Pancreatic fistulae after pancreatic resections for neuroendocrine tumours compared with resections for other lesions

Pancreatic fistulae after pancreatic resections for neuroendocrine tumours compared with resections for other lesions

Abstract Background Resection for pancreatic neuroendocrine tumours (PNET) is suggested to be associated with an increased risk of a post-operative pancreatic fistula (POPF). The aim of this study was to describe morbidity after resections for PNET, focusing on POPF. Outcomes were compared with rese...

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Bibliographic Details
Published in:HPB (Oxford, England) Vol. 17; no. 1; pp. 38 - 45
Main Authors: Atema, Jasper Jan, Jilesen, Anneke P.J, Busch, Olivier R.C, van Gulik, Thomas M, Gouma, Dirk J, Nieveen van Dijkum, Els J.M
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-01-2015
Wiley Subscription Services, Inc
BlackWell Publishing Ltd
Subjects:
Adult
Aged
Chi-Square Distribution
Confidence intervals
Female
Gastroenterology and Hepatology
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Neuroendocrine Tumors - pathology
Neuroendocrine Tumors - surgery
Odds Ratio
Original
Pancreas
Pancreatectomy - adverse effects
Pancreatic Fistula - diagnosis
Pancreatic Fistula - etiology
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - surgery
Retrospective Studies
Risk Factors
Treatment Outcome
Tumors
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Summary:Abstract Background Resection for pancreatic neuroendocrine tumours (PNET) is suggested to be associated with an increased risk of a post-operative pancreatic fistula (POPF). The aim of this study was to describe morbidity after resections for PNET, focusing on POPF. Outcomes were compared with resections for other lesions. Methods Patients undergoing an elective pancreatic resection during a 12-year period were retrospectively analysed. Morbidity was defined according to the International Study Group of Pancreatic Surgery (ISGPS) definitions. Results Eighty-eight out of 832 patients (10.6%) underwent a resection for PNET. Atypical pancreatic resections (enucleation and central pancreatectomy) and distal pancreatectomies were more frequently performed for PNET. The POPF rate was 22.7% in patients operated for PNET compared with 17.2% in other patients ( P = 0.200). In univariate analysis, body mass index (BMI), pancreatic duct diameter, somatostatin analogue administration, type of resection and type of pathology were associated with a POPF. In multivariate analysis, BMI, a pancreatic duct diameter <3 mm and central pancreatectomy remained independent risk factors [odds ratio (OR) 1.93, 95% confidence interval (CI) 1.22–3.07 and OR 3.04, 95% CI 1.05–8.82, respectively]. Conclusions High rates of POPF were found in patients operated for PNET. However, this was mainly owing to the fact that atypical resections, known to be associated with a higher fistula rate, were performed more frequently in these patients.
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ISSN:1365-182X
1477-2574
DOI:10.1111/hpb.12319