, B.E., Lund, J., Williams, J.P., Brook, M.S., Cegielski, J., Philp, A., Ashcroft, S., Rathmacher, J.A., Szewczyk, N.J., Smith, K., Atherton, P.J.

“…β-hydroxy-β-methylbutyrate (HMB) is purported as a key nutritional supplement for the preservation of muscle mass in health, disease and as an ergogenic aid in…”
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