To be remembered: B cell memory response against SARS‐CoV‐2 and its variants in vaccinated and unvaccinated individuals

To be remembered: B cell memory response against SARS‐CoV‐2 and its variants in vaccinated and unvaccinated individuals

COVID‐19 disease has plagued the world economy and affected the overall well‐being and life of most of the people. Natural infection as well as vaccination leads to the development of an immune response against the pathogen. This involves the production of antibodies, which can neutralize the virus...

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Bibliographic Details
Published in:Scandinavian journal of immunology Vol. 99; no. 2; pp. e13345 - n/a
Main Authors: Ahmed, Nafees, Athavale, Atharv, Tripathi, Ankita H., Subramaniam, Adarsh, Upadhyay, Santosh K., Pandey, Anil Kumar, Rai, Ramesh Chandra, Awasthi, Amit
Format: Journal Article
Language:English
Published: England Wiley Subscription Services, Inc 01-02-2024
Subjects:
COVID-19
Global economy
hybrid immunity
immune response
Immunological memory
Lymphocytes T
memory B cell
Memory cells
SARS‐CoV‐2
Severe acute respiratory syndrome coronavirus 2
vaccine
vaccine
SARS‐CoV‐2
immune response
hybrid immunity
memory B cell
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Summary:COVID‐19 disease has plagued the world economy and affected the overall well‐being and life of most of the people. Natural infection as well as vaccination leads to the development of an immune response against the pathogen. This involves the production of antibodies, which can neutralize the virus during future challenges. In addition, the development of cellular immune memory with memory B and T cells provides long‐lasting protection. The longevity of the immune response has been a subject of intensive research in this field. The extent of immunity conferred by different forms of vaccination or natural infections remained debatable for long. Hence, understanding the effectiveness of these responses among different groups of people can assist government organizations in making informed policy decisions. In this article, based on the publicly available data, we have reviewed the memory response generated by some of the vaccines against SARS‐CoV‐2 and its variants, particularly B cell memory in different groups of individuals. Schematic diagram of different vaccine platforms utilized against SARS‐CoV‐2 and the immunological consequences of vaccination.
Bibliography:Atharv Athavale and Ankita H. Tripathi have contributed equally.
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0300-9475
1365-3083
DOI:10.1111/sji.13345