Search Results - "Astashkin, Andrei V."

Ligand-Centered Triplet Diradical Supported by a Binuclear Palladium(II) Dipyrrindione by Curtis, Clayton J, Astashkin, Andrei V, Conradie, Jeanet, Ghosh, Abhik, Tomat, Elisa

“…Oligopyrroles form a versatile class of redox-active ligands and electron reservoirs. Although the stabilization of radicals within oligopyrrolic π systems is…”
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Preparation of Dynamic Covalent Polymers via Inverse Vulcanization of Elemental Sulfur by Griebel, Jared J, Nguyen, Ngoc A, Astashkin, Andrei V, Glass, Richard S, Mackay, Michael E, Char, Kookheon, Pyun, Jeffrey

“…The synthesis of dynamic covalent polymers with controllable amounts of sulfur–sulfur (S–S) bonds in the polymer backbone via inverse vulcanization of…”
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Persistent, highly localized, and tunable [4]helicene radicals by Shaikh, Aslam C, Moutet, Jules, Veleta, José M, Hossain, Md Mubarak, Bloch, Jan, Astashkin, Andrei V, Gianetti, Thomas L

“…Persistent organic radicals have gained considerable attention in the fields of catalysis and materials science. In particular, helical molecules are of great…”
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Tripyrrindione as a Redox-Active Ligand: Palladium(II) Coordination in Three Redox States by Gautam, Ritika, Loughrey, Jonathan J., Astashkin, Andrei V., Shearer, Jason, Tomat, Elisa

“…The tripyrrin‐1,14‐dione scaffold of urinary pigment uroerythrin coordinates divalent palladium as a planar tridentate ligand. Spectroscopic, structural and…”
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Pulsed EPR Determination of the Distance between Heme Iron and FMN Centers in a Human Inducible Nitric Oxide Synthase by Astashkin, Andrei V, Elmore, Bradley O, Fan, Weihong, Guillemette, J. Guy, Feng, Changjian

“…Mammalian nitric oxide synthase (NOS) is a homodimeric flavo-hemoprotein that catalyzes the oxidation of l-arginine to nitric oxide (NO). Regulation of NO…”
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Macromolecular Crowding Modulates Actomyosin Kinetics by Ge, Jinghua, Bouriyaphone, Sherry D., Serebrennikova, Tamara A., Astashkin, Andrei V., Nesmelov, Yuri E.

“…Actomyosin kinetics is usually studied in dilute solutions, which do not reflect conditions in the cytoplasm. In cells, myosin and actin work in a dense…”
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Determination of the Distance between the Mo(V) and Fe(III) Heme Centers of Wild Type Human Sulfite Oxidase by Pulsed EPR Spectroscopy by Astashkin, Andrei V, Rajapakshe, Asha, Cornelison, Matthew J, Johnson-Winters, Kayunta, Enemark, John H

“…Intramolecular electron transfer (IET) between the molybdenum and heme centers of vertebrate sulfite oxidase (SO) is proposed to be a key step in the catalytic…”
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Differential calmodulin-modulatory and electron transfer properties of neuronal nitric oxide synthase mu compared to the alpha variant by Panda, Satya P., Li, Wenbing, Venkatakrishnan, Priya, Chen, Li, Astashkin, Andrei V., Masters, Bettie Sue S., Feng, Changjian, Roman, Linda J.

“…•nNOSμ contains 34 extra residues, compared to nNOSα, in a regulatory element.•nNOSμ exhibits slower electron transfer and heme nitrosyl formation, and lower…”
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Mapping the Structure of Metalloproteins with RIDME by Astashkin, Andrei V

“…Distance measurements in biological macromolecules represent a very active field of application of pulsed electron paramagnetic resonance (EPR) spectroscopy…”
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Iron Chelator Transmetalative Approach to Inhibit Human Ribonucleotide Reductase by Gaur, Kavita, Pérez Otero, Sofia C, Benjamín-Rivera, Josué A, Rodríguez, Israel, Loza-Rosas, Sergio A, Vázquez Salgado, Alexandra M, Akam, Eman A, Hernández-Matias, Liz, Sharma, Rohit K, Alicea, Nahiara, Kowaleff, Martin, Washington, Anthony V, Astashkin, Andrei V, Tomat, Elisa, Tinoco, Arthur D

