Search Results - "Aston, K. I."

Disease gene discovery in male infertility: past, present and future by Xavier, M. J., Salas-Huetos, A., Oud, M. S., Aston, K. I., Veltman, J. A.

“…Identifying the genes causing male infertility is important to increase our biological understanding as well as the diagnostic yield and clinical relevance of…”
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Cigarette smoking significantly alters sperm DNA methylation patterns by Jenkins, T. G., James, E. R., Alonso, D. F., Hoidal, J. R., Murphy, P. J., Hotaling, J. M., Cairns, B. R., Carrell, D. T., Aston, K. I.

“…Summary Numerous health consequences of tobacco smoke exposure have been characterized, and the effects of smoking on traditional measures of male fertility…”
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“omics” of human male infertility: integrating big data in a systems biology approach by Carrell, D. T, Aston, K. I, Oliva, R, Emery, B. R, De Jonge, C. J

“…Spermatogenesis is a complex process in which >2300 genes are temporally and spatially regulated to form a terminally differentiated sperm cell that must…”
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Monozygotic twinning associated with assisted reproductive technologies: a review by Aston, K I, Peterson, C M, Carrell, D T

“…Twin birth rates have increased markedly in developed countries since the 1970s for two primary reasons: increasing maternal age and the advent and increasing…”
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Comparative analysis of three sperm DNA damage assays and sperm nuclear protein content in couples undergoing assisted reproduction treatment by Simon, L., Liu, L., Murphy, K., Ge, S., Hotaling, J., Aston, K.I., Emery, B., Carrell, D.T.

“…STUDY QUESTION Is there an association between sperm DNA damage, measured by three different assays, sperm nuclear protein content and clinical outcomes in…”
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Sperm DNA damage output parameters measured by the alkaline Comet assay and their importance by Simon, L., Aston, K. I., Emery, B. R., Hotaling, J., Carrell, D. T.

“…Summary The alkaline Comet assay has shown high diagnostic value to determine male reproductive health and prognostic ability to predict ART success. Here,…”
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Paternal influence of sperm DNA integrity on early embryonic development by Simon, L., Murphy, K., Shamsi, M.B., Liu, L., Emery, B., Aston, K.I., Hotaling, J., Carrell, D.T.

“…STUDY QUESTION Does sperm DNA damage affect early embryonic development? SUMMARY ANSWER Increased sperm DNA damage adversely affects embryo quality starting at…”
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Genetic susceptibility to male infertility: news from genome‐wide association studies by Aston, K. I.

“…Summary A thorough understanding of the genetic basis of male infertility has eluded researchers in spite of significant efforts to identify novel genetic…”
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The role of miRNAs in male human reproduction: a systematic review by Salas‐Huetos, A., James, E. R., Aston, K. I., Carrell, D. T., Jenkins, T. G., Yeste, M.

“…Background The presence of miRNAs in human reproductive tissue is intriguing and suggests the possibility that these important regulatory molecules play a role…”
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Effect of the time interval between fusion and activation on nuclear state and development in vitro and in vivo of bovine somatic cell nuclear transfer embryos by Aston, K I, Li, G P, Hicks, B A, Sessions, B R, Pate, B J, Hammon, D, Bunch, T D, White, K L

“…This study indicated that prolonged exposure of donor cell nuclei to oocyte cytoplasm before activation results in abnormal chromatin morphology, and reduced…”
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Lack of evidence for a role of PIWIL1 variants in human male infertility by Oud, M.S., Volozonoka, L., Friedrich, C., Kliesch, S., Nagirnaja, L., Gilissen, C., O’Bryan, M.K., McLachlan, R.I., Aston, K.I., Tüttelmann, F., Conrad, D.F., Veltman, J.A.

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Global gene expression analysis of bovine somatic cell nuclear transfer blastocysts and cotyledons by Aston, K.I., Li, G.P., Hicks, B.A., Sessions, B.R., Davis, A.P., Winger, Q.A., Rickords, L.F., Stevens, J.R., White, K.L.

“…Low developmental competence of bovine somatic cell nuclear transfer (SCNT) embryos is a universal problem. Abnormal placentation has been commonly reported in…”
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Divergence of sperm and leukocyte age-dependent telomere dynamics: implications for male-driven evolution of telomere length in humans by ASTON, Kenneth I, HUNT, Steven C, SUSSER, Ezra, KIMURA, Masayuki, FACTOR-LITVAK, Pam, CARRELL, Douglas, AVIV, Abraham

“…Telomere length (TL) dynamics in vivo are defined by TL and its age-dependent change, brought about by cell replication. Leukocyte TL (LTL), which reflects TL…”
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Teratozoospermia and asthenozoospermia are associated with specific epigenetic signatures by Jenkins, T. G., Aston, K. I., Hotaling, J. M., Shamsi, M. B., Simon, L., Carrell, D. T.

“…Summary Semen analysis is commonly used as a tool to assess the fertility potential of a male, despite its relatively low predictive power. In this study, we…”
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Conditioned medium increases the polyploid cell composition of bovine somatic cell nuclear-transferred blastocysts by Li, G-P, White, K L, Aston, K I, Meerdo, L N, Bunch, T D

“…The effects of bovine cumulus cell-conditioned medium on cloned bovine embryonic development and subsequent chromosome complement were examined using an…”
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Effects of amino acid substitutions in and around the arginine-glycine-aspartic acid (RGD) sequence on fertilization and parthenogenetic development in mature bovine oocytes by Sessions, B.R., Aston, K.I., Davis, A.P., Pate, B.J., White, K.L.

“…Integrins have been shown to be involved in the process of fertilization and many integrin–ligand interactions are mediated through the recognition of an…”
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The safety and efficacy of clomiphene citrate in hypoandrogenic and subfertile men by Patel, D P, Brant, W O, Myers, J B, Presson, A P, Johnstone, E B, Dorais, J A, Aston, K I, Carrell, D T, Hotaling, J M

“…Our objective was to evaluate the safety and efficacy of clomiphene citrate (CC) in infertile and hypoandrogenic men through a retrospective study between…”
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Semen parameters are unaffected by statin use in men evaluated for infertility by Keihani, S., Martin, C., Craig, J. R., Zhang, C., Presson, A. P., Myers, J. B., Aston, K. I., Emery, B. R., Carrell, D. T., Hotaling, J. M.

“…Summary The effects of statin use on conventional semen parameters in humans are largely unknown and have not been previously studied in subfertile men. We…”
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Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia by Ge, S-Q, Grifin, J, Liu, L-H, Aston, K I, Simon, L, Jenkins, T G, Emery, B R, Carrell, D T

“…Male infertility is often associated with a decreased sperm count. The Pygo2 gene is expressed in the elongating spermatid during chromatin remodeling; thus…”
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Variant PNLDC1, Defective piRNA Processing, and Azoospermia by Nagirnaja, Liina, Mørup, Nina, Nielsen, John E, Stakaitis, Rytis, Golubickaite, Ieva, Oud, Manon S, Winge, Sofia B, Carvalho, Filipa, Aston, Kenneth I, Khani, Francesca, van der Heijden, Godfried W, Marques, C. Joana, Skakkebaek, Niels E, Rajpert–De Meyts, Ewa, Schlegel, Peter N, Jørgensen, Niels, Veltman, Joris A, Lopes, Alexandra M, Conrad, Donald F, Almstrup, Kristian

“…A particular class of small noncoding RNAs are transcribed from DNA and then processed by enzymes to generate short oligonucleotides that then control gene…”
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