Search Results - "Asumda, Faizal"

Age-associated changes in the ecological niche: implications for mesenchymal stem cell aging by Asumda, Faizal Z

“…Adult stem cells are critical for organ-specific regeneration and self-renewal with advancing age. The prospect of being able to reverse tissue-specific…”
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Differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules by Asumda, Faizal Z., Hatzistergos, Konstantinos E., Dykxhoorn, Derek M., Jakubski, Silvia, Edwards, Jasmine, Thomas, Emmanuel, Schiff, Eugene R.

“…A variety of approaches have been developed for the derivation of hepatocyte-like cells from pluripotent stem cells. Currently, most of these strategies employ…”
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Update on Clinically Relevant Genetic Testing in Pediatric Dermatology by Boyd, Kevin P., Asumda, Faizal Z., Hand, Jennifer L.

“…Clinical genetic testing enables the detection of specific gene mutations and variants that predispose individuals and their family members to disease. In…”
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Nuclear cardiac troponin and tropomyosin are expressed early in cardiac differentiation of rat mesenchymal stem cells by Asumda, Faizal Z., Chase, P. Bryant

“…Nuclear actin — which is immunologically distinct from cytoplasmic actin — has been documented in a number of differentiated cell types, and cardiac isoforms…”
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Sulfatase-2 Regulates Liver Fibrosis through the TGF-β Signaling Pathway by Nakamura, Ikuo, Asumda, Faizal Z., Moser, Catherine D., Kang, Yoo Na N., Lai, Jin-Ping, Roberts, Lewis R.

“…Transforming growth factor-β (TGF-β) activates hepatic stellate cells (HSCs), which drive liver fibrosis via the production and deposition of extracellular…”
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A novel case of homozygous PAX1 mutation associated with hypoparathyroidism by Hamel, Benjamin L., Kumar, Seema, Heidenreich, Leah, Joshi, Avni, DaSilva, Christiana, Asumda, Faizal Z.

“…The PAX1 gene plays an important role in the development of the parathyroid glands and the thymus. Mouse knockout models of PAX1, PAX3, and PAX9 have been…”
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Knockout of sulfatase 2 is associated with decreased steatohepatitis and fibrosis in a mouse model of nonalcoholic fatty liver disease by Kim, Tae Hyo, Banini, Bubu A, Asumda, Faizal Z, Campbell, Nellie A, Hu, Chunling, Moser, Catherine D, Shire, Abdirashid M, Han, Shaoshan, Ma, Chenchao, Krishnan, Anuradha, Mounajjed, Taofic, White, Thomas A, Gores, Gregory J, LeBrasseur, Nathan K, Charlton, Michael R, Roberts, Lewis Rowland

“…Sulfatase 2 (SULF2) is a heparan sulfate editing enzyme that regulates the milieu of growth factors and cytokines involved in a variety of cellular processes…”
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Identification of AFG3L2 dominant optic atrophy following reanalysis of clinical exome sequencing by Brodsky, Michael C., Olson, Rory J., Asumda, Faizal Z., Lopour, Madeline Q.R., Schimmenti, Lisa A., Klee, Eric W.

“…To highlight the importance of the utility of clinical exome sequencing, and show how it led to the diagnosis of nonsyndromic autosomal dominant optic atrophy…”
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Combined Antitumor Effect of the Serine Protease Urokinase Inhibitor Upamostat and the Sphingosine Kinase 2 Inhibitor Opaganib on Cholangiocarcinoma Patient-Derived Xenografts by Asumda, Faizal Z, Campbell, Nellie A, Hassan, Mohamed A, Fathi, Reza, Vasquez Rico, Daniella F, Kiem, Melanie, Vang, Ethan V, Kim, Yo Han, Luo, Xin, O'Brien, Daniel R, Buhrow, Sarah A, Reid, Joel M, Moore, Michael J, Ben-Yair, Vered Katz, Levitt, Mark L, Leiting, Jennifer L, Abdelrahman, Amro M, Zhu, Xinli, Lucien, Fabrice, Truty, Mark J, Roberts, Lewis R

“…Upamostat is an orally available small-molecule serine protease inhibitor that is a highly potent inhibitor of trypsin 1, trypsin 2, trypsin 3 (PRSS1/2/3), and…”
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Left-sided valvular heart disease and retinopathy in a 38-year-old woman with attenuated mucopolysaccharidosis: a case report by Asumda, Faizal Z., Kraker, Jessica A., Thomas, Sarah C., Maleszewski, Joseph, Stone, Edwin M., Lanpher, Brendan C., Schimmenti, Lisa A.

