Reactogenic properties and immunogenicity of measles and mumps vaccines when used by different procedures

In the controlled epidemiological trial the reactogenic and immunogenic properties of live measles vaccine (LMV) and live parotitis vaccine (LPV) were evaluated in identical groups of children immunized in accordance with different schedules: only LMV or LPV, the injection of these preparations mixe...

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Bibliographic Details
Published in:	Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 6; p. 9
Main Authors:	Astabatsian, M A, Bolotovskiĭ, V M, Gelikman, B G, Mikheeva, I V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-06-1986
Subjects:	Antibodies, Viral - analysis Antibody Specificity Body Temperature - drug effects Humans Immunization - methods Infant Measles Vaccine - administration & dosage Measles Vaccine - adverse effects Measles Vaccine - immunology Measles virus - immunology Mumps Vaccine - administration & dosage Mumps Vaccine - adverse effects Mumps Vaccine - immunology Mumps virus - immunology Time Factors
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Summary:	In the controlled epidemiological trial the reactogenic and immunogenic properties of live measles vaccine (LMV) and live parotitis vaccine (LPV) were evaluated in identical groups of children immunized in accordance with different schedules: only LMV or LPV, the injection of these preparations mixed in one syringe or with the use of separate syringes, or at an interval of 3 months. The highest number of febrile reactions, rash and catarrhal symptoms was registered among children immunized with LMV, and the lowest number of such reactions in the groups of children immunized with LPV. The injection of LMV and LPV with one syringe or simultaneously with separate syringes decreased the intensity of immune response to the injection of the antigens. Immunization against measles and parotitis by the injection of monopreparations at an interval of 3 months is believed to be most expedient.
ISSN:	0372-9311