Search Results - "Assar, Zahra"

Design, Synthesis, and Structural Characterization of Lysine Covalent BH3 Peptides Targeting Mcl‑1 by Gambini, Luca, Udompholkul, Parima, Baggio, Carlo, Muralidharan, Aruljothi, Kenjić, Nikola, Assar, Zahra, Perry, J. Jefferson P, Pellecchia, Maurizio

“…Modulating disease-relevant protein–protein interactions (PPIs) using pharmacological tools is a critical step toward the design of novel therapeutic…”
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Novel nitric oxide donors are coronary vasodilators that also bind to the papain-like protease of SARS-CoV-2 by Schmedtje, John F., Ciske, Fred, Muzzarelli, Kendall M., Assar, Zahra

“…Several investigational nitric oxide donors were originally created to correct vascular endothelial dysfunction in cardiovascular diseases. These 48 compounds…”
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Structures of holo wild-type human cellular retinol-binding protein II (hCRBPII) bound to retinol and retinal by Nossoni, Zahra, Assar, Zahra, Yapici, Ipek, Nosrati, Meisam, Wang, Wenjing, Berbasova, Tetyana, Vasileiou, Chrysoula, Borhan, Babak, Geiger, James

“…Cellular retinol‐binding proteins (CRBPs) I and II, which are members of the intracellular lipid‐binding protein (iLBP) family, are retinoid chaperones that…”
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Domain-Swapped Dimers of Intracellular Lipid-Binding Proteins: Evidence for Ordered Folding Intermediates by Assar, Zahra, Nossoni, Zahra, Wang, Wenjing, Santos, Elizabeth M., Kramer, Kevin, McCornack, Colin, Vasileiou, Chrysoula, Borhan, Babak, Geiger, James H.

“…Human Cellular Retinol Binding Protein II (hCRBPII), a member of the intracellular lipid-binding protein family, is a monomeric protein responsible for the…”
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Abstract 13295: Novel Experimental Therapeutics for COVID-19 Derived From a Nitric Oxide Donor by Schmedtje, John F, Assar, Zahra

“…Urea transport protein B, the product of the gene SLC14A1, facilitates transport of urea, water and urea analogues across cell membranes. SLC14A1 mRNA is…”
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Abstract 10067: A Nitric Oxide Donor Binds to SARS-CoV-2 Papain-Like Protease with Therapeutic Implications by Schmedtje, John F, Assar, Zahra, Ciske, Fred

“…Novel compounds developed as nitric oxide (NO) donors for cardiovascular diseases were created by linking an urea-like NO donor to the 5-carbon of the generic…”
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Covalent Targeting of Histidine Residues with Aryl Fluorosulfates: Application to Mcl-1 BH3 Mimetics by Alboreggia, Giulia, Udompholkul, Parima, Atienza, Emma L., Muzzarelli, Kendall, Assar, Zahra, Pellecchia, Maurizio

“…Covalent drugs provide pharmacodynamic and pharmacokinetic advantages over reversible agents. However, covalent strategies have been developed mostly to target…”
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Histidine-Covalent Stapled Alpha-Helical Peptides Targeting hMcl‑1 by Alboreggia, Giulia, Udompholkul, Parima, Baggio, Carlo, Muzzarelli, Kendall, Assar, Zahra, Pellecchia, Maurizio

“…Several novel and effective cysteine targeting (Cys) covalent drugs are in clinical use. However, the target area containing a druggable Cys residue is…”
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A structural explanation for the mechanism and specificity of plant branching enzymes I and IIb by Gavgani, Hadi Nayebi, Fawaz, Remie, Ehyaei, Nona, Walls, David, Pawlowski, Kathryn, Fulgos, Raoul, Park, Sunghoon, Assar, Zahra, Ghanbarpour, Alireza, Geiger, James H.

“…Branching enzymes (BEs) are essential in the biosynthesis of starch and glycogen and play critical roles in determining the fine structure of these polymers…”
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ERO1-PDI Redox Signaling in Health and Disease by Jha, Vishwanath, Kumari, Tripti, Manickam, Vijayprakash, Assar, Zahra, Olson, Kirk L, Min, Jeong-Ki, Cho, Jaehyung

“…Protein disulfide isomerase (PDI) and endoplasmic reticulum oxidoreductase 1 (ERO1) are crucial for oxidative protein folding in the endoplasmic reticulum…”
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Regulation of Absorption and Emission in a Protein/Fluorophore Complex by Santos, Elizabeth M., Chandra, Ishita, Assar, Zahra, Sheng, Wei, Ghanbarpour, Alireza, Bingham, Courtney, Vasileiou, Chrysoula, Geiger, James H., Borhan, Babak

