SQUAMOUS CELL CARCINOMA OF THE MAXILLARY GINGIVA, MORPHOLOGICALLY COMPATIBLE WITH CUNICULATUM VARIANT: A CASE REPORT
A 45-year-old White female patient presented a painful swelling of the left maxillary gingiva, present for about 7 months, with both periapical and periodontal involvement of the premolar region. Intraoral examination showed a granulomatous nodular lesion with a moriform aspect. Panoramic radiograph...
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| Published in: | Oral surgery, oral medicine, oral pathology and oral radiology Vol. 134; no. 3; p. e130 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier Inc
01-09-2022
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| Online Access: | Get full text |
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| Summary: | A 45-year-old White female patient presented a painful swelling of the left maxillary gingiva, present for about 7 months, with both periapical and periodontal involvement of the premolar region. Intraoral examination showed a granulomatous nodular lesion with a moriform aspect. Panoramic radiography showed an osteolytic lesion with maxillary sinus veiling, in contiguity with dental elements. Incisional biopsy was performed with clinical suspicion ranging from reactive lesion to a carcinoma. Microscopic examination revealed a malignant well-differentiated squamous epithelial proliferation, forming “rabbit burrows,” leading to the diagnosis of carcinoma cuniculatum. The patient was submitted to a left hemimaxillectomy with confirmation of carcinoma cuniculatum, and neck dissection revealed 8/61 lymph node involvement. Immunohistochemistry showed positivity for cytokeratin 5/6 and p63 protein, compatible with an invasive, keratinizing squamous cell carcinoma, moderately differentiated in 1 of the material blocks. The patient underwent adjuvant chemotherapy and radiotherapy but died 8 months after the initial diagnosis. |
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| ISSN: | 2212-4403 2212-4411 |
| DOI: | 10.1016/j.oooo.2022.01.269 |