Search Results - "Astore, Miro"

Protein dynamics underlying allosteric regulation by Astore, Miro A., Pradhan, Akshada S., Thiede, Erik H., Hanson, Sonya M.

“…Allostery is the mechanism by which information and control are propagated in biomolecules. It regulates ligand binding, chemical reactions, and conformational…”
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Global redox proteome and phosphoproteome analysis reveals redox switch in Akt by Su, Zhiduan, Burchfield, James G., Yang, Pengyi, Humphrey, Sean J., Yang, Guang, Francis, Deanne, Yasmin, Sabina, Shin, Sung-Young, Norris, Dougall M., Kearney, Alison L., Astore, Miro A., Scavuzzo, Jonathan, Fisher-Wellman, Kelsey H., Wang, Qiao-Ping, Parker, Benjamin L., Neely, G. Gregory, Vafaee, Fatemeh, Chiu, Joyce, Yeo, Reichelle, Hogg, Philip J., Fazakerley, Daniel J., Nguyen, Lan K., Kuyucak, Serdar, James, David E.

“…Protein oxidation sits at the intersection of multiple signalling pathways, yet the magnitude and extent of crosstalk between oxidation and other…”
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Mitochondrial electron transport chain, ceramide, and coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle by Diaz-Vegas, Alexis, Madsen, Søren, Cooke, Kristen C, Carroll, Luke, Khor, Jasmine X Y, Turner, Nigel, Lim, Xin Y, Astore, Miro A, Morris, Jonathan C, Don, Anthony S, Garfield, Amanda, Zarini, Simona, Zemski Berry, Karin A, Ryan, Andrew P, Bergman, Bryan C, Brozinick, Joseph T, James, David E, Burchfield, James G

“…Insulin resistance (IR) is a complex metabolic disorder that underlies several human diseases, including type 2 diabetes and cardiovascular disease. Despite…”
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Molecular Dynamics and Theratyping in Airway and Gut Organoids Reveal R352Q-CFTR Conductance Defect by Wong, Sharon L, Awatade, Nikhil T, Astore, Miro A, Allan, Katelin M, Carnell, Michael J, Slapetova, Iveta, Chen, Po-Chia, Setiadi, Jeffry, Pandzic, Elvis, Fawcett, Laura K, Widger, John R, Whan, Renee M, Griffith, Renate, Ooi, Chee Y, Kuyucak, Serdar, Jaffe, Adam, Waters, Shafagh A

“…A significant challenge to making targeted CFTR modulator therapies accessible to all individuals with cystic fibrosis (CF) are many mutations in the CFTR gene…”
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S945L-CFTR molecular dynamics, functional characterization and tezacaftor/ivacaftor efficacy in vivo and in vitro in matched pediatric patient-derived cell models by Allan, Katelin M., Astore, Miro A., Fawcett, Laura K., Wong, Sharon L., Chen, Po-Chia, Griffith, Renate, Jaffe, Adam, Kuyucak, Serdar, Waters, Shafagh A.

“…Cystic Fibrosis (CF) results from over 400 different disease-causing mutations in the CF Transmembrane Conductance Regulator ( CFTR ) gene. These CFTR…”
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Molecular dynamics and functional characterization of I37R-CFTR lasso mutation provide insights into channel gating activity by Wong, Sharon L., Awatade, Nikhil T., Astore, Miro A., Allan, Katelin M., Carnell, Michael J., Slapetova, Iveta, Chen, Po-chia, Capraro, Alexander, Fawcett, Laura K., Whan, Renee M., Griffith, Renate, Ooi, Chee Y., Kuyucak, Serdar, Jaffe, Adam, Waters, Shafagh A.

“…Characterization of I37R, a mutation located in the lasso motif of the CFTR chloride channel, was conducted by theratyping several CFTR modulators from both…”
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Q1291H-CFTR molecular dynamics simulations and ex vivo theratyping in nasal epithelial models and clinical response to elexacaftor/tezacaftor/ivacaftor in a Q1291H/F508del patient by Allan, Katelin M, Astore, Miro A, Kardia, Egi, Wong, Sharon L, Fawcett, Laura K, Bell, Jessica L, Visser, Simone, Chen, Po-Chia, Griffith, Renate, Jaffe, Adam, Sivam, Sheila, Vittorio, Orazio, Kuyucak, Serdar, Waters, Shafagh A

“…Cystic fibrosis (CF) is caused by a wide spectrum of mutations in the CF transmembrane conductance regulator ( ) gene, with some leading to non-classical…”
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Computer modelling the root cause of cystic fibrosis by Astore, Miro A., Chen, Po-Chia, Waters, Shafagh, Kuyucak, Serdar

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Molecular Dynamics to Explain the Pathogenesis of Gating Class Cystic Fibrosis Mutations by Astore, Miro A., Chen, Po-Chia, Waters, Shafagh, Kuyucak, Serdar

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Mitochondrial electron transport chain, ceramide, and coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle by Diaz-Vegas, Alexis, Madsen, Søren, Cooke, Kristen C, Carroll, Luke, Khor, Jasmine XY, Turner, Nigel, Lim, Xin Y, Astore, Miro A, Morris, Jonathan C, Don, Anthony S, Garfield, Amanda, Zarini, Simona, Zemski Berry, Karin A, Ryan, Andrew P, Bergman, Bryan C, Brozinick, Joseph T, James, David E, Burchfield, James G

“…Insulin resistance (IR) is a complex metabolic disorder that underlies several human diseases, including type 2 diabetes and cardiovascular disease. Despite…”
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CryoBench: Diverse and challenging datasets for the heterogeneity problem in cryo-EM by Jeon, Minkyu, Raghu, Rishwanth, Astore, Miro, Woollard, Geoffrey, Feathers, Ryan, Kaz, Alkin, Hanson, Sonya M, Cossio, Pilar, Zhong, Ellen D

“…Cryo-electron microscopy (cryo-EM) is a powerful technique for determining high-resolution 3D biomolecular structures from imaging data. As this technique can…”
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