“…Human cellular retinol binding protein II (hCRBPII) was used as a protein engineering platform to rationally regulate absorptive and emissive properties of a…”
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Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors by Holt, Melissa C, Assar, Zahra, Beheshti Zavareh, Reza, Lin, Lin, Anglin, Justin, Mashadova, Oksana, Haldar, Daniel, Mullarky, Edouard, Kremer, Daniel M, Cantley, Lewis C, Kimmelman, Alec C, Stein, Adam J, Lairson, Luke L, Lyssiotis, Costas A

“…Pancreatic cancer cells are characterized by deregulated metabolic programs that facilitate growth and resistance to oxidative stress. Among these programs,…”
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Front Cover: Human Cellular Retinol Binding Protein II Forms a Domain‐Swapped Trimer Representing a Novel Fold and a New Template for Protein Engineering (ChemBioChem 22/2020) by Ghanbarpour, Alireza, Santos, Elizabeth M., Pinger, Cody, Assar, Zahra, Hossaini Nasr, Seyedmehdi, Vasileiou, Chrysoula, Spence, Dana, Borhan, Babak, Geiger, James H.

“…The folding pathway of human cellular retinol binding protein II was manipulated to favor formation of the shown domain‐swapped trimer, by rational protein…”
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Origin of Chain Length Specificites of Starch Branching Enzyme by Nayebi Gavgani, Hadi, Fawaz, Remie, Assar, Zahra, Ghanbarpour, Alireza, Walls, David, McGovern, Sarah, Geiger, James H.

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Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety by Cohen, Frederick, Aggen, James B., Andrews, Logan D., Assar, Zahra, Boggs, Jen, Choi, Taylor, Dozzo, Paola, Easterday, Ashton N., Haglund, Cat M., Hildebrandt, Darin J., Holt, Melissa C., Joly, Kristin, Jubb, Adrian, Kamal, Zeeshan, Kane, Timothy R., Konradi, Andrei W., Krause, Kevin M., Linsell, Martin S., Machajewski, Timothy D., Miroshnikova, Olga, Moser, Heinz E., Nieto, Vincent, Phan, Thu, Plato, Craig, Serio, Alisa W., Seroogy, Julie, Shakhmin, Anton, Stein, Adam J., Sun, Alex D., Sviridov, Serguei, Wang, Zhan, Wlasichuk, Kenneth, Yang, Wen, Zhou, Xiaoming, Zhu, Hai, Cirz, Ryan T.

“…UDP‐3‐O‐(R‐3‐hydroxymyristoyl)‐N‐acetylglucosamine deacetylase (LpxC) is a Zn2+ deacetylase that is essential for the survival of most pathogenic Gram‐negative…”
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Engineering the hCRBPII Domain-Swapped Dimer into a New Class of Protein Switches by Ghanbarpour, Alireza, Pinger, Cody, Esmatpour Salmani, Rahele, Assar, Zahra, Santos, Elizabeth M, Nosrati, Meisam, Pawlowski, Kathryn, Spence, Dana, Vasileiou, Chrysoula, Jin, Xiangshu, Borhan, Babak, Geiger, James. H

“…Protein conformational switches or allosteric proteins play a key role in the regulation of many essential biological pathways. Nonetheless, the implementation…”
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Human Cellular Retinol Binding Protein II Forms a Domain‐Swapped Trimer Representing a Novel Fold and a New Template for Protein Engineering by Ghanbarpour, Alireza, Santos, Elizabeth M., Pinger, Cody, Assar, Zahra, Hossaini Nasr, Seyedmehdi, Vasileiou, Chrysoula, Spence, Dana, Borhan, Babak, Geiger, James H.

“…Domain‐swapping is a mechanism for evolving new protein structure from extant scaffolds, and has been an efficient protein‐engineering strategy for tailoring…”
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Elucidation of iLBP Family Folding Pathway and Study of Reengineering Them as Fluorescent Protein Tags via Structural Analysis by Assar, Zahra

“…The intracellular lipid binding proteins (iLBP) family are found in the cells of mammals, birds, fish, amphibians and reptiles. They function to shuttle large…”
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An iLBP Family Member Domain Swapped Dimer is Evidence for a Highly Ordered Folding Intermediate by Assar, Zahra, Nossoni, Zahra, Wang, Wenjing, Borhan, Babak, Geiger, James H.

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Domain-Swapped Dimers of Intracellular Lipid-Binding Proteins: Evidence for Ordered Folding Intermediates by Assar, Zahra, Nossoni, Zahra, Wang, Wenjing, Santos, Elizabeth M., Kramer, Kevin, McCornack, Colin, Vasileiou, Chrysoula, Borhan, Babak, Geiger, James H.

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