Search Results - "Asymmetric Catalysis Special Feature Part II"

New Mechanistic Studies on the Proline-Catalyzed Aldol Reaction by List, Benjamin, Hoang, Linh, Martin, Harry J., Trost, Barry M.

“…The mechanism of the proline-catalyzed aldol reaction has stimulated considerable debate, and despite limited experimental data, at least five different…”
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Enantioselective Direct Aldol Reactions Catalyzed by L-Prolinamide Derivatives by Tang, Zhuo, Jiang, Fan, Cui, Xin, Gong, Liu-Zhu, Mi, Ai-Qiao, Jiang, Yao-Zhong, Wu, Yun-Dong, Halpern, Jack

“…L-Prolinamides 2, prepared from L-proline and simple aliphatic and aromatic amines, have been found to be active catalysts for the direct adol reaction of…”
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Controlling the Enantioselectivity of Enzymes by Directed Evolution: Practical and Theoretical Ramifications by Reetz, Manfred T., Halpern, Jack

“…A fundamentally new approach to asymmetric catalysis in organic chemistry is described based on the in vitro evolution of enantioselective enzymes. It…”
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Asymmetric Autocatalysis and Its Implications for the Origin of Homochirality by Blackmond, Donna G., Halpern, Jack

“…An autocatalytic reaction in which the reaction product serves as a catalyst to produce more of itself and to suppress production of its enantiomer serves as a…”
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Enantioselective Diels-Alder Reactions Catalyzed by Hydrogen Bonding by Thadani, Avinash N., Stankovic, Ana R., Rawal, Viresh H., Trost, Barry M.

“…Like molecules of life (e.g., proteins and DNA), many pharmaceutical drugs are also asymmetric (chiral); they are not superimposable on their mirror images…”
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Cu(I)-Catalyzed Direct Addition and Asymmetric Addition of Terminal Alkynes to Imines by Wei, Chunmei, Mague, Joel T., Li, Chao-Jun, Trost, Barry M.

“…A Cu(I)-catalyzed direct addition of alkynes to imines was developed. The process is simple and provides a diverse range of propargylamines in high…”
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Development of an Efficient, Scalable, Aldolase-Catalyzed Process for Enantioselective Synthesis of Statin Intermediates by Greenberg, William A., Varvak, Alexander, Hanson, Sarah R., Wong, Kelvin, Huang, Hongjun, Chen, Pei, Burk, Mark J., Trost, Barry M.

“…A process is reported for efficient, enantioselective production of key intermediates for the common chiral side chain of statin-type cholesterol-lowering…”
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Expanding the Scope of Asymmetric Electrophilic Atom-Transfer Reactions: Titanium- and Ruthenium-Catalyzed Hydroxylation of β-Ketoesters by Toullec, Patrick Y., Bonaccorsi, Cristina, Mezzetti, Antonio, Togni, Antonio, Trost, Barry M.

“…The enantioselective formation of a quaternary stereogenic center coinciding with a hydroxylation process is a very rare reaction from a homogeneous catalysis…”
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Copper-Catalyzed Asymmetric Conjugate Addition of Grignard Reagents to Cyclic Enones by Feringa, Ben L., Badorrey, Ramón, Peña, Diego, Harutyunyan, Syuzanna R., Minnaard, Adriaan J., Halpern, Jack

“…It is no longer necessary to use dialkylzinc reagents to obtain enantioselectivities >95% in the copper-catalyzed asymmetric conjugate addition of…”
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Chiral Biphenyl Diphosphines for Asymmetric Catalysis: Stereoelectronic Design and Industrial Perspectives by Jeulin, Séverine, de Paule, Sébastien Duprat, Ratovelomanana-Vidal, Virginie, Genêt, Jean-Pierre, Champion, Nicolas, Dellis, Philippe, Trost, Barry M.

“…Two original chiral diphosphines, SYNPHOS and DIFLUORPHOS, have been synthesized on multigram scales. Their steric and electronic profiles have been…”
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Computational Predictions of Stereochemistry in Asymmetric Thiazolium- and Triazolium-Catalyzed Benzoin Condensations by Dudding, Travis, Houk, Kendall N., Trost, Barry M.