“…Mucopolysaccharidoses (MPS) are a group of inherited lysosomal storage disorders caused by deficient levels and/or activity of glycosaminoglycan…”
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Age-related changes in rat bone-marrow mesenchymal stem cell plasticity by Asumda, Faizal Z, Chase, P Bryant

“…The efficacy of adult stem cells is known to be compromised as a function of age. This therefore raises questions about the effectiveness of autologous cell…”
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Abstract 3078: Effects of upamostat and opaganib on cholangiocarcinoma patient derived xenografts by Asumda, Faizal Z., Hassan, Mohamed A., Kim, Yo Han, Campbell, Nellie A., Luo, Xin, O'Brien, Daniel R., Buhrow, Sarah A., Reid, Joel M., Moore, Michael J., Ben-Yair, Vered Katz, Fathi, Reza, Levitt, Mark L., Lucien-Matteoni, Fabrice, Leiting, Jennifer L., Truty, Mark J., Roberts, Lewis R.

“…Abstract Background: Upamostat is an orally available small molecule serine protease inhibitor that is a highly potent inhibitor of trypsin 1, trypsin 2 and…”
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Minority youth access to tobacco: A neighborhood analysis of underage tobacco sales by Asumda, Faizal, Jordan, Lisa

“…The geographic and racial-ethnic inequities in health in the US are concerning, and their reduction is a priority for the national health initiative: Health…”
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The extracellular sulfatase SULF2 promotes liver tumorigenesis by stimulating assembly of a promoter-looping GLI1-STAT3 transcriptional complex by Carr, Ryan M., Romecin Duran, Paola A., Tolosa, Ezequiel J., Ma, Chenchao, Oseini, Abdul M., Moser, Catherine D., Banini, Bubu A., Huang, Jianbo, Asumda, Faizal, Dhanasekaran, Renumathy, Graham, Rondell P., Toruner, Merih D., Safgren, Stephanie L., Almada, Luciana L., Wang, Shaoqing, Patnaik, Mrinal M., Roberts, Lewis R., Fernandez-Zapico, Martin E.

“…The expression of the extracellular sulfatase SULF2 has been associated with increased hepatocellular carcinoma (HCC) growth and poor patient survival…”
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Nuclear cardiac troponins, tropomyosin and actin in native ventricular cardiomyocytes by Asumda, Faizal Z

“…Changes in gene expression determine cellular differentiation and developmental programs as cells transform from a progenitor to a mature adult state. The…”
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A novel case of homozygous PAX1 mutation associated with hypoparathyroidism by Hamel, Benjamin L, Kumar, Seema, Heidenreich, Leah, Joshi, Avni, DaSilva, Christiana, Asumda, Faizal Z

“…The PAX1 gene plays an important role in the development of the parathyroid glands and the thymus. Mouse knockout models of PAX1, PAX3, and PAX9 have been…”
Get full text

Identification of AFG3L2 dominant optic atrophy following reanalysis of clinical exome sequencing by Brodsky, Michael C, Olson, Rory J, Asumda, Faizal Z, Lopour, Madeline Q R, Schimmenti, Lisa A, Klee, Eric W

“…PurposeTo highlight the importance of the utility of clinical exome sequencing, and show how it led to the diagnosis of nonsyndromic autosomal dominant optic…”
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Left-sided valvular heart disease and retinopathy in a 38-year-old woman with attenuated mucopolysaccharidosis: a case report by Asumda, Faizal Z, Kraker, Jessica A, Thomas, Sarah C, Maleszewski, Joseph, Stone, Edwin M, Lanpher, Brendan C, Schimmenti, Lisa A

Get full text

Nuclear cardiac troponins, tropomyosin and actin in native ventricular cardiomyocytes by Asumda, Faizal Z

“…Changes in gene expression determine cellular differentiation and developmental programs as cells transform from a progenitor to a mature adult state. The…”
Get full text