Search Results - "Atack, Thomas"

Manganese-Catalyzed Borylation of Unactivated Alkyl Chlorides by Atack, Thomas C, Cook, Silas P

“…The use of low-cost manganese­(II) bromide (MnBr2) and tetramethyl­ethylene­diamine (TMEDA) catalyzes the cross coupling of (bis)­pinacolato­diboron with a…”
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Iron-Catalyzed Borylation of Alkyl Electrophiles by Atack, Thomas C, Lecker, Rachel M, Cook, Silas P

“…The use of low-cost iron­(III) acetoacetate (Fe­(acac)3) and tetra­methyl­ethylene­diamine (TMEDA) enables the direct cross-coupling of alkyl halides with…”
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Blocking Scn10a Channels in Heart Reduces Late Sodium Current and Is Antiarrhythmic by Yang, Tao, Atack, Thomas C, Stroud, Dina Myers, Zhang, Wei, Hall, Lynn, Roden, Dan M

“…RATIONALE:Although the sodium channel locus SCN10A has been implicated by genome-wide association studies as a modulator of cardiac electrophysiology, the role…”
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Systematic profiling of conditional degron tag technologies for target validation studies by Bondeson, Daniel P., Mullin-Bernstein, Zachary, Oliver, Sydney, Skipper, Thomas A., Atack, Thomas C., Bick, Nolan, Ching, Meilani, Guirguis, Andrew A., Kwon, Jason, Langan, Carly, Millson, Dylan, Paolella, Brenton R., Tran, Kevin, Wie, Sarah J., Vazquez, Francisca, Tothova, Zuzana, Golub, Todd R., Sellers, William R., Ianari, Alessandra

“…Conditional degron tags (CDTs) are a powerful tool for target validation that combines the kinetics and reversible action of pharmacological agents with the…”
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SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation by Savio-Galimberti, Eleonora, Weeke, Peter, Muhammad, Raafia, Blair, Marcia, Ansari, Sami, Short, Laura, Atack, Thomas C, Kor, Kaylen, Vanoye, Carlos G, Olesen, Morten Salling, LuCamp, Yang, Tao, George, Jr, Alfred L, Roden, Dan M, Darbar, Dawood

“…To test the hypothesis that vulnerability to atrial fibrillation (AF) is associated with rare coding sequence variation in the SCN10A gene, which encodes the…”
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Striking In Vivo Phenotype of a Disease-Associated Human SCN5A Mutation Producing Minimal Changes in Vitro by WATANABE, Hiroshi, TAO YANG, KUPERSHMIDT, Sabina, CHOPRA, Nagesh, MAGNUSON, Mark A, TANABE, Naohito, KNOLLMANN, Björn C, GEORGE, Alfred L, RODEN, Dan M, MYERS STROUD, Dina, LOWE, John S, HARRIS, Louise, ATACK, Thomas C, WANG, Dao W, HIPKENS, Susan B, LEAKE, Brenda, HALL, Lynn

“…The D1275N SCN5A mutation has been associated with a range of unusual phenotypes, including conduction disease and dilated cardiomyopathy, as well as atrial…”
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Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35 by Atack, Thomas C, Raymond, Donald D, Blomquist, Christa A, Pasaje, Charisse Flerida, McCarren, Patrick R, Moroco, Jamie, Befekadu, Henock B, Robinson, Foxy P, Pal, Debjani, Esherick, Lisl Y, Ianari, Alessandra, Niles, Jacquin C, Sellers, William R

“…FK506-binding protein 35, FKBP35, has been implicated as an essential malarial enzyme. Rapamycin and FK506 exhibit antiplasmodium activity in cultured…”
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Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice by LOWE, John S, MYERS STROUD, Dina, TAO YANG, HALL, Lynn, ATACK, Thomas C, RODEN, Dan M

“…Female gender is a risk factor for long QT-related arrhythmias, but the underlying mechanisms remain uncertain. Here, we tested the hypothesis that…”
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Contrasting Nav1.8 Activity in Scn10a−/− Ventricular Myocytes and the Intact Heart by Stroud, Dina Myers, Yang, Tao, Bersell, Kevin, Kryshtal, Dymtro O., Nagao, Satomi, Shaffer, Christian, Short, Laura, Hall, Lynn, Atack, Thomas C., Zhang, Wei, Knollmann, Bjorn C., Baudenbacher, Franz, Roden, Dan M.

