Search Results - "Atatreh, Noor"

Structure-based assessment and druggability classification of protein–protein interaction sites by Alzyoud, Lara, Bryce, Richard A., Al Sorkhy, Mohammad, Atatreh, Noor, Ghattas, Mohammad A.

“…The featureless interface formed by protein–protein interactions (PPIs) is notorious for being considered a difficult and poorly druggable target. However,…”
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The Discovery of Potent SHP2 Inhibitors with Anti-Proliferative Activity in Breast Cancer Cell Lines by Ghemrawi, Rose, Khair, Mostafa, Hasan, Shaima, Aldulaymi, Raghad, AlNeyadi, Shaikha S, Atatreh, Noor, Ghattas, Mohammad A

“…Despite available treatments, breast cancer is the leading cause of cancer-related death. Knowing that the tyrosine phosphatase SHP2 is a regulator in…”
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The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological Evaluation by Mahgoub, Radwa E, Mohamed, Feda E, Alzyoud, Lara, Ali, Bassam R, Ferreira, Juliana, Rabeh, Wael M, AlNeyadi, Shaikha S, Atatreh, Noor, Ghattas, Mohammad A

“…The main protease enzyme (Mpro) of SARS-CoV-2 is one of the most promising targets for COVID-19 treatment. Accordingly, in this work, a structure-based virtual…”
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Discovery of new butyrylcholinesterase inhibitors via structure-based virtual screening by Atatreh, Noor, Al Rawashdah, Sara, Al Neyadi, Shaikha S., Abuhamdah, Sawsan M., Ghattas, Mohammad A.

“…Butyrylcholinesterase (BChE) plays an important role in the progression of the Alzheimer's disease. In this study, we used a structure-based virtual screening…”
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Molecular Modelling Study and Antibacterial Evaluation of Diphenylmethane Derivatives as Potential FabI Inhibitors by Hasan, Shaima, Kayed, Kawthar, Ghemrawi, Rose, Bataineh, Nezar Al, Mahgoub, Radwa E, Audeh, Rola, Aldulaymi, Raghad, Atatreh, Noor, Ghattas, Mohammad A

“…The need for new antibiotics has become a major worldwide challenge as bacterial strains keep developing resistance to the existing drugs at an alarming rate…”
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Computer-aided approaches reveal trihydroxychroman and pyrazolone derivatives as potential inhibitors of SARS-CoV-2 virus main protease by Atatreh, Noor, Hasan, Shaima, Ali, Bassam R., Ghattas, Mohammad A.

“…COVID-19 was declared a pandemic by the World Health Organization (WHO) in March 2020. The disease is caused by severe acute respiratory syndrome coronavirus 2…”
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Controlled Release of Pyrimidine Compound Using Polymeric Coated ZIF-8 Metal-Organic Framework as Glucagon-Like Peptide-1 Receptor Agonist Carrier by AlNeyadi, Shaikha S, Amir, Naheed, Ghattas, Mohammad A, Atatreh, Noor, Alketbi, Shaikha S, Ajeil, Ruba Al, Adem, Abdu

“…This work demonstrates synthetic strategies for the incorporation of a synthesized pyrimidine glucagon-like peptide-1 (GLP-1) agonist into alginate-coated…”
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Anti-inflammatory drug approach: Synthesis and biological evaluation of novel pyrazolo[3,4-d]pyrimidine compounds by Atatreh, Noor, Youssef, Amal M., Ghattas, Mohammad A., Al Sorkhy, Mohammad, Alrawashdeh, Sara, Al-Harbi, Khaled B., El-Ashmawy, Ibrahim M., Almundarij, Tariq I., Abdelghani, Amani A., Abd-El-Aziz, Alaa S.

“…The present work describes the design and synthesis of novel series of ten pyrazolo[3,4-d]pyrazolo derivatives. Four compounds 3a, 3d, 4d and 4f were notable…”
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The Effects of Medications and the Roles of Pharmacists on the Recovery of Patients with COVID-19 Infection: An Epidemiological Study from the United Arab Emirates by Basheti, Iman A, Barqawi, Hiba, Nassar, Razan I, Thiab, Samar, Atatreh, Noor, Abu-Gharbieh, Eman

“…Patients infected with coronavirus have new experiences and hence new needs from the healthcare sector. Acknowledging patients' experiences can exhibit…”
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Activation of the GLP-1 receptor by chloropyrimidine derivatives by AlNeyadi, Shaikha S., Adem, Abdu, Amer, Naheed, Ghattas, Mohammad A, Atatreh, Noor, Salem, Alaa A., Abdou, Ibrahim M.

