Search Results - "Athanacio, Jon"

Discovery of 4-(3-aminopyrrolidinyl)-3-aryl-5-(benzimidazol-2-yl)-pyridines as potent and selective SST5 agonists for the treatment of congenital hyperinsulinism by Zhao, Jian, Wang, Shimiao, Hee Kim, Sun, Han, Sangdon, Rico-Bautista, Elizabeth, Sturchler, Emmanuel, Nguyen, Julie, Tan, Hannah, Staley, Christine, Karin Kusnetzow, Ana, Betz, Stephen F., Johns, Michael, Goulet, Lance, Luo, Rosa, Fowler, Melissa, Athanacio, Jon, Markison, Stacy, Scott Struthers, R., Zhu, Yunfei

“…[Display omitted] SST5 receptor activation potently inhibits insulin secretion from pancreatic β-cells, and an orally available nonpeptide selective SST5…”
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Effects of CRN04894, a Nonpeptide Orally Bioavailable ACTH Antagonist, on Corticosterone in Rodent Models of ACTH Excess by Fowler, Melissa A, Kusnetzow, Ana Karin, Han, Sangdon, Reinhart, Greg, Kim, Sun Hee, Johns, Michael, Kredel, Taylor A, Antwan, Agnes, Athanacio, Jon, Tsivkovski, Oleg, Luo, Rosa, Madan, Ajay, Zhu, Yun Fei, Betz, Stephen F, Struthers, Scott, Markison, Stacy

“…CRN04894 is an orally administered nonpeptide that is a potent and selective antagonist for adrenocorticotropic hormone (ACTH) acting at the melanocortin 2…”
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SAT-260 Selective Nonpeptide Somatostatin Subtype 5 (sst5) Agonists Suppress Induced Insulin Secretion in Pancreatic Islets from both Rats and Healthy Human Donors by Rico-Bautista, Elizabeth, Kusnetzow, Ana, Fowler, Melissa, Athanacio, Jon, Kredel, Taylor, Zhao, Jian, Wang, Shimiao, Markison, Stacy, Zhu, Yun Fei, Struthers, Scott, Betz, Stephen

“…Hyperinsulinemia is a heterogeneous condition in which dangerously low blood sugar levels are caused by improperly regulated insulin secretion from pancreatic…”
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OR19-03 Effects of Nonpeptide Orally Bioavailable ACTH Antagonists on Adrenal Gland Size and Function in Rats by Markison, Stacy, Fowler, Melissa A, Athanacio, Jon, Kredel, Taylor A, Antwan, Agnes, Johns, Michael, Tsivkovski, Oleg, Cruz, Shirley, Luo, Rosa, Reinhart, Greg, Kusnetzow, Ana Karin, Madan, Ajay, Betz, Stephen F, Struthers, Scott

“…Cushing’s disease (CD) and Ectopic ACTH syndrome (EAS) stem from excess circulating adrenocorticotropic hormone (ACTH) and resulting hypercortisolemia. In CD,…”
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SAT-169 Selective Nonpeptide Somatostatin Subtype 5 (sst5) Agonists Suppress Glucose- and Sulfonylurea-Induced Insulin Secretion in Rats by Sturchler, Emmanuel, Fowler, Melissa, Athanacio, Jon, Kredel, Taylor, Johns, Michael, Zhao, Jian, Wang, Shimiao, Luo, Rosa, Kusnetzow, Ana, Zhu, Yun Fei, Madan, Ajay, Struthers, Scott, Betz, Stephen, Markison, Stacy

“…Congenital hyperinsulinism (CHI) results from mutations within the insulin secretion pathway and is characterized by excessive and/or inappropriate insulin…”
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SAT-364 Nonpeptide Orally-Bioavailable ACTH Antagonists: Suppression of ACTH-Induced Corticosterone Secretion and Adrenal Hypertrophy in Rats by Kusnetzow, Ana, Fowler, Melissa, Athanacio, Jon, Reinhart, Greg, Rico-Bautista, Elizabeth, Han, Sangdon, Kim, Sun Hee, Johns, Michael, Kredel, Taylor, Nguyen, Julie, Staley, Christine, Tan, Hannah, Luo, Rosa, Markison, Stacy, Madan, Ajay, Zhu, Yun Fei, Struthers, Scott, Betz, Stephen

“…Cushing’s disease is most commonly the result of a microadenoma derived from pituitary corticotrophic cells that secretes excess adrenocorticotropic hormone…”
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MON-089 Discovery and Identification of Late Stage Selective Nonpeptide Somatostatin Subtype 5 (sst5) Agonists for the Treatment of Hyperinsulinemic Hypoglycemia by Fowler, Melissa A, Zhao, Jian, Sturchler, Emmanuel, Rico, Elizabeth, de Necochea-Campion, Rosalia, Athanacio, Jon, Kredel, Taylor A, Antwan, Agnes, Johns, Michael, Tsivkovski, Oleg, Wang, Shmiao, Luo, Rosa, Kusnetzow, Ana Karin, Madan, Ajay, Struthers, Scott, Markison, Stacy, Zhu, Yun Fei, Betz, Stephen F

“…Congenital hyperinsulinism (CHI) results from mutations within the insulin secretion pathway and is characterized by excessive and/or inappropriate insulin…”
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MON-176 Discovery and Identification of Late Stage Selective Nonpeptide ACTH Antagonists for the Treatment of Cushing’s Disease, Ectopic ACTH Secreting Tumors, and Congenital Adrenal Hyperplasia by Kusnetzow, Ana Karin, Han, Sangdon, Fowler, Melissa A, Athanacio, Jon, Reinhart, Greg, Rico, Elizabeth, Kim, Sun Hee, Johns, Michael, Kredel, Taylor A, Antwan, Agnes, Tsivkovski, Oleg, Nguyen, Julie, Staley, Christine, Tan, Hannah, Luo, Rosa, Markison, Stacy, Madan, Ajay, Zhu, Yun Fei, Struthers, Scott, Betz, Stephen F

“…Adrenocorticotropic hormone (ACTH) is an important modulator of steroidal hormone synthesis and secretion from the adrenal gland and its selective activity at…”
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