Search Results - "Ates, Louis S"

Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria by Ates, Louis S, Ummels, Roy, Commandeur, Susanna, van de Weerd, Robert, van der Weerd, Robert, Sparrius, Marion, Weerdenburg, Eveline, Alber, Marina, Kalscheuer, Rainer, Piersma, Sander R, Abdallah, Abdallah M, Abd El Ghany, Moataz, Abdel-Haleem, Alyaa M, Pain, Arnab, Jiménez, Connie R, Bitter, Wilbert, Houben, Edith N G

“…Mycobacteria possess different type VII secretion (T7S) systems to secrete proteins across their unusual cell envelope. One of these systems, ESX-5, is only…”
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The ESX-5 System of Pathogenic Mycobacteria Is Involved In Capsule Integrity and Virulence through Its Substrate PPE10 by Ates, Louis S, van der Woude, Aniek D, Bestebroer, Jovanka, van Stempvoort, Gunny, Musters, René J P, Garcia-Vallejo, Juan J, Picavet, Daisy I, Weerd, Robert van de, Maletta, Massimiliano, Kuijl, Coenraad P, van der Wel, Nicole N, Bitter, Wilbert

“…Mycobacteria produce a capsule layer, which consists of glycan-like polysaccharides and a number of specific proteins. In this study, we show that, in…”
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Marine sponge microbe provides insights into evolution and virulence of the tubercle bacillus by Pidot, Sacha J, Klatt, Stephan, Ates, Louis S, Frigui, Wafa, Sayes, Fadel, Majlessi, Laleh, Izumi, Hiroshi, Monk, Ian R, Porter, Jessica L, Bennett-Wood, Vicki, Seemann, Torsten, Otter, Ashley, Taiaroa, George, Cook, Gregory M, West, Nicholas, Tobias, Nicholas J, Fuerst, John A, Stutz, Michael D, Pellegrini, Marc, McConville, Malcolm, Brosch, Roland, Stinear, Timothy P

“…Reconstructing the evolutionary origins of Mycobacterium tuberculosis, the causative agent of human tuberculosis, has helped identify bacterial factors that…”
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New insights into the mycobacterial PE and PPE proteins provide a framework for future research by Ates, Louis S.

“…Summary The PE and PPE proteins of Mycobacterium tuberculosis have been studied with great interest since their discovery. Named after the conserved proline…”
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RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection by Ates, Louis S, Sayes, Fadel, Frigui, Wafa, Ummels, Roy, Damen, Merel P M, Bottai, Daria, Behr, Marcel A, van Heijst, Jeroen W J, Bitter, Wilbert, Majlessi, Laleh, Brosch, Roland

“…Tuberculosis is the deadliest infectious disease worldwide. Although the BCG vaccine is widely used, it does not efficiently protect against pulmonary…”
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Optimization of secretion and surface localization of heterologous OVA protein in mycobacteria by using LipY as a carrier by Burggraaf, Maroeska J, Ates, Louis S, Speer, Alexander, van der Kuij, Kim, Kuijl, Coen, Bitter, Wilbert

“…Mycobacterium bovis Bacille Calmette-Guérin (BCG) is not only used as a vaccine against tuberculosis but also protects against leprosy and is used as part of…”
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Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors by Sayes, Fadel, Blanc, Catherine, Ates, Louis S., Deboosere, Nathalie, Orgeur, Mickael, Le Chevalier, Fabien, Gröschel, Matthias I., Frigui, Wafa, Song, Ok-Ryul, Lo-Man, Richard, Brossier, Florence, Sougakoff, Wladimir, Bottai, Daria, Brodin, Priscille, Charneau, Pierre, Brosch, Roland, Majlessi, Laleh

“…The pathogenic potential of Mycobacterium tuberculosis largely depends on ESX secretion systems exporting members of the multigenic Esx, Esp, and PE/PPE…”
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Ectopic expression of cGAS in Salmonella typhimurium enhances STING-mediated IFN-β response in human macrophages and dendritic cells by Waanders, Lisette, van der Donk, Lieve E H, Ates, Louis S, Maaskant, Janneke, van Hamme, John L, Eldering, Eric, van Bruggen, Jaco A C, Rietveld, Joanne M, Bitter, Wilbert, Geijtenbeek, Teunis B H, Kuijl, Coenraad P

“…BackgroundInterferon (IFN)-β induction via activation of the stimulator of interferon genes (STING) pathway has shown promising results in tumor models. STING…”
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Separate signaling events control TCR downregulation and T cell activation in primary human T cells by Donk, Lieve E. H., Ates, Louis S., Spek, Jet, Tukker, Laura M., Geijtenbeek, Teunis B. H., Heijst, Jeroen W. J.

