Tannin-mediated induction of proline-rich protein synthesis

Tannin-mediated induction of proline-rich protein synthesis

Feeding high-tannin sorghum to rats causes dramatic changes in gene expression of parotid glands similar to that induced by isoproterenol treatment. Within 3 days parotid glands enlarge about 3-fold and a series of proline-rich proteins (PRPS) increase about 12-fold. These morphological and biochemi...

Full description

Saved in:
Bibliographic Details
Published in:Journal of agricultural and food chemistry Vol. 40; no. 1; pp. 93 - 97
Main Authors: Mehansho, Haile, Asquith, Tom N, Butler, Larry G, Rogler, John C, Carlson, Don M
Format: Journal Article
Language:English
Published: Washington, DC American Chemical Society 01-01-1992
Subjects:
Biological and medical sciences
DIETA
GLANDE SALIVAIRE
GLANDULAS SALIVALES
Medical sciences
MEDICAMENT NEUROTROPE
MEDICAMENTOS NEUROTROPICOS
Plant poisons toxicology
PROLINA
PROLINE
RAT
RATA
REGIME ALIMENTAIRE
SINTESIS DE PROTEINAS
SORGHUM
SYNTHESE PROTEIQUE
TANINOS
TANNIN
Toxicology
Parotid gland
Rat
Toxicity
Rodentia
Oral administration
Proline
Gene expression
β-Adrenergic receptor
Vertebrata
Mammalia
Tannin
Protein synthesis
Animal
Plant origin
Sorghum (food)
Food
Hypertrophy
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Feeding high-tannin sorghum to rats causes dramatic changes in gene expression of parotid glands similar to that induced by isoproterenol treatment. Within 3 days parotid glands enlarge about 3-fold and a series of proline-rich proteins (PRPS) increase about 12-fold. These morphological and biochemical changes have now been demonstrated to occur in response to the ingestion of purified tannins. Addition of either dimer or polymer condensed tannins or tannic acid to diets resulted in both the hypertrophic effect and induction of PRPs. Addition of propranolol, a beta-antagonist, to the high-tannin diet blocked both the induction of PRPs and the hypertrophic effects. In vitro translations of total RNA from parotid glands showed dramatically reduced levels of PRP mRNAs indicating that propranolol may have inhibited transcription. The inhibiting effect of propranolol suggests a major role for beta-receptors in the tannin induction of PRP biosynthesis and parotid gland hypertrophy
Bibliography:9311717
L70
istex:1E9E81A24CB41B010177FAF4EA5519AF9EBB976F
ark:/67375/TPS-BQ791ZS3-3
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0021-8561
1520-5118
DOI:10.1021/jf00013a018