Search Results - "Athanasou, N"

The pathobiology and pathology of aseptic implant failure by Athanasou, N A

“…Pathological assessment of periprosthetic tissues is important, not only for diagnosis, but also for understanding the pathobiology of implant failure. The…”
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Fracture-related infection: A consensus on definition from an international expert group by Metsemakers, WJ, Morgenstern, M., McNally, M.A., Moriarty, T.F., McFadyen, I., Scarborough, M., Athanasou, N.A., Ochsner, P.E., Kuehl, R., Raschke, M., Borens, O., Xie, Z., Velkes, S., Hungerer, S., Kates, S.L., Zalavras, C., Giannoudis, P.V., Richards, R.G., Verhofstad, M.H.J.

“…Fracture-related infection (FRI) is a common and serious complication in trauma surgery. Accurately estimating the impact of this complication has been…”
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Non-Canonical (RANKL-Independent) Pathways of Osteoclast Differentiation and Their Role in Musculoskeletal Diseases by Sabokbar, A., Mahoney, D. J., Hemingway, F., Athanasou, N. A.

“…Osteoclasts are multinucleated cells derived from mononuclear phagocyte precursors (monocytes, macrophages); in the canonical pathway of osteoclastogenesis,…”
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Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis by Zhang, T, Kastrenopoulou, A, Larrouture, Q, Athanasou, N A, Knowles, H J

“…Osteosarcoma is the most common primary bone cancer in children and young adults. It is highly aggressive and patients that present with metastasis have a poor…”
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RANKL-independent human osteoclast formation with APRIL, BAFF, NGF, IGF I and IGF II by Hemingway, F, Taylor, R, Knowles, H.J, Athanasou, N.A

“…Abstract Non-canonical pathways of osteoclastogenesis have been described in which several cytokines are able to substitute for RANKL. These cytokines are few…”
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Histopathology in Periprosthetic Joint Infection: When Will the Morphomolecular Diagnosis Be a Reality? by Bori, G., Athanasou, N., McNally, M. A.

“…The presence of a polymorphonuclear neutrophil infiltrate in periprosthetic tissues has been shown to correlate closely with the diagnosis of septic implant…”
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The role of histology in the diagnosis of spondylodiscitis: correlation with clinical and microbiological findings by Iwata, E, Scarborough, M, Bowden, G, McNally, M, Tanaka, Y, Athanasou, N A

“…AimsThe aim of this study was to determine the diagnostic utility of histological analysis in spinal biopsies for spondylodiscitis (SD).Patients and…”
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Intraosseous hibernoma: a rare adipocytic bone tumour by Vlychou, M., Teh, J., Whitwell, D., Athanasou, N. A.

“…Hibernoma is a benign adipose tumour that contains foetal brown fat cells. We report a case of hibernoma arising in the left ischium of a 65-year-old female…”
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Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up by Hogendoorn, P. C. W., Athanasou, N., Bielack, S., De Alava, E., Tos, A. P. Dei, Ferrari, S., Gelderblom, H., Grimer, R., Hall, K. Sundby, Hassan, B., Hogendoorn, P. C. W., Jurgens, H., Paulussen, M., Rozeman, L., Taminiau, A.H.M., Whelan, J., Vanel, D.

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Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF by Knowles, HJ, Athanasou, NA

“…Hypoxia is an important regulator of bone biology and stimulates osteoclast differentiation from monocytic precursors. Hypoxia-inducible factor (HIF) is a key…”
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Development of malignant lymphoma after metal-on-metal hip replacement: a case report and review of the literature by McCarthy, C. L., Uchihara, Y., Vlychou, M., Grammatopoulos, G., Athanasou, N. A.

“…A number of previous studies have reported a potential risk of malignancy, particularly hematological malignancy, developing in patients receiving a…”
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Management and outcome of acral soft-tissue sarcomas by Dean, B J F, Branford-White, H, Giele, H, Critchley, P, Cogswell, L, Athanasou, N, Gibbons, C L M

“…The aim of this study was to evaluate the surgical management and outcome of patients with an acral soft-tissue sarcoma of the hand or foot. We identified 63…”
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Necrotic granulomatous pseudotumours in bilateral resurfacing hip arthoplasties: evidence for a type IV immune response by Pandit, H., Vlychou, M., Whitwell, D., Crook, D., Luqmani, R., Ostlere, S., Murray, D. W., Athanasou, N. A.

“…Clinical, radiological and histological findings were analysed in four patients who developed bilateral pseudotumours following metal-on-metal (MoM)…”
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The microbiology of chronic osteomyelitis: Prevalence of resistance to common empirical anti-microbial regimens by Sheehy, S.H, Atkins, B.A, Bejon, P, Byren, I, Wyllie, D, Athanasou, N.A, Berendt, A.R, McNally, M.A

“…Summary Objectives This study describes the microbiological spectrum of chronic osteomyelitis and so guides the choice of empirical antibiotics for this…”
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Chondroclasts are mature osteoclasts which are capable of cartilage matrix resorption by Knowles, H. J., Moskovsky, L., Thompson, M. S., Grunhen, J., Cheng, X., Kashima, T. G., Athanasou, N. A.

“…Multinucleated cells termed chondroclasts have been observed on the deep surface of resorbed hyaline cartilage but the relationship of these cells to…”
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The management and outcome of large volume liposarcomas encasing the sciatic nerve by Williams, M.A., Athanasou, N., Gibbons, C.L.M.H., Cosker, T.D.A.

“…This paper outlines the oncological outcomes of patients with large volume liposarcomas of the posterior thigh who underwent nerve-preserving surgery utilising…”
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Primary synovial chondromatosis: a reassessment of malignant potential in 155 cases by McCarthy, C., Anderson, W. J., Vlychou, M., Inagaki, Y., Whitwell, D., Gibbons, C. L. M. H., Athanasou, N. A.

“…Objective Primary synovial chondromatosis (PSC) is a rare disorder characterised by cartilage formation in synovium-lined joints, tendon sheaths and bursae. It…”
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Comparison of outcomes after UKA in patients with and without chondrocalcinosis: a matched cohort study by Kumar, V., Pandit, H. G., Liddle, A. D., Borror, W., Jenkins, C., Mellon, S. J., Hamilton, T. W., Athanasou, N., Dodd, C. A. F., Murray, D. W.

“…Purpose Chondrocalcinosis can be associated with an inflammatory arthritis and aggressive joint destruction. There is uncertainty as to whether…”
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Use of chloroacetate esterase staining for the histological diagnosis of prosthetic joint infection by Kashima, T. G., Inagaki, Y., Grammatopoulos, G., Athanasou, N. A.

“…A heavy neutrophil polymorph infiltrate [>5 per high-power field (HPF) after examination of at least 5 HPF by Musculoskeletal Infection Society (MSIS)…”
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Solochrome cyanine: A histological stain for cobalt-chromium wear particles in metal-on-metal periprosthetic tissues by Papadimitriou-Olivgeri, I., Brown, J. M., Kilpatrick, A. F. R., Gill, H. S., Athanasou, N. A.

“…Metal-on-metal (MoM) hip arthroplasties produce abundant implant-derived wear debris composed mainly of cobalt (Co) and chromium (Cr). Cobalt-chromium (Co-Cr)…”
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