Search Results - "Assoian, R K"

Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways by Schwartz, M A, Assoian, R K

“…Cell cycle progression in mammalian cells is strictly regulated by both integrin-mediated adhesion to the extracellular matrix and by binding of growth factors…”
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Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation by Zhu, X, Assoian, R K

“…Adhesion to extracellular matrix mediates cell cycle progression in mid-late G1; this effect involves an integrin-dependent organization of the cytoskeleton…”
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Adhesion-Dependent Cell Cycle Progression Linked to the Expression of Cyclin D1, Activation of Cyclin E-cdk2, and Phosphorylation of the Retinoblastoma Protein by Zhu, Xiaoyun, Ohtsubo, Motoaki, Böhmer, Ralph M., Roberts, James M., Assoian, Richard K.

“…Growth factors and cell anchorage jointly regulate transit through G1 in almost all cell types, but the cell cycle basis for this combined requirement remains…”
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Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1 by Böhmer, R M, Scharf, E, Assoian, R K

“…The proliferation of many nontransformed cells depends on cell adhesion. We report here that disrupting the cytoskeleton in normal human fibroblasts causes the…”
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Expression and Secretion of Type β Transforming Growth Factor by Activated Human Macrophages by Assoian, Richard K., Fleurdelys, Barbara E., Stevenson, Henry C., Miller, Paul J., Madtes, David K., Raines, Elaine W., Ross, Russell, Sporn, Michael B.

“…Alveolar macrophages activated with concanavalin A and peripheral blood monocytes activated with lipopolysaccharide secrete type β transforming growth factor…”
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A Link Between Cyclin A Expression and Adhesion-Dependent Cell Cycle Progression by Guadagno, Thomas M., Ohtsubo, Motoaki, Roberts, James M., Assoian, Richard K.

“…Cell adhesion has an essential role in regulating proliferation during the G$_1$ phase of the cell cycle, and loss of this adhesion requirement is a classic…”
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Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro by Roberts, A.B, Sporn, M.B, Assoian, R.K, Smith, J.M, Roche, N.S, Wakefield, L.M, Heine, U.I, Liotta, L.A, Falanga, V, Kehrl, J.H

“…Transforming growth factor type β (TGF-β ), when injected subcutaneously in newborn mice, causes formation of granulation tissue (induction of angiogenesis and…”
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Type β Transforming Growth Factor in Human Platelets: Release during Platelet Degranulation and Action on Vascular Smooth Muscle Cells by Assoian, Richard K., Sporn, Michael B.

“…A specific radioimmunoassay for type beta transforming growth factor (TGF-β) was developed and used to show that human platelets treated with thrombin release…”
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Integrating the MAP kinase signal into the G1 phase cell cycle machinery by Roovers, Kristin, Assoian, Richard K.

“…Growth factors and the extracellular matrix provide the environmental cues that control the proliferation of most cell types. The binding of growth factors and…”
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The extracellular matrix as a cell cycle control element in atherosclerosis and restenosis by Assoian, R K, Marcantonio, E E

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Differentiation-Enhanced Binding of the Amino-Terminal Fragment of Human Urokinase Plasminogen Activator to a Specific Receptor on U937 Monocytes by Stoppelli, M. Patrizia, Corti, Angelo, Soffientini, Adolfo, Cassani, Giovanni, Blasi, Francesco, Assoian, Richard K.

“…The purified amino-terminal fragment (ATF) of human urokinase plasminogen activator (residues 1-135), which is not required for activation of plasminogen,…”
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Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization by Assoian, R K, Komoriya, A, Meyers, C A, Miller, D M, Sporn, M B

“…Acidic ethanol extracts of human platelets induced non-neoplastic normal rat kidney fibroblasts to undergo anchorage-independent growth. Less than 100 ng/ml of…”
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Biphasic effects of type beta transforming growth factor on epidermal growth factor receptors in NRK fibroblasts. Functional consequences for epidermal growth factor-stimulated mitosis by Assoian, R K

“…Exposure of confluent NRK cells to transforming growth factor-beta (TGF-beta) results in distinct alterations in subpopulations of plasma membrane epidermal…”
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Distinct Effects of Mitogens and the Actin Cytoskeleton on CREB and Pocket Protein Phosphorylation Control the Extent and Timing of Cyclin A Promoter Activity by Bottazzi, Maria Elena, Buzzai, Monica, Zhu, Xiaoyun, Desdouets, Chantal, Bréchot, Christian, Assoian, Richard K.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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G1/S Control of Anchorage-Independent Growth in the Fibroblast Cell Cycle by Guadagno, Thomas M., Assoian, Richard K.

“…We have developed methodology to identify the block to anchorage-independent growth and position it within the fibroblast cell cycle. Results with NRK…”
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Anchorage-Dependent Cell Cycle Progression by Assoian, Richard K.

“…With the explosion of information about cell cycle control in general and cyclin-dependent kinases in particular, researchers have begun to develop a molecular…”
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Induction of transforming growth factor-alpha in activated human alveolar macrophages by Madtes, D K, Raines, E W, Sakariassen, K S, Assoian, R K, Sporn, M B, Bell, G I, Ross, R

“…The early monocyte infiltration observed in normal wound repair and in a number of pathologic processes precedes the epithelial and connective tissue…”
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Timing of cyclin D1 expression within G1 phase is controlled by Rho by Welsh, Catherine F, Roovers, Kristin, Villanueva, Jessie, Liu, YunQi, Schwartz, Martin A, Assoian, Richard K

“…The expression of cyclin D1 in mid-G1 phase is associated with sustained ERK activity, and we show here that Rho is required for the sustained ERK signal…”
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The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation by Cuff, C A, Kothapalli, D, Azonobi, I, Chun, S, Zhang, Y, Belkin, R, Yeh, C, Secreto, A, Assoian, R K, Rader, D J, Puré, E

“…Atherosclerosis causes most acute coronary syndromes and strokes. The pathogenesis of atherosclerosis includes recruitment of inflammatory cells to the vessel…”
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Integrin-Mediated Adhesion Regulates ERK Nuclear Translocation and Phosphorylation of Elk-1 by Aplin, Andrew E., Stewart, Sheryl A., Assoian, Richard K., Juliano, R. L.

“…Integrin-mediated adhesion to the extracellular matrix permits efficient growth factor-mediated activation of extracellular signal-regulated kinases (ERKs)…”
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