“…Introduction T‐cell antigen receptor (TCR) interaction with cognate peptide:MHC complexes trigger clustering of TCR:CD3 complexes and signal transduction…”
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An optimized retroviral toolbox for overexpression and genetic perturbation of primary lymphocytes by van der Donk, Lieve E H, van der Spek, Jet, van Duivenvoorde, Tom, Ten Brink, Marieke S, Geijtenbeek, Teunis B H, Kuijl, Coenraad P, van Heijst, Jeroen W J, Ates, Louis S

“…Genetic manipulation of primary lymphocytes is crucial for both clinical purposes and fundamental research. Despite their broad use, we encountered a paucity…”
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Discovery of the type VII ESX‐1 secretion needle? by Ates, Louis S., Brosch, Roland

“…Summary Mycobacterium tuberculosis, the etiological agent of human tuberculosis, harbours five ESAT‐6/type VII secretion (ESX/T7S) systems. The first esx gene…”
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Type VII Secretion: A Highly Versatile Secretion System by Ates, Louis S, Houben, Edith N G, Bitter, Wilbert

“…Type VII secretion (T7S) systems of mycobacteria secrete substrates over the unusual diderm cell envelope. Furthermore, T7S gene clusters are present…”
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Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis by Ates, Louis S., Dippenaar, Anzaan, Ummels, Roy, Piersma, Sander R., van der Woude, Aniek D., van der Kuij, Kim, Le Chevalier, Fabien, Mata-Espinosa, Dulce, Barrios-Payán, Jorge, Marquina-Castillo, Brenda, Guapillo, Carolina, Jiménez, Connie R., Pain, Arnab, Houben, Edith N. G., Warren, Robin M., Brosch, Roland, Hernández-Pando, Rogelio, Bitter, Wilbert

“…Mycobacterium tuberculosis requires a large number of secreted and exported proteins for its virulence, immune modulation and nutrient uptake. Most of these…”
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Unexpected Genomic and Phenotypic Diversity of Mycobacterium africanum Lineage 5 Affects Drug Resistance, Protein Secretion, and Immunogenicity by Ates, Louis S, Dippenaar, Anzaan, Sayes, Fadel, Pawlik, Alexandre, Bouchier, Christiane, Ma, Laurence, Warren, Robin M, Sougakoff, Wladimir, Majlessi, Laleh, van Heijst, Jeroen W J, Brossier, Florence, Brosch, Roland

“…Mycobacterium africanum consists of Lineages L5 and L6 of the Mycobacterium tuberculosis complex (MTBC) and causes human tuberculosis in specific regions of…”
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Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts by Orgeur, Mickael, Frigui, Wafa, Pawlik, Alexandre, Clark, Simon, Williams, Ann, Ates, Louis S, Ma, Laurence, Bouchier, Christiane, Parkhill, Julian, Brodin, Priscille, Brosch, Roland

“…is an animal-adapted member of the complex (MTBC), which was originally isolated from voles, but has more recently also been isolated from other selected…”
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D iscovery of the type VII ESX‐1 secretion needle? by Ates, Louis S., Brosch, Roland

“…Summary Mycobacterium tuberculosis , the etiological agent of human tuberculosis, harbours five ESAT‐6/type VII secretion (ESX/T7S) systems. The first esx gene…”
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Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria: e1005190 by Ates, Louis S, Ummels, Roy, Commandeur, Susanna, Weerd, Robert vander, Sparrius, Marion, Weerdenburg, Eveline, Alber, Marina, Kalscheuer, Rainer, Piersma, Sander R, Abdallah, Abdallah M, Ghany, Moataz AbdEl, Abdel-Haleem, Alyaa M, Pain, Arnab, Jiménez, Connie R, Bitter, Wilbert, Houben, Edith NG

“…Mycobacteria possess different type VII secretion (T7S) systems to secrete proteins across their unusual cell envelope. One of these systems, ESX-5, is only…”
Get full text