“…Background Genome‐wide association studies have implicated variants in SCN10A, which encodes Nav1.8, as modulators of cardiac conduction. Follow‐up work has…”
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Informatic and Functional Approaches to Identifying a Regulatory Region for the Cardiac Sodium Channel by Atack, Thomas C, Myers Stroud, Dina, Watanabe, Hiroshi, Yang, Tao, Hall, Lynn, Hipkens, Susan B, Lowe, John S, Leake, Brenda, Magnuson, Mark A, Yang, Ping, Roden, Dan M

“…RATIONALE:Although multiple lines of evidence suggest that variable expression of the cardiac sodium channel gene SCN5A plays a role in susceptibility to…”
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Variants in the SCN5A Promoter Associated With Various Arrhythmia Phenotypes by Yagihara, Nobue, Watanabe, Hiroshi, Barnett, Phil, Duboscq‐Bidot, Laetitia, Thomas, Atack C., Yang, Ping, Ohno, Seiko, Hasegawa, Kanae, Kuwano, Ryozo, Chatel, Stéphanie, Redon, Richard, Schott, Jean‐Jacques, Probst, Vincent, Koopmann, Tamara T., Bezzina, Connie R., Wilde, Arthur A. M., Nakano, Yukiko, Aiba, Takeshi, Miyamoto, Yoshihiro, Kamakura, Shiro, Darbar, Dawood, Donahue, Brian S., Shigemizu, Daichi, Tanaka, Toshihiro, Tsunoda, Tatsuhiko, Suda, Masayoshi, Sato, Akinori, Minamino, Tohru, Endo, Naoto, Shimizu, Wataru, Horie, Minoru, Roden, Dan M., Makita, Naomasa

“…Background Mutations in the coding sequence of SCN5A, which encodes the cardiac Na+ channel α subunit, have been associated with inherited susceptibility to…”
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Abstract B037: Hit-finding by Cysteine-Scanning (HCS): A method for finding druggable pockets by van Tienen, Laurens Moore, Bayoumi, Shadwa, Muneeruddin, Khaja, Leymarie, Nancy, Kornfilt, David, Bian, Yuemin, Kesar, Devishi, Li, Ruitong, Atack, Thomas, Popa, Alexandra-Mariela, Jandova, Zuzana, Trollmann, Philipp, Bergner, Andreas, Rumpel, Klaus, Kessler, Dirk, Sellers, William R.

“…Abstract Large-scale cancer sequencing efforts coupled with deep functional genomic interrogation of cancer models provides us an increasingly detailed view of…”
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The evaluation of the National Learning Network by Caven-Atack, Andrew S. Thomas

“…The National Learning Network (NLN) is part of a response to the expectation that the further education (FE) sector within England will grow steadily over the…”
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Abstract 18645: Rare SCN10A Variants Associated With Lone Atrial Fibrillation Modulate Peak and Late Sodium Currents by Savio Galimberti, Eleonora, Weeke, Peter, Vanoye, Carlos G, Yang, Tao, Kor, Kaylen C, Atack, Thomas, George, Alfred L, Roden, Dan M, Darbar, Dawood

“…Abstract only Introduction: SCN10A encodes the sodium channel isoform Nav1.8, which is variably expressed in atria and has been linked to altered cardiac…”
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The Iron- and Manganese-Catalyzed Borylations of Alkyl Electrophiles: From Reactivity to Kinetics by Atack, Thomas Christopher

“…Alkylboronic esters are a versatile class of reagents with broad utility across synthesis and methodology. Their uses range from C–C cross-couplings to C–X…”
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Abstract 1531: SCN5A Promoter and Enhancer Variants associated with Atrial Fibrillation by Watanabe, Hiroshi, Darbar, Dawood, Atack, Thomas C, Yang, Ping, Ritchie, Marylyn D, Turner, Stephen, Ingram, Christiana R, Roden, Dan M

“…Abstract only We have recently reported that 5.9% of patients with atrial fibrillation (AF) have rare variants in the coding region of the predominant cardiac…”
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