Search Results - "Assunção, Nilson A"
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1H qNMR-Based Metabolomics Discrimination of Covid-19 Severity
Published in Journal of proteome research (01-07-2022)“…The coronavirus disease 2019 (Covid-19), which caused respiratory problems in many patients worldwide, led to more than 5 million deaths by the end of 2021…”
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2
Methylmalonate impairs mitochondrial respiration supported by NADH-linked substrates: Involvement of mitochondrial glutamate metabolism
Published in Journal of neuroscience research (01-06-2012)“…The neurodegeneration that occurs in methylmalonic acidemia is proposed to be associated with impairment of mitochondrial oxidative metabolism resulting from…”
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3
Multiplatform Metabolomics: Enhancing the Severity Risk Prognosis of SARS-CoV‑2 Infection
Published in ACS omega (19-11-2024)“…Concerns about the SARS-CoV-2 outbreak (COVID-19) continue to persist even years later, with the emergence of new variants and the risk of disease severity…”
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4
Generation of Singlet Oxygen by the Glyoxal–Peroxynitrite System
Published in Journal of the American Chemical Society (28-12-2011)“…Diacetyl, methylglyoxal, and glyoxal are α-dicarbonyl catabolites prone to nucleophilic additions of amino groups of proteins and nucleobases, thereby…”
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5
Cri-du-Chat Syndrome: Revealing a Familial Atypical Deletion in 5p
Published in Molecular syndromology (01-01-2023)“…Introduction: Cri-du-chat syndrome is generally diagnosed when patients present a high-pitched cry at birth, microcephaly, ocular hypertelorism, and prominent…”
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6
The dual face of endogenous α-aminoketones: Pro-oxidizing metabolic weapons
Published in Comparative biochemistry and physiology. Toxicology & pharmacology (01-07-2007)“…Amino metabolites with potential prooxidant properties, particularly α-aminocarbonyls, are the focus of this review. Among them we emphasize 5-aminolevulinic…”
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Pharmacokinetic and clinical effects of two bupivacaine concentrations on axillary brachial plexus block
Published in Brazilian journal of anesthesiology (Elsevier) (01-03-2018)“…The risk of systemic bupivacaine toxicity is a persistent problem, which makes its pharmacokinetic study fundamental for regional anesthesia safety. There is…”
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8
L-Arginine Transport and Nitric Oxide Production in Kinin Receptor B1-/- Endothelial Cells
Published in Protein and peptide letters (01-01-2015)“…Kinins are important vasoactive peptides, but the role of the B1 receptor subtype in the vascular control is poorly understood. This study analyzed the nitric…”
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9
Radical Acetylation of 2′-Deoxyguanosine and l-Histidine Coupled to the Reaction of Diacetyl with Peroxynitrite in Aerated Medium
Published in Chemical research in toxicology (01-04-2008)“…Diacetyl, like other α-dicarbonyl compounds, is reportedly cytotoxic and genotoxic. A food and cigarette contaminant, it is related with alcohol hepatotoxicity…”
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10
1 H qNMR-Based Metabolomics Discrimination of Covid-19 Severity
Published in Journal of proteome research (01-07-2022)“…The coronavirus disease 2019 (Covid-19), which caused respiratory problems in many patients worldwide, led to more than 5 million deaths by the end of 2021…”
Get full text
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11
Increased chemical acetylation of peptides and proteins in rats after daily ingestion of diacetyl analyzed by Nano-LC-MS/MS
Published in PeerJ (San Francisco, CA) (25-04-2018)“…Acetylation alters several protein properties including molecular weight, stability, enzymatic activity, protein-protein interactions, and other biological…”
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12
Further studies on peptide synthesis at high temperature
Published in Advances in experimental medicine and biology (2009)Get more information
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13
Nonaqueous capillary electrophoresis in coated capillaries: An interesting alternative for proteomic applications
Published in Electrophoresis (01-09-2005)“…This work brings together some contributions for the use of nonaqueous media for proteomic analysis, for both capillary electrophoresis (CE) separation and the…”
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14
Morpho/Proteomic Comparative between High Grade Pleomorphic Sarcoma and Metastasis Diagnosed in an Old Captive Common Hippo
Published in Journal of the Brazilian Chemical Society (01-02-2018)“…Old age is a risk factor for cancer development in humans and animals, and studies have shown that tumors in animals are acceptable models for studying human…”
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15
Microwave-assisted solid-phase peptide synthesis at 60 °C: alternative conditions with low enantiomerization
Published in Journal of peptide science (01-12-2009)“…Several conditions have been used in the coupling reaction of stepwise SPPS at elevated temperature (SPPS‐ET), but we have elected the following as our first…”
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16
Bioanalytical Studies of Porphyric Disorders Using HPLC with Fluorescence Detection
Published in Journal of the Brazilian Chemical Society (01-10-2014)“…We describe here the development, validation, quantification and application of a method for determination of heme porphyrin precursors in the urine of…”
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17
Development of nanoinjector devices for electrospray ionization - tandem mass spectrometry (ESI-MSn)
Published in Journal of the Brazilian Chemical Society (01-09-2012)“…In mass spectrometric (MS) systems with electrospray ionization (ESI), the sample can be analyzed coupled to separation systems (such as liquid chromatography…”
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18
Potential Diagnostic Assay for Cystinuria by Capillary Electrophoresis Coupled to Mass Spectrometry
Published in Journal of the Brazilian Chemical Society (01-04-2013)“…Cystinuria is an autosomal recessive genetic disorder characterized by abnormal intestinal and renal tubular transport of L-cystine as well as of L-lysine,…”
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19
Electrospray Ionization Mass Spectrometry Applied to Study the Radical Acetylation of Amino Acids, Peptides and Proteins
Published in Journal of the Brazilian Chemical Society (01-12-2013)“…Recently, our group proposed a process that generated acetyl radicals in a reaction medium buffered with a diacetyl/peroxynitrite system. Diacetyl is a…”
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20
Direct determination of plant-growth related metabolites by capillary electrophoresis with spectrophotometric UV detection
Published in Journal of the Brazilian Chemical Society (2009)“…The detection of plant hormones and growth regulators is of great interest for many biological studies especially in the determination of metabolites related…”
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