“…The catalytic asymmetric thiazolium- and triazolium-catalyzed benzoin condensations of aldehydes and ketones were studied with computational methods…”
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Remarkably Diastereoselective Synthesis of a Chiral Biphenyl Diphosphine Ligand and Its Application in Asymmetric Hydrogenation by Qiu, Liqin, Wu, Jing, Chan, Shusun, Terry T.-L. Au-Yeung, Ji, Jian-Xin, Guo, Rongwei, Pai, Cheng-Chao, Zhou, Zhongyuan, Li, Xingshu, Fan, Qing-Hua, Albert S. C. Chan, Halpern, Jack

“…Essentially complete atropdiastereoselectivity was realized in the preparation of biaryl diphosphine dioxide by asymmetric intramolecular Ullmann coupling and…”
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Copper-Catalyzed Asymmetric Conjugate Reduction as a Route to Novel β-Azaheterocyclic Acid Derivatives by Rainka, Matthew P., Aye, Yimon, Buchwald, Stephen L., Halpern, Jack

“…A chiral copper-hydride catalyst for the asymmetric conjugate reduction of α,β-unsaturated carbonyl compounds has been used for the reduction of substrates…”
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An Efficient and General Route to Reduced Polypropionates via Zr-Catalyzed Asymmetric C-C Bond Formation by Negishi, Ei-ichi, Tan, Ze, Liang, Bo, Novak, Tibor, Trost, Barry M.

“…An efficient and general method for the synthesis of reduced polypropionates has been developed through the application of asymmetric carboalumination of…”
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Zr[bis(salicylidene)ethylenediaminato]-Mediated Baeyer-Villiger Oxidation: Stereospecific Synthesis of Abnormal and Normal Lactones by Watanabe, Akira, Uchida, Tatsuya, Irie, Ryo, Katsuki, Tsutomu, Trost, Barry M.

“…Baeyer-Villiger oxidation of racemic bicyclic cyclobutanones with Zr[bis(salicylidene)ethylenediaminato] (salen) complex 1 as catalyst in the presence of a…”
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Mo-Catalyzed Asymmetric Olefin Metathesis in Target-Oriented Synthesis: Enantioselective Synthesis of (+)-Africanol by Weatherhead, Gabriel S., Cortez, G. A., Schrock, Richard R., Hoveyda, Amir H., Halpern, Jack

“…Catalytic asymmetric ring-opening metathesis (AROM) provides an efficient method for the synthesis of a variety of optically enriched small organic molecules…”
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Infrared Spectroscopic Investigations on the Metallation of Terminal Alkynes by Zn( OTf)2 by Fässler, Roger, Tomooka, Craig S., Frantz, Doug E., Carreira, Erick M., Halpern, Jack

“…An IR study of terminal acetylenes and Zn( OTf)2 in the presence of amine bases provides evidence that is consistent with the generation of Zn-acetylides…”
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One-Pot Synthesis of Enantiopure syn-1,3-Diacetates from Racemic syn/anti Mixtures of 1,3-Diols by Dynamic Kinetic Asymmetric Transformation by Edin, Michaela, Steinreiber, Johannes, Jan-E. Bäckvall, Trost, Barry M.

“…A one-pot synthesis of enantiomerically pure syn-1,3-diacetates starting from readily accessible racemic diastereomeric mixtures of 1,3-diols has been realized…”
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Asymmetric Autocatalysis: Novel Structures, Novel Mechanism? by Gridnev, Ilya D., Brown, John M., Halpern, Jack

“…The amplifying asymmetric autocatalysis discovered by Soai and coworkers in 1995 does not fit easily into the extensively investigated framework of organozinc…”
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Editing the Stereochemical Elements in an Iridium Catalyst for Enantioselective Allylic Amination by Leitner, Andreas, Shu, Chutian, Hartwig, John F., Halpern, Jack

“…Individual diastereomeric phosphoramidites and mixtures of diastereomeric phosphoramidites were evaluated in the iridium-catalyzed amination of allylic…”
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