Search Results - "Athanassiou, Zafiria"

Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein by Davidson, Amy, Leeper, Thomas C, Athanassiou, Zafiria, Patora-Komisarska, Krystyna, Karn, Jonathan, Robinson, John A, Varani, Gabriele

“…The interaction of the HIV-1 transactivator protein Tat with its transactivation response (TAR) RNA is an essential step in viral replication and therefore an…”
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Inhibition of both HIV-1 reverse transcription and gene expression by a cyclic peptide that binds the Tat-transactivating response element (TAR) RNA by Lalonde, Matthew S, Lobritz, Michael A, Ratcliff, Annette, Chamanian, Mastooreh, Athanassiou, Zafiria, Tyagi, Mudit, Wong, Julian, Robinson, John A, Karn, Jonathan, Varani, Gabriele, Arts, Eric J

“…The RNA response element TAR plays a critical role in HIV replication by providing a binding site for the recruitment of the viral transactivator protein Tat…”
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Design of β-Hairpin Peptidomimetics That Inhibit Binding of α-Helical HIV-1 Rev Protein to the Rev Response Element RNA by Moehle, Kerstin, Athanassiou, Zafiria, Patora, Krystyna, Davidson, Amy, Varani, Gabriele, Robinson, John A.

“…Bound to please: Binding of the Rev protein to HIV‐1 RRE RNA is essential for virus replication. A strategy for the discovery of Rev‐RRE inhibitors, based on…”
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Structure-Guided Peptidomimetic Design Leads to Nanomolar β-Hairpin Inhibitors of the Tat−TAR Interaction of Bovine Immunodeficiency Virus by Athanassiou, Zafiria, Patora, Krystyna, Dias, Ricardo L. A, Moehle, Kerstin, Robinson, John A, Varani, Gabriele

“…The Tat protein of immunodeficiency viruses is the main activator of viral gene expression. By binding specifically to its cognate site, the transactivator…”
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Structural Mimicry of Retroviral Tat Proteins by Constrained β-Hairpin Peptidomimetics:  Ligands with High Affinity and Selectivity for Viral TAR RNA Regulatory Elements by Athanassiou, Zafiria, Dias, Ricardo L. A, Moehle, Kerstin, Dobson, Neil, Varani, Gabriele, Robinson, John A

“…An approach is described to the design of β-hairpin peptidomimetic ligands for bovine immunodeficiency virus (BIV) Tat protein, which inhibit binding to its…”
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TAR RNA Recognition by a Cyclic Peptidomimetic of Tat Protein by Leeper, Thomas C, Athanassiou, Zafiria, Dias, Ricardo L. A, Robinson, John A, Varani, Gabriele

“…The search for new antiviral drugs that repress HIV viral replication by blocking transactivation of viral RNA transcription has long been advocated as an…”
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Macrocyclic Hairpin Mimetics of the Cationic Antimicrobial Peptide Protegrin I: A New Family of Broad-Spectrum Antibiotics by Shankaramma, Sasalu C., Athanassiou, Zafiria, Zerbe, Oliver, Moehle, Kerstin, Mouton, Carole, Bernardini, Francesca, Vrijbloed, Jan W., Obrecht, Daniel, Robinson, John A.

“…The problems associated with increasing antibiotic resistance have stimulated great interest in newly discovered families of naturally occurring cationic…”
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Design von β‐Haarnadel‐Peptidmimetika zur Hemmung der Bindung des α‐helicalen HIV‐1‐Rev‐Proteins an das Rev‐RNA‐Erkennungselement by Moehle, Kerstin, Athanassiou, Zafiria, Patora, Krystyna, Davidson, Amy, Varani, Gabriele, Robinson, John A.

“…Die Bindung des Rev‐Proteins an das Rev‐Erkennungselement des humanen Immundefizienzvirus Typ 1 (HIV‐1) ist entscheidend für die Virusreplikation. Eine neue…”
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Thermodynamic origin ofcis/trans isomers of a proline-containing β-turn model dipeptide in aqueous solution: A combined variable temperature1H-NMR, two-dimensional1H,1H gradient enhanced nuclear overhauser effect spectroscopy (NOESY), one-dimensional steady-state intermolecular13C,1H NOE, and molecular dynamics study by Troganis, Anastasios, Gerothanassis, Ioannis P., Athanassiou, Zafiria, Mavromoustakos, Thomas, Hawkes, Geoffrey E., Sakarellos, Constantinos

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Thermodynamic origin of cis/trans isomers of a proline-containing beta -turn model dipeptide in aqueous solution: A combined variable temperature super(1)H-nmr, two-dimensional super(1)H, super(1)H gradient enhanced nuclear Overhauser effect spectroscopy (NOESY), one-dimensional steady-state intermolecular super(13)C, super(1)H NOE, and molecular dynamics study by Troganis, Anastasios, Gerothanassis, Ioannis P, Athanassiou, Zafiria, Mavromoustakos, Thomas, Hawkes, Geoffrey E, Sakarellos, Constantinos

“…The cis/trans conformational equilibrium of the two Ac-Pro somers of the beta -turn model dipeptide [13C]-Ac-L-Pro-D-Ala-NHMe, 98% super(13)C enriched at the…”
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Thermodynamic origin of cis/trans isomers of a proline-containing β-turn model dipeptide in aqueous solution: A combined variable temperature 1H-NMR, two-dimensional 1H,1H gradient enhanced nuclear overhauser effect spectroscopy (NOESY), one-dimensional steady-state intermolecular 13C,1H NOE, and molecular dynamics study by Troganis, Anastasios, Gerothanassis, Ioannis P., Athanassiou, Zafiria, Mavromoustakos, Thomas, Hawkes, Geoffrey E., Sakarellos, Constantinos

“…The cis/trans conformational equilibrium of the two Ac–Pro isomers of the β‐turn model dipeptide [13C]–Ac–L‐Pro–D‐Ala–NHMe, 98% 13C enriched at the acetyl…”
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Design von β-Haarnadel-Peptidmimetika zur Hemmung der Bindung des α-helicalen HIV-1-Rev-Proteins an das Rev-RNA-Erkennungselement by Moehle, Kerstin, Athanassiou, Zafiria, Patora, Krystyna, Davidson, Amy, Varani, Gabriele, Robinson, John A.

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