Search Results - "Asquith, Darren L"

MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis by Kurowska-Stolarska, Mariola, Alivernini, Stefano, Ballantine, Lucy E, Asquith, Darren L, Millar, Neal L, Gilchrist, Derek S, Reilly, James, Ierna, Michelle, Fraser, Alasdair R, Stolarski, Bartosz, McSharry, Charles, Hueber, Axel J, Baxter, Derek, Hunter, John, Gay, Steffen, Liew, Foo Y, McInnes, Iain B

“…MicroRNA (miRNA) species (miR) regulate mRNA translation and are implicated as mediators of disease pathology via coordinated regulation of molecular effector…”
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Animal models of rheumatoid arthritis by Asquith, Darren L, Miller, Ashley M, McInnes, Iain B, Liew, Foo Y

“…Animal models have been used extensively in studies of rheumatoid arthritis pathogenesis. Despite the inherent limitations of all animal models, several rodent…”
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IL-33 reduces the development of atherosclerosis by Miller, Ashley M, Xu, Damo, Asquith, Darren L, Denby, Laura, Li, Yubin, Sattar, Naveed, Baker, Andrew H, McInnes, Iain B, Liew, Foo Y

“…Atherosclerosis is a chronic inflammatory disease of the vasculature commonly leading to myocardial infarction and stroke. We show that IL-33, which is a novel…”
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Cutting Edge: Mast Cells Express IL-17A in Rheumatoid Arthritis Synovium by Hueber, Axel J, Asquith, Darren L, Miller, Ashley M, Reilly, Jim, Kerr, Shauna, Leipe, Jan, Melendez, Alirio J, McInnes, Iain B

“…Abstract The proinflammatory cytokine IL-17A is considered a crucial player in rheumatoid arthritis (RA) pathogenesis. In experimental models of autoimmune…”
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Interleukin-33 Induces Protective Effects in Adipose Tissue Inflammation During Obesity in Mice by Miller, Ashley M, Asquith, Darren L, Hueber, Axel J, Anderson, Lesley A, Holmes, William M, McKenzie, Andrew N, Xu, Damo, Sattar, Naveed, McInnes, Iain B, Liew, Foo Y

“…RATIONALE:Chronic low-grade inflammation involving adipose tissue likely contributes to the metabolic consequences of obesity. The cytokine interleukin (IL)-33…”
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The role of microRNA-155/liver X receptor pathway in experimental and idiopathic pulmonary fibrosis by Kurowska-Stolarska, Mariola, PhD, Hasoo, Manhl K., PhD, Welsh, David J., PhD, Stewart, Lynn, BSc, McIntyre, Donna, PhD, Morton, Brian E., BSc, Johnstone, Steven, PhD, Miller, Ashley M., PhD, Asquith, Darren L., PhD, Millar, Neal L., MD, PhD, Millar, Ann B., MD, Feghali-Bostwick, Carol A., PhD, Hirani, Nikhil, MBChB, PhD, Crick, Peter J., PhD, Wang, Yuqin, PhD, Griffiths, William J., PhD, McInnes, Iain B., MD, PhD, McSharry, Charles, PhD

“…Background Idiopathic pulmonary fibrosis (IPF) is progressive and rapidly fatal. Improved understanding of pathogenesis is required to prosper novel…”
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Secukinumab efficacy on resolution of enthesitis in psoriatic arthritis: pooled analysis of two phase 3 studies by Coates, Laura C, Wallman, Johan K, McGonagle, Dennis, Schett, Georg A, McInnes, Iain B, Mease, Philip J, Rasouliyan, Lawrence, Quebe-Fehling, Erhard, Asquith, Darren L, Fasth, Andreas E R, Pricop, Luminita, Gaillez, Corine

“…Enthesitis is one of the psoriatic arthritis (PsA) domains. Patients with enthesitis are associated with worse outcomes than those without enthesitis. The…”
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Soluble ST2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes? by Miller, Ashley M, Purves, David, McConnachie, Alex, Asquith, Darren L, Batty, G David, Burns, Harry, Cavanagh, Jonathan, Ford, Ian, McLean, Jennifer S, Packard, Chris J, Shiels, Paul G, Turner, Helen, Velupillai, Yoga N, Deans, Kevin A, Welsh, Paul, McInnes, Iain B, Sattar, Naveed

“…Preliminary data mostly from animal models suggest the sST2/IL-33 pathway may have causal relevance for vascular disease and diabetes and thus point to a…”
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CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunity by Bunting, Mark D., Comerford, Iain, Seach, Natalie, Hammett, Maree V., Asquith, Darren L., Körner, Heinrich, Boyd, Richard L., Nibbs, Robert J.B., McColl, Shaun R.

