Search Results - "Athersuch, T."

A metabolic phenotyping approach to understanding relationships between metabolic syndrome and breast tumour responses to chemotherapy by Stebbing, J., Sharma, A., North, B., Athersuch, T.J., Zebrowski, A., Pchejetski, D., Coombes, R.C., Nicholson, J.K., Keun, H.C.

“…Breast cancer is associated with adverse outcomes in patients with the metabolic syndrome phenotype. To study this further, we examined the relationship…”
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Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice by Viant, Mark R., Amstalden, E., Athersuch, T., Bouhifd, M., Camuzeaux, S., Crizer, D. M., Driemert, P., Ebbels, T., Ekman, D., Flick, B., Giri, V., Gómez-Romero, M., Haake, V., Herold, M., Kende, A., Lai, F., Leonards, P. E. G., Lim, P. P., Lloyd, G. R., Mosley, J., Namini, C., Rice, J. R., Romano, S., Sands, C., Smith, M. J., Sobanski, T., Southam, A. D., Swindale, L., van Ravenzwaay, B., Walk, T., Weber, R. J. M., Zickgraf, F. M., Kamp, H.

“…While grouping/read-across is widely used to fill data gaps, chemical registration dossiers are often rejected due to weak category justifications based on…”
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Evaluation of the use of UPLC-TOFMS with simultaneous [ 14C]-radioflow detection for drug metabolite profiling: Application to propranolol metabolites in rat urine by Athersuch, T.J., Sison, R.L., Kenyon, A.S.J., Clarkson-Jones, J.A., Wilson, I.D.

“…The non-selective β-adrenergic receptor antagonist propranolol [1-(isopropylamino)-3-(1-naphthoxy)-2-propanol] is metabolised extensively in vivo. Enumerating…”
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UPLC-MS, HPLC-radiometric, and NMR-spectroscopic studies on the metabolic fate of 3-fluoro-[U-14C]-aniline in the bile-cannulated rat by Athersuch, T. J., Castro-Perez, J., Rodgers, C., Nicholson, J. K., Wilson, I. D.

“…A study of the rates and routes of excretion of 3-fluoro-[U-14C]aniline following intraperitoneal administration to male bile-cannulated rats by liquid…”
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Quantitative urinalysis of the mercapturic acid conjugates of allyl formate using high-resolution NMR spectroscopy by Athersuch, T.J., Keun, H., Tang, H., Nicholson, J.K.

“…As end products of xenobiotic metabolism via glutathione conjugation, mercapturic acids (MCAs) can be used as markers to indicate exposure to allylic compounds…”
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Metabolism of [14C]-5-chloro-1,3-benzodioxol-4-amine in male Wistar-derived rats following intraperitoneal administration by Athersuch, T. J., Duckett, C. J., Castro-Perez, J., Rodgers, C., Nicholson, J. K., Wilson, I. D.

“…[14C]-5-chloro-1,3-benzodioxol-4-amine was administered intraperitoneally (i.p.) to bile duct-cannulated rats (Alpk:ApfSD, Wistar derived) at 25 mg kg−1 to…”
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P24-26: Metabolomics-based chemical grouping – a robust and reproducible tool enabling read-across by Kamp, H., Amstalden, E., Athersuch, T., Bouhifd, M., Ebbels, T., Ekman, D., Haake, V., Kende, A., Leonards, P., Lloyd, G., Mosley, J., Sands, C., Sobanski, T., Walk, T., Weber, R., Zickgraf, F., Viant, M.

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Prediagnostic transcriptomic markers of Chronic lymphocytic leukemia reveal perturbations 10 years before diagnosis by Chadeau-Hyam, M., Vermeulen, R.C.H., Hebels, D.G.A.J., Castagné, R., Campanella, G., Portengen, L., Kelly, R.S., Bergdahl, I.A., Melin, B., Hallmans, G., Palli, D., Krogh, V., Tumino, R., Sacerdote, C., Panico, S., de Kok, T.M.C.M., Smith, M.T., Kleinjans, J.C.S., Vineis, P., Kyrtopoulos, S.A., Georgiadis, P., Botsivali, M., Papadopoulou, C., Chatziioannou, A., Valavanis, I., Gottschalk, R., van Leeuwen, D., Timmermans, L., Keun, H.C., Athersuch, T.J., Lenner, P., Bendinelli, B., Stephanou, E.G., Myridakis, A., Kogevinas, M., Saberi-Hosnijeh, F., Fazzo, L., de Santis, M., Comba, P., Kiviranta, H., Rantakokko, P., Airaksinen, R., Ruokojarvi, P., Gilthorpe, M.S., Fleming, S., Fleming, T., Tu, Y.-K., Jonsson, B., Lundh, T., Chien, K.-L., Chen, W.J., Lee, W.-C., Hsiao, C.K., Kuo, P.-H., Hung, H., Liao, S.-F.

“…B-cell lymphomas are a diverse group of hematological neoplasms with differential etiology and clinical trajectories. Increased insights in the etiology and…”
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A metabolic phenotyping approach to understanding relationships between metabolic syndrome and breast tumor responses to chemotherapy by Stebbing, J., Sharma, A., North, B., Athersuch, T. J., Zebrowski, A., Pchejetski, D., Coombes, R. C., Nicholson, J. K., Keun, H. C.

“…Abstract only…”
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The carcinoGENOMICS project: Critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays by Vinken, Mathieu, Doktorova, Tatyana, Ellinger-Ziegelbauer, Heidrun, Ahr, Hans-Jürgen, Lock, Edward, Carmichael, Paul, Roggen, Erwin, van Delft, Joost, Kleinjans, Jos, Castell, José, Bort, Roque, Donato, Teresa, Ryan, Michael, Corvi, Raffaella, Keun, Hector, Ebbels, Timothy, Athersuch, Toby, Sansone, Susanna-Assunta, Rocca-Serra, Philippe, Stierum, Rob, Jennings, Paul, Pfaller, Walter, Gmuender, Hans, Vanhaecke, Tamara, Rogiers, Vera

“…Recent changes in the European legislation of chemical-related substances have forced the scientific community to speed up the search for alternative methods…”
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Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective by Athersuch, Toby J, Antoine, Daniel J, Boobis, Alan R, Coen, Muireann, Daly, Ann K, Possamai, Lucia, Nicholson, Jeremy K, Wilson, Ian D

“…After over 60 years of therapeutic use in the UK, paracetamol (acetaminophen, -acetyl- -aminophenol, APAP) remains the subject of considerable research into…”
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Two electron reduction of 2,3-dimethoxy-1,4-naphthoquinone metabolism in vivo prevents redox stress but interaction with the electron transport chain may be a mechanism of toxicity by Gant, Timothy, Lutz, Ursula, Parry, Joel, Pointon, Amy, Charlwood, Joanne, Teichert, Friederike, Athersuch, Toby, Taylor, Emma, Keun, Hector, Lyon, Jonathan, Lutz, Werner

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Metabolic profiling detects early effects of environmental and lifestyle exposure to cadmium in a human population by Ellis, James K, Athersuch, Toby J, Thomas, Laura D K, Teichert, Friederike, Pérez-Trujillo, Miriam, Svendsen, Claus, Spurgeon, David J, Singh, Rajinder, Järup, Lars, Bundy, Jacob G, Keun, Hector C

“…The 'exposome' represents the accumulation of all environmental exposures across a lifetime. Top-down strategies are required to assess something this…”
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