Comparative transcriptome of normal and cancer-associated fibroblasts

The characteristics of a tumor are largely determined by its interaction with the surrounding micro-environment (TME). TME consists of both cellular and non-cellular components. Cancer-associated fibroblasts (CAFs) are a major component of the TME. They are a source of many secreted factors that inf...

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Published in:	BMC cancer Vol. 24; no. 1; pp. 1231 - 31
Main Authors:	Abikar, Apoorva, Mustafa, Mohammad Mehaboob Subhani, Athalye, Radhika Rajiv, Nadig, Namratha, Tamboli, Ninad, Babu, Vinod, Keshavamurthy, Ramaiah, Ranganathan, Prathibha
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 05-10-2024 BioMed Central BMC
Subjects:	Analysis Biological markers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Cancer therapies Cancer-associated fibroblasts Cancer-Associated Fibroblasts - metabolism Cancer-Associated Fibroblasts - pathology Care and treatment Chemoresistance Chemotherapy Complications and side effects Cytokines Drug resistance Extracellular matrix Fibroblasts Fibroblasts - metabolism Gene Expression Profiling Gene Expression Regulation, Neoplastic Genomes Growth factors Health aspects Humans Hyperplasia Kinases LINCRNA Male Metabolism Metabolites Metastasis MicroRNAs MicroRNAs - genetics miRNA Non-coding RNA Patient outcomes Prostate Prostate cancer Prostatic Hyperplasia - genetics Prostatic Hyperplasia - metabolism Prostatic Hyperplasia - pathology Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology RNA, Long Noncoding - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Transcriptome Transcriptomes Tumor microenvironment Tumor Microenvironment - genetics Urology India Cancer-associated fibroblasts Tumor microenvironment LINCRNA Non-coding RNA Prostate cancer Chemoresistance
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Summary:	The characteristics of a tumor are largely determined by its interaction with the surrounding micro-environment (TME). TME consists of both cellular and non-cellular components. Cancer-associated fibroblasts (CAFs) are a major component of the TME. They are a source of many secreted factors that influence the survival and progression of tumors as well as their response to drugs. Identification of markers either overexpressed in CAFs or unique to CAFs would pave the way for novel therapeutic strategies that in combination with conventional chemotherapy are likely to have better patient outcome. Fibroblasts have been derived from Benign Prostatic Hyperplasia (BPH) and prostate cancer. RNA from these has been used to perform a transcriptome analysis in order to get a comparative profile of normal and cancer-associated fibroblasts. The study has identified 818 differentially expressed mRNAs and 17 lincRNAs between normal and cancer-associated fibroblasts. Also, 15 potential lincRNA-miRNA-mRNA combinations have been identified which may be potential biomarkers. This study identified differentially expressed markers between normal and cancer-associated fibroblasts that would help in targeted therapy against CAFs/derived factors, in combination with conventional therapy. However, this would in future need more experimental validation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1471-2407 1471-2407
DOI:	10.1186/s12885-024-13006-x