“…The atypical chemokine receptor CCX-CKR regulates bioavailability of CCL19, CCL21, and CCL25, homeostatic chemokines that play crucial roles in thymic…”
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Embracing novel cytokines in RA – complexity grows as does opportunity by Hueber, Axel J., MD, Asquith, Darren L., PhD, McInnes, Iain B., FRCP, PhD, FRSE, Miller, Ashley M., PhD, BHF

“…Current therapeutics for the treatment of rheumatoid arthritis (RA) offer limited efficacy in a restricted number of patients. There is, therefore, an unmet…”
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ACKR4 on Stromal Cells Scavenges CCL19 To Enable CCR7-Dependent Trafficking of APCs from Inflamed Skin to Lymph Nodes by Bryce, Steven A, Wilson, Ruairi A M, Tiplady, Eleanor M, Asquith, Darren L, Bromley, Shannon K, Luster, Andrew D, Graham, Gerard J, Nibbs, Robert J B

“…Dermal dendritic cells and epidermal Langerhans cells are APCs that migrate from skin to draining lymph nodes (LN) to drive peripheral tolerance and adaptive…”
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IL‐33 induces skin inflammation with mast cell and neutrophil activation by Hueber, Axel J., Alves‐Filho, Jose C., Asquith, Darren L., Michels, Chesney, Millar, Neal L., Reilly, James H., Graham, Gerry J., Liew, Foo Y., Miller, Ashley M., McInnes, Iain B.

“…Psoriasis is a common chronic autoimmune condition of the skin characterized by hyperplasia of epidermal keratinocytes associated with pro‐inflammatory…”
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Quantitative Detection of Human Tumor Necrosis Factor α by a Resonance Raman Enzyme-Linked Immunosorbent Assay by Laing, Stacey, Hernandez-Santana, Aaron, Sassmannshausen, Jörg, Asquith, Darren L, McInnes, Iain B, Faulds, Karen, Graham, Duncan

“…Tumor necrosis factor α is an inflammatory cytokine which has been linked with many infectious and inflammatory diseases. Detection and quantification of this…”
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Targeting cell migration in rheumatoid arthritis by Asquith, Darren L, Bryce, Steven A, Nibbs, Robert J.B

“…PURPOSE OF REVIEWTo provide an update of past failures, future prospects and key challenges facing the therapeutic targeting of chemokines and their receptors…”
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Collagen-induced arthritis is not impaired in mast cell-deficient mice by Pitman, Nick, Asquith, Darren L, Murphy, Grace, Liew, Foo Y, McInnes, Iain B

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Emerging cytokine targets in rheumatoid arthritis by Asquith, Darren L, McInnes, Iain B

“…PURPOSE OF REVIEWThe utility of cytokines as therapeutic targets in rheumatoid arthritis has been unequivocally demonstrated by the success of tumour necrosis…”
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Simultaneous activation of the liver X receptors (LXRα and LXRβ) drives murine collagen-induced arthritis disease pathology by Asquith, Darren L, Miller, Ashley M, Reilly, James, Kerr, Shauna, Welsh, Paul, Sattar, Naveed, McInnes, Iain B

“…It has previously been shown that dual activation of the Liver X Receptors (LXRα and LXRβ) by the agonist, GW3965, enhances pathology in a murine model of…”
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IL-33 reduces the development of atherosclerosis by Miller, Ashley M., Xu, Damo, Asquith, Darren L., Denby, Laura, Li, Yubin, Sattar, Naveed, Baker, Andrew H., McInnes, Iain B., Liew, Foo Y.

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Liver X receptor agonism promotes articular inflammation in murine collagen‐induced arthritis by Asquith, Darren L., Miller, Ashley M., Hueber, Axel J., McKinnon, Heather J., Sattar, Naveed, Graham, Gerry J., McInnes, Iain B.

“…Objective Liver X receptors (LXRs) have previously been implicated in the regulation of inflammation and have, in general, been ascribed an antiinflammatory…”
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255 Secukinumab provides rapid and sustained resolution of enthesitis in psoriatic arthritis patients: pooled analysis of two Phase 3 studies, FUTURE 2 and FUTURE 3 by Coates, Laura C, McGonagle, Dennis, Schett, Georg, Mease, Philip J, Quebe-Fehling, Erhard, Asquith, Darren L, Rasouliyan, Lawrence, Mpofu, Shepard, Gaillez, Corine

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