Immunogenicity of rabies virus inactivated by beta-propiolactone, acetylethyleneimine, and ionizing irradiation

Ionizing radiation, β-propiolactone, and acetylethyleneimine were compared for their ability as virus-inactivating agents for the preparation of rabies vaccine. Each agent reduced viral infectivity exponentially; ionizing radiation also destroyed viral hemagglutinin. The vaccine prepared by ionizing...

Full description

Saved in:

Bibliographic Details
Published in:	Applied microbiology Vol. 23; no. 5; pp. 914 - 918
Main Authors:	Wiktor, T.J, Asslestad, H.G, Kaplan, M.M
Format:	Journal Article
Language:	English
Published:	01-01-1972
Subjects:	animal diseases animal health Clinical Microbiology, Virology, and Immunology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Ionizing radiation, β-propiolactone, and acetylethyleneimine were compared for their ability as virus-inactivating agents for the preparation of rabies vaccine. Each agent reduced viral infectivity exponentially; ionizing radiation also destroyed viral hemagglutinin. The vaccine prepared by ionizing radiation was equal or superior to that prepared by β-propiolactone in its ability to protect mice from rabies infection. The acetylethyleneimine-treated vaccine was a less potent immunogen.
Bibliography:	On leave from The World Health Organization, Geneva, Switzerland.
ISSN:	0003-6919
DOI:	10.1128/AEM.23.5.914-918.1972