Search Results - "Atanasova, Kalina R"

Strategies for measuring airway mucus and mucins by Atanasova, Kalina R, Reznikov, Leah R

“…Mucus secretion and mucociliary transport are essential defense mechanisms of the airways. Deviations in mucus composition and secretion can impede mucociliary…”
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Prelude to oral microbes and chronic diseases: past, present and future by Atanasova, Kalina R., Yilmaz, Özlem

“…Associations between oral and systemic health are ancient. Oral opportunistic bacteria, particularly, Porphyromonas gingivalis and Fusobacterium nucleatum,…”
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Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis by Atanasova, Kalina R, Reznikov, Leah R

“…The nervous system mediates key airway protective behaviors, including cough, mucus secretion, and airway smooth muscle contraction. Thus, its involvement and…”
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Human Primary Epithelial Cells Acquire an Epithelial-Mesenchymal-Transition Phenotype during Long-Term Infection by the Oral Opportunistic Pathogen, Porphyromonas gingivalis by Lee, Jungnam, Roberts, JoAnn S, Atanasova, Kalina R, Chowdhury, Nityananda, Han, Kyudong, Yilmaz, Özlem

“…is a host-adapted oral pathogen associated with chronic periodontitis that successfully survives and persists in the oral epithelium. Recent studies have…”
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Porphyromonas gingivalis traffics into endoplasmic reticulum-rich-autophagosomes for successful survival in human gingival epithelial cells by Lee, Kyulim, Roberts, JoAnn S., Choi, Chul Hee, Atanasova, Kalina R., Yilmaz, Özlem

“…Porphyromonas gingivalis, an opportunistic pathogen usurps gingival epithelial cells (GECs) as primary intracellular niche for its colonization in the oral…”
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Epigenetic small-molecule screen for inhibition and reversal of acinar ductal metaplasia in mouse pancreatic organoids by Atanasova, Kalina R, Perkins, Corey M, Ratnayake, Ranjala, Jiang, Jinmai, Chen, Qi-Yin, Schmittgen, Thomas D, Luesch, Hendrik

“…Acinar ductal metaplasia (ADM) is among the earliest initiating events in pancreatic ductal adenocarcinoma (PDAC) development. We developed a novel…”
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Opportunistic Pathogen Porphyromonas gingivalis Modulates Danger Signal ATP-Mediated Antibacterial NOX2 Pathways in Primary Epithelial Cells by Roberts, JoAnn S, Atanasova, Kalina R, Lee, Jungnam, Diamond, Gill, Deguzman, Jeff, Hee Choi, Chul, Yilmaz, Özlem

“…, a major opportunistic pathogen in the etiology of chronic periodontitis, successfully survives in human gingival epithelial cells (GECs). abrogates the…”
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In Situ Intraepithelial Localizations of Opportunistic Pathogens, Porphyromonas gingivalis and Filifactor alocis, in Human Gingiva by Lee, Jaden S., Spooner, Ralee, Chowdhury, Nityananda, Pandey, Vivek, Wellslager, Bridgette, Atanasova, Kalina R., Evans, Zachary, Yilmaz, Özlem

“…•The gingival epithelium serves as a growth reservoir for opportunistic bacteria.•Intraepithelial P. gingivalis and F. alocis colonies are detected together in…”
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Overexpression of Substance P in pig airways increases MUC5AC through an NF‐kβ pathway by Sponchiado, Mariana, Liao, Yan‐Shin, Atanasova, Kalina R., Collins, Emily N., Schurmann, Veronica, Bravo, Laura, Reznikov, Leah R.

“…Substance P (SP) is a tachykinin that regulates airway mucous secretion in both health and disease. Our study aimed to determine whether overexpression of SP…”
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Vibrio cholerae persisted in microcosm for 700 days inhibits motility but promotes biofilm formation in nutrient-poor lake water microcosms by Jubair, Mohammad, Atanasova, Kalina R, Rahman, Mustafizur, Klose, Karl E, Yasmin, Mahmuda, Yilmaz, Ozlem, Morris, Jr, J Glenn, Ali, Afsar

“…Toxigenic Vibrio cholerae, ubiquitous in aquatic environments, is responsible for cholera; humans can become infected after consuming food and/or water…”
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Inflammasome Activation in Gingival Epithelial Cells by Atanasova, Kalina R, Yilmaz, Özlem