“…•Two substituted pyrimidine series 2a-k and 4a-k we examined as antidiabetic agents.•The in-vitro and in-vivo results showed that compound 2c and 2f are the…”
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Boosting the Accuracy and Chemical Space Coverage of the Detection of Small Colloidal Aggregating Molecules Using the BAD Molecule Filter by Abou Hajal, Abdallah, Bryce, Richard A., Amor, Boulbaba Ben, Atatreh, Noor, Ghattas, Mohammad A.

“…The ability to conduct effective high throughput screening (HTS) campaigns in drug discovery is often hampered by the detection of false positives in these…”
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How Do Small Molecule Aggregates Inhibit Enzyme Activity? A Molecular Dynamics Study by Ghattas, Mohammad A, Al Rawashdeh, Sara, Atatreh, Noor, Bryce, Richard A

“…Small molecule compounds which form colloidal aggregates in solution are problematic in early drug discovery; adsorption of the target protein by these…”
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Allosteric Binding Sites of the SARS-CoV-2 Main Protease: Potential Targets for Broad-Spectrum Anti-Coronavirus Agents by Alzyoud, Lara, Ghattas, Mohammad A, Atatreh, Noor

“…The current pandemic caused by the COVID-19 disease has reached everywhere in the world and has affected every aspect of our lives. As of the current data, the…”
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Antibacterial activity and mechanism of action of the benzazole acrylonitrile-based compounds: In vitro, spectroscopic, and docking studies by AlNeyadi, Shaikha S., Salem, Alaa A., Ghattas, Mohammad A., Atatreh, Noor, Abdou, Ibrahim M.

“…A new series of pyrimidine derivatives 5, 9a-d and 12a-d was synthesized by an efficient procedure. The antibacterial activity of the new compounds was studied…”
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Discovery of pyrimidoindol and benzylpyrrolyl inhibitors targeting SARS-CoV-2 main protease (M pro ) through pharmacophore modelling, covalent docking, and biological evaluation by Mahgoub, Radwa E, Mohamed, Feda E, Ali, Bassam R, Ferreira, Juliana, Rabeh, Wael M, Atatreh, Noor, Ghattas, Mohammad A

“…The main protease (M ) enzyme has an imperative function in disease progression and the life cycle of the SARS-CoV-2 virus. Although the orally active drug…”
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The Discovery of Novel Small Oxindole‐Based Inhibitors Targeting the SARS‐CoV‐2 Main Protease (Mpro) by Alzyoud, Lara, Mahgoub, Radwa E., Mohamed, Feda E., Ali, Bassam R., Ferreira, Juliana, Rabeh, Wael M., Atatreh, Noor, Ghattas, Mohammad A.

“…With the potential for coronaviruses to re‐emerge and trigger future pandemics, the urgent development of antiviral inhibitors against SARS‐CoV‐2 is essential…”
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Abstract B45: Molecular modeling approach for exploring the MDM2 active site for the discovery of new P53-MDM2 inhibitors by Atatreh, Noor, Mansour, Ramez A., Ghattas, Mohammad A.

“…Abstract MDM2 is a protein that regulates the action of tumor suppressor protein P53. Inhibiting the interaction between the two proteins is widely considered…”
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Abstract B44: Druggability assessment of protein tyrosine phosphatase binding site by Ghattas, Mohammad A., Raslan, Noor, Sadeq, Asil, Atatreh, Noor

“…Abstract Protein tyrosine phosphatases play important roles in the signalling system in our bodies and were observed to be overexpressed in many diseases. For…”
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Assessing adherence to medications: Is there a difference between a subjective method and an objective method, or between using them concurrently? by Nassar, Razan I., Saini, Bandana, Obeidat, Nathir M., Atatreh, Noor, Basheti, Iman A.

“…Background: Patients’ adherence to medication can be assessed by several subjective or objective methods. The Global Initiative for Asthma (GINA) has…”
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Structure‐based drug design and in vitro testing reveal new inhibitors of enoyl‐acyl carrier protein reductases by Ghattas, Mohammad A., Eissa, Nermin A., Tessaro, Francesca, Perozzo, Remo, Scapozza, Leonardo, Obaid, Dana, Atatreh, Noor

“…The need for new antibacterial agents is increasingly becoming of great importance as bacterial resistance to current drugs is quickly spreading. Enoyl‐acyl…”
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