Acute tubulointerstitial nephritis associated with infliximab therapy in a patient with Crohn’s disease: a case report

We report the case of a 39-year-old man who presented with a history of generalized fatigue, nausea, subjective fever with rigors, and renal dysfunction after receiving infliximab (IFX) therapy for Crohn’s disease. A renal biopsy revealed acute tubulointerstitial nephritis (ATIN). After other causes...

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Bibliographic Details
Published in:	CEN case reports
Main Authors:	Alghamdi, Naif, Alshehri, Fahad, Alhazza, Sultan, Bhutto, Fahad, Alhassan, Azhari, Kechrid, Mohammed, Alshehri, Dhafer, Alshammari, Kadi, Assiri, Talal, Assiri, Ohoud, Darewsh, Emad, Ali, Mohammed, Qadri, Ruba, Alahmadi, Yasser
Format:	Journal Article
Language:	English
Published:	02-11-2024
Online Access:	Get full text
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Summary:	We report the case of a 39-year-old man who presented with a history of generalized fatigue, nausea, subjective fever with rigors, and renal dysfunction after receiving infliximab (IFX) therapy for Crohn’s disease. A renal biopsy revealed acute tubulointerstitial nephritis (ATIN). After other causes of acute kidney injury were excluded, steroid therapy was initiated, his fever subsided, and kidney function improved. From this case report, infliximab could be a rare cause of elevated kidney function and that it should be not considered a completely safe treatment or disregarded as potential cause of ATIN.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2192-4449 2192-4449
DOI:	10.1007/s13730-024-00943-6