“…Efforts directed at curtailing the bioavailability of intracellular iron could lead to the development of broad-spectrum anticancer drugs given the metal's…”
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Regulatory Role of Glu546 in Flavin Mononucleotide  Heme Electron Transfer in Human Inducible Nitric Oxide Synthase by Li, Wenbing, Chen, Li, Lu, Changyuan, Elmore, Bradley O, Astashkin, Andrei V, Rousseau, Denis L, Yeh, Syun-Ru, Feng, Changjian

“…Nitric oxide (NO) production by mammalian NO synthase (NOS) is believed to be regulated by the docking of the flavin mononucleotide (FMN) domain in one subunit…”
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Paramagnetism and Fluorescence of Zinc(II) Tripyrrindione: A Luminescent Radical Based on a Redox-Active Biopyrrin by Gautam, Ritika, Petritis, Steven J, Astashkin, Andrei V, Tomat, Elisa

“…The ability of bilins and other biopyrrins to form fluorescent zinc complexes has been known for more than a century; however, the exact identity of the…”
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The Gadolinium(III)−Water Hydrogen Distance in MRI Contrast Agents by Caravan, Peter, Astashkin, Andrei V, Raitsimring, Arnold M

“…The ion−nuclear distance of Gd(III) to a coordinated water proton, r Gd - H, is central to the understanding of the efficacy of gadolinium-based MRI contrast…”
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Interactions of Metal-Based and Ligand-Based Electronic Spins in Neutral Tripyrrindione π Dimers by Gautam, Ritika, Astashkin, Andrei V, Chang, Tsuhen M, Shearer, Jason, Tomat, Elisa

“…The ability of tetrapyrrolic macrocycles to stabilize unpaired electrons and engage in π–π interactions is essential for many electron-transfer processes in…”
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Positional Distributions of the Tethered Modules in Nitric Oxide Synthase: Monte Carlo Calculations and Pulsed EPR Measurements by Astashkin, Andrei V, Li, Jinghui, Zheng, Huayu, Feng, Changjian

“…The nitric oxide synthase (NOS) enzyme consists of multiple domains connected by flexible random coil tethers. In a catalytic cycle, the NOS domains move…”
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Analyzing the FMN—heme interdomain docking interactions in neuronal and inducible NOS isoforms by pulsed EPR experiments and conformational distribution modeling by Astashkin, Andrei V., Gyawali, Yadav Prasad, Jiang, Ting, Zhang, Haikun, Feng, Changjian

“…Nitric oxide synthases (NOSs), a family of flavo-hemoproteins with relatively rigid domains linked by flexible regions, require optimal FMN domain docking to…”
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Solving Kinetic Equations for the Laser Flash Photolysis Experiment on Nitric Oxide Synthases: Effect of Conformational Dynamics on the Interdomain Electron Transfer by Astashkin, Andrei V, Feng, Changjian

“…The production of nitric oxide by the nitric oxide synthase (NOS) enzyme depends on the interdomain electron transfer (IET) between the flavin mononucleotide…”
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A docked state conformational dynamics model to explain the ionic strength dependence of FMN – heme electron transfer in nitric oxide synthase by Astashkin, Andrei V., Li, Jinghui, Zheng, Huayu, Miao, Yubin, Feng, Changjian

“…The FMN−heme interdomain electron transfer (IET) in nitric oxide synthase (NOS) is a key stage of the electron transport chain, which supplies the catalytic…”
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A Homodimer of Withaferin A Formed by Base-Promoted Elimination of Acetic Acid from 27‑O‑Acetylwithaferin A Followed by a Diels–Alder Reaction by Wijeratne, E. M. Kithsiri, Xu, Ya-Ming, Padumadasa, Chayanika, Astashkin, Andrei V., Gunatilaka, A. A. Leslie

“…Treatment of 27-O-acetylwithaferin A (2) with the non-nucleophilic base, 1,8-diazabicyclo­[5,4,0]­undec-7-ene (DBU), afforded…”
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De Novo Design of an Artificial Bis[4Fe-4S] Binding Protein by Roy, Anindya, Sarrou, Iosifina, Vaughn, Michael D, Astashkin, Andrei V, Ghirlanda, Giovanna

“…In nature, protein subunits containing multiple iron–sulfur clusters often mediate the delivery of reducing equivalents from metabolic pathways to the active…”
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