“…Inflammasomes are multiprotein complexes that assemble in host cells upon recognition of infection or danger via pattern recognition receptors and/or danger…”
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Targeted and functional genomics approaches to the mechanism of action of lagunamide D, a mitochondrial cytotoxin from marine cyanobacteria by Luo, Danmeng, Ratnayake, Ranjala, Atanasova, Kalina R., Paul, Valerie J., Luesch, Hendrik

“…[Display omitted] Lagunamide D, a cyanobacterial cyclodepsipeptide, exhibits potent antiproliferative activity against HCT116 colorectal cancer cells (IC50…”
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NLRX1 modulates differentially NLRP3 inflammasome activation and NF-κB signaling during Fusobacterium nucleatum infection by Hung, Shu-Chen, Huang, Pei-Rong, Almeida-da-Silva, Cássio Luiz Coutinho, Atanasova, Kalina R., Yilmaz, Ozlem, Ojcius, David M.

“…NOD-like receptors (NLRs) play a large role in regulation of host innate immunity, yet their role in periodontitis remains to be defined. NLRX1, a member of…”
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An epigenetic small molecule screen to target abnormal nuclear morphology in human cells by Atanasova, Kalina R, Chakraborty, Saptarshi, Ratnayake, Ranjala, Khare, Kshitij D, Luesch, Hendrik, Lele, Tanmay P

“…Irregular nuclear shapes are a hallmark of human cancers. Recent studies suggest that alterations to chromatin regulators may cause irregular nuclear…”
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A novel kinase function of a nucleoside‐diphosphate‐kinase homologue in Porphyromonas gingivalis is critical in subversion of host cell apoptosis by targeting heat‐shock protein 27 by Lee, Jungnam, Roberts, JoAnn S., Atanasova, Kalina R., Chowdhury, Nityananda, Yilmaz, Özlem

“…We have previously shown that a homologue of a conserved nucleoside‐diphosphate‐kinase (Ndk) family of multifunctional enzymes and secreted molecule in…”
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High-throughput gene screen reveals modulators of nuclear shape by Tamashunas, Andrew C, Tocco, Vincent J, Matthews, James, Zhang, Qiao, Atanasova, Kalina R, Paschall, Lauren, Pathak, Shreya, Ratnayake, Ranjala, Stephens, Andrew D, Luesch, Hendrik, Licht, Jonathan D, Lele, Tanmay P

“…Irregular nuclear shapes characterized by blebs, lobules, micronuclei, or invaginations are hallmarks of many cancers and human pathologies. Despite the…”
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Porphyromonas gingivalis attenuates ATP-mediated inflammasome activation and HMGB1 release through expression of a nucleoside-diphosphate kinase by Johnson, Larry, Atanasova, Kalina R., Bui, Phuong Q., Lee, Jungnam, Hung, Shu-Chen, Yilmaz, Özlem, Ojcius, David M.

“…Many intracellular pathogens evade the innate immune response in order to survive and proliferate within infected cells. We show that Porphyromonas gingivalis,…”
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Chemical Genetics in C. elegans Identifies Anticancer Mycotoxins Chaetocin and Chetomin as Potent Inducers of a Nuclear Metal Homeostasis Response by Abraham, Elijah, Athapaththu, A. M. Gihan K., Atanasova, Kalina R., Chen, Qi-Yin, Corcoran, Taylor J., Piloto, Juan, Wu, Cheng-Wei, Ratnayake, Ranjala, Luesch, Hendrik, Choe, Keith P.

“…C. elegans numr-1/2 (nuclear-localized metal-responsive) is an identical gene pair encoding a nuclear protein previously shown to be activated by cadmium and…”
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Acid exposure disrupts mucus secretion and impairs mucociliary transport in neonatal piglet airways by Liao, Yan Shin J, Kuan, Shin Ping, Guevara, Maria V, Collins, Emily N, Atanasova, Kalina R, Dadural, Joshua S, Vogt, Kevin, Schurmann, Veronica, Bravo, Laura, Eken, Eda, Sponchiado, Mariana, Reznikov, Leah R

“…Tenacious mucus produced by tracheal and bronchial submucosal glands is a defining feature of several airway diseases, including cystic fibrosis (CF). Airway…”
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Airway cholinergic history modifies mucus secretion properties to subsequent cholinergic challenge in diminished chloride and bicarbonate conditions by Liao, Yan Shin J., Collins, Emily N., Guevara, Maria Valentina, Schurmann, Veronica, Atanasova, Kalina R., Bravo, Laura, Sponchiado, Mariana, Hoegger, Mark J., Reznikov, Leah R.

“…New Findings What is the central question of this study? What is the impact of airway cholinergic history on the properties of airway mucus secretion in a…”
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