Search Results - "Atherton, Joseph"

Tubulin isoform composition tunes microtubule dynamics by Vemu, Annapurna, Atherton, Joseph, Spector, Jeffrey O, Moores, Carolyn A, Roll-Mecak, Antonina

“…Microtubules polymerize and depolymerize stochastically, a behavior essential for cell division, motility, and differentiation. While many studies advanced our…”
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Structure and Dynamics of Single-isoform Recombinant Neuronal Human Tubulin by Vemu, Annapurna, Atherton, Joseph, Spector, Jeffrey O., Szyk, Agnieszka, Moores, Carolyn A., Roll-Mecak, Antonina

“…Microtubules are polymers that cycle stochastically between polymerization and depolymerization, i.e. they exhibit “dynamic instability.” This behavior is…”
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MAPping out distribution routes for kinesin couriers by Atherton, Joseph, Houdusse, Anne, Moores, Carolyn

“…In the crowded environment of eukaryotic cells, diffusion is an inefficient distribution mechanism for cellular components. Long‐distance active transport is…”
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Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression by Adib, Rozita, Montgomery, Jessica M, Atherton, Joseph, O'Regan, Laura, Richards, Mark W, Straatman, Kees R, Roth, Daniel, Straube, Anne, Bayliss, Richard, Moores, Carolyn A, Fry, Andrew M

“…EML4 is a microtubule-associated protein that promotes microtubule stability. We investigated its regulation across the cell cycle and found that EML4 was…”
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Structural determinants of microtubule minus end preference in CAMSAP CKK domains by Atherton, Joseph, Luo, Yanzhang, Xiang, Shengqi, Yang, Chao, Rai, Ankit, Jiang, Kai, Stangier, Marcel, Vemu, Annapurna, Cook, Alexander D., Wang, Su, Roll-Mecak, Antonina, Steinmetz, Michel O., Akhmanova, Anna, Baldus, Marc, Moores, Carolyn A.

“…CAMSAP/Patronins regulate microtubule minus-end dynamics. Their end specificity is mediated by their CKK domains, which we proposed recognise specific tubulin…”
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Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins by Atherton, Joseph, Farabella, Irene, Yu, I-Mei, Rosenfeld, Steven S, Houdusse, Anne, Topf, Maya, Moores, Carolyn A

“…Kinesins are a superfamily of microtubule-based ATP-powered motors, important for multiple, essential cellular functions. How microtubule binding stimulates…”
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The mechanism of kinesin inhibition by kinesin-binding protein by Atherton, Joseph, Hummel, Jessica Ja, Olieric, Natacha, Locke, Julia, Peña, Alejandro, Rosenfeld, Steven S, Steinmetz, Michel O, Hoogenraad, Casper C, Moores, Carolyn A

“…Subcellular compartmentalisation is necessary for eukaryotic cell function. Spatial and temporal regulation of kinesin activity is essential for building these…”
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Structure Determination of Microtubules and Pili: Past, Present, and Future Directions by Garnett, James A, Atherton, Joseph

“…Historically proteins that form highly polymeric and filamentous assemblies have been notoriously difficult to study using high resolution structural…”
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The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry by Atherton, Joseph, Yu, I-Mei, Cook, Alexander, Muretta, Joseph M, Joseph, Agnel, Major, Jennifer, Sourigues, Yannick, Clause, Jeffrey, Topf, Maya, Rosenfeld, Steven S, Houdusse, Anne, Moores, Carolyn A

“…MKLP2, a kinesin-6, has critical roles during the metaphase-anaphase transition and cytokinesis. Its motor domain contains conserved nucleotide binding motifs,…”
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A leaf-mounted thermal sensor for the measurement of water content by Atherton, Joseph J., Rosamond, Mark C., Zeze, Dagou A.

“…► We present a micro-thermal sensor for the real-time detection of the water content of plant leaves. ► Temperature differences (ΔT) induced within leaf can be…”
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Abstract OR-8: High-Resolution Structures of Microtubule-Drug Complexes Revealed by Cryo-EM by Sejwal, Kushal, Blum, Thorsten, Atherton, Joseph, Sharma, Ashwani, Olieric, Natacha, Prota, Andrea, Moores, Carolyn, Steinmetz, Michel

“…Background: Microtubules are dynamic protein filaments that are crucial for cell division and constitute key elements of the cytoskeleton. They are assembled…”
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Microtubule architecture in vitro and in cells revealed by cryo‐electron tomography by Atherton, Joseph, Stouffer, Melissa, Francis, Fiona, Moores, Carolyn A.

“…The microtubule cytoskeleton is involved in many vital cellular processes. Microtubules act as tracks for molecular motors, and their polymerization and…”
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Visualising the cytoskeletal machinery in neuronal growth cones using cryo-electron tomography by Atherton, Joseph, Stouffer, Melissa, Francis, Fiona, Moores, Carolyn A

“…Neurons extend axons to form the complex circuitry of the mature brain. This depends on the coordinated response and continuous remodelling of the microtubule…”
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Cryo‐EM of kinesin‐binding protein: challenges and opportunities from protein‐surface interactions by Atherton, Joseph, Moores, Carolyn A.

“…Kinesin‐binding protein (KBP) is an important selective inhibitor of specific kinesin family members and its genetic disruption causes Goldberg–Shprintzen…”
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Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition by Cook, Alexander D., Roberts, Anthony J., Atherton, Joseph, Tewari, Rita, Topf, Maya, Moores, Carolyn A.

“…Plasmodium parasites cause malaria and are responsible annually for hundreds of thousands of deaths. Kinesins are a superfamily of microtubule-dependent…”
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A microtubule RELION-based pipeline for cryo-EM image processing by Cook, Alexander D., Manka, Szymon W., Wang, Su, Moores, Carolyn A., Atherton, Joseph

“…[Display omitted] •MiRP is a pipeline for processing cryo-EM images of microtubules in RELION.•MiRP manages microtubule heterogeneity and pseudo-symmetry.•MiRP…”
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The Mechanism of Selective Kinesin Inhibition by Kinesin Binding Protein by Atherton, Joseph, Hummel, Jessica J., Olieric, Natacha, Steinmetz, Michel O., Akhmanova, Anna, Hoogenraad, Casper, Moores, Carolyn A.

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A structural model for microtubule minus-end recognition and protection by CAMSAP proteins by Atherton, Joseph, Jiang, Kai, Stangier, Marcel M, Luo, Yanzhang, Hua, Shasha, Houben, Klaartje, van Hooff, Jolien J E, Joseph, Agnel-Praveen, Scarabelli, Guido, Grant, Barry J, Roberts, Anthony J, Topf, Maya, Steinmetz, Michel O, Baldus, Marc, Moores, Carolyn A, Akhmanova, Anna

“…Combined structural and microscopy approaches provide a model for how CAMSAP proteins recognize microtubule minus ends through their conserved CCK domains and…”
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Mapping the Processivity Determinants of the Kinesin-3 Motor Domain by Scarabelli, Guido, Soppina, Virupakshi, Yao, Xin-Qiu, Atherton, Joseph, Moores, Carolyn A., Verhey, Kristen J., Grant, Barry J.

“…Kinesin superfamily members play important roles in many diverse cellular processes, including cell motility, cell division, intracellular transport, and…”
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A Structural Model of the Mitotic Kinesin-6 Mechanochemical Cycle by Atherton, Joseph, Yu, I-Mei, Rosenfeld, Steven S., Houdusse, Anne, Moores, Carolyn A.

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