Search Results - "Aspden, Julie L."

Long non‐coding RNAs in development and disease: conservation to mechanisms by Tsagakis, Ioannis, Douka, Katerina, Birds, Isabel, Aspden, Julie L

“…Our genomes contain the blueprint of what makes us human and many indications as to why we develop disease. Until the last 10 years, most studies had focussed…”
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Standardized annotation of translated open reading frames by Mudge, Jonathan M., Ruiz-Orera, Jorge, Prensner, John R., Brunet, Marie A., Calvet, Ferriol, Jungreis, Irwin, Gonzalez, Jose Manuel, Magrane, Michele, Martinez, Thomas F., Schulz, Jana Felicitas, Yang, Yucheng T., Albà, M. Mar, Aspden, Julie L., Baranov, Pavel V., Bazzini, Ariel A., Bruford, Elspeth, Martin, Maria Jesus, Calviello, Lorenzo, Carvunis, Anne-Ruxandra, Chen, Jin, Couso, Juan Pablo, Deutsch, Eric W., Flicek, Paul, Frankish, Adam, Gerstein, Mark, Hubner, Norbert, Ingolia, Nicholas T., Kellis, Manolis, Menschaert, Gerben, Moritz, Robert L., Ohler, Uwe, Roucou, Xavier, Saghatelian, Alan, Weissman, Jonathan S., van Heesch, Sebastiaan

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Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching by Hopes, Tayah, Norris, Karl, Agapiou, Michaela, McCarthy, Charley G P, Lewis, Philip A, O’Connell, Mary J, Fontana, Juan, Aspden, Julie L

“…Abstract Ribosomes have long been thought of as homogeneous macromolecular machines, but recent evidence suggests they are heterogeneous and could be…”
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Extensive translation of small Open Reading Frames revealed by Poly-Ribo-Seq by Aspden, Julie L, Eyre-Walker, Ying Chen, Phillips, Rose J, Amin, Unum, Mumtaz, Muhammad Ali S, Brocard, Michele, Couso, Juan-Pablo

“…Thousands of small Open Reading Frames (smORFs) with the potential to encode small peptides of fewer than 100 amino acids exist in our genomes. However, the…”
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Kaposi’s sarcoma-associated herpesvirus induces specialised ribosomes to efficiently translate viral lytic mRNAs by Murphy, James C., Harrington, Elena M., Schumann, Sophie, Vasconcelos, Elton J. R., Mottram, Timothy J., Harper, Katherine L., Aspden, Julie L., Whitehouse, Adrian

“…Historically, ribosomes were viewed as unchanged homogeneous macromolecular machines with no regulatory capacity for mRNA translation. An emerging concept is…”
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Differences in 5'untranslated regions highlight the importance of translational regulation of dosage sensitive genes by Wieder, Nechama, D'Souza, Elston N, Martin-Geary, Alexandra C, Lassen, Frederik H, Talbot-Martin, Jonathan, Fernandes, Maria, Chothani, Sonia P, Rackham, Owen J L, Schafer, Sebastian, Aspden, Julie L, MacArthur, Daniel G, Davies, Robert W, Whiffin, Nicola

“…Untranslated regions (UTRs) are important mediators of post-transcriptional regulation. The length of UTRs and the composition of regulatory elements within…”
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Two new and distinct roles for Drosophila Argonaute-2 in the nucleus: alternative pre-mRNA splicing and transcriptional repression by Taliaferro, J Matthew, Aspden, Julie L, Bradley, Todd, Marwha, Dhruv, Blanchette, Marco, Rio, Donald C

“…Transcription and pre-mRNA alternative splicing are highly regulated processes that play major roles in modulating eukaryotic gene expression. It is…”
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Optimization of Ribosome Footprinting Conditions for Ribo-Seq in Human and Drosophila melanogaster Tissue Culture Cells by Douka, Katerina, Agapiou, Michaela, Birds, Isabel, Aspden, Julie L

“…Our understanding of mRNA translation and its regulation has been transformed by the development of ribosome profiling. This approach relies upon RNase…”
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m6A Regulates the Stability of Cellular Transcripts Required for Efficient KSHV Lytic Replication by Manners, Oliver, Baquero-Perez, Belinda, Mottram, Timothy J., Yonchev, Ivaylo D., Trevelyan, Christopher J., Harper, Katherine L., Menezes, Sarah, Patterson, Molly R., Macdonald, Andrew, Wilson, Stuart A., Aspden, Julie L., Whitehouse, Adrian

“…The epitranscriptomic modification N6-methyladenosine (m6A) is a ubiquitous feature of the mammalian transcriptome. It modulates mRNA fate and dynamics to…”
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A segmental genomic duplication generates a functional intron by Hellsten, Uffe, Aspden, Julie L., Rio, Donald C., Rokhsar, Daniel S.

“…An intron is an extended genomic feature whose function requires multiple constrained positions—donor and acceptor splice sites, a branch point, a…”
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The Drosophila splicing factor PSI is phosphorylated by casein kinase II and tousled-like kinase by Taliaferro, J Matthew, Marwha, Dhruv, Aspden, Julie L, Mavrici, Daniela, Cheng, Nathalie E, Kohlstaedt, Lori A, Rio, Donald C

“…Alternative splicing of pre-mRNA is a highly regulated process that allows cells to change their genetic informational output. These changes are mediated by…”
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Cytoplasmic long noncoding RNAs are differentially regulated and translated during human neuronal differentiation by Douka, Katerina, Birds, Isabel, Wang, Dapeng, Kosteletos, Andreas, Clayton, Sophie, Byford, Abigail, Vasconcelos, Elton J.R., O'Connell, Mary J., Deuchars, Jim, Whitehouse, Adrian, Aspden, Julie L.

“…The expression of long noncoding RNAs is highly enriched in the human nervous system. However, the function of neuronal lncRNAs in the cytoplasm and their…”
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Ribosome Fingerprinting with a Solid-State Nanopore by Raveendran, Mukhil, Leach, Anna Rose, Hopes, Tayah, Aspden, Julie L, Actis, Paolo

“…Nanopores hold great potential for the analysis of complex biological molecules at the single-entity level. One particularly interesting macromolecular machine…”
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Not all exons are protein coding: Addressing a common misconception by Aspden, Julie L., Wallace, Edward W.J., Whiffin, Nicola

“…Exons are regions of DNA that are transcribed to RNA and retained after introns are spliced out. However, the term “exon” is often misused as synonymous to…”
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m[sup.6]A Regulates the Stability of Cellular Transcripts Required for Efficient KSHV Lytic Replication by Manners, Oliver, Baquero-Perez, Belinda, Mottram, Timothy J, Yonchev, Ivaylo D, Trevelyan, Christopher J, Harper, Katherine L, Menezes, Sarah, Patterson, Molly R, Macdonald, Andrew, Wilson, Stuart A, Aspden, Julie L, Whitehouse, Adrian

“…The epitranscriptomic modification N[sup.6] -methyladenosine (m[sup.6] A) is a ubiquitous feature of the mammalian transcriptome. It modulates mRNA fate and…”
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Gene Fusions Derived by Transcriptional Readthrough are Driven by Segmental Duplication in Human by McCartney, Ann M, Hyland, Edel M, Cormican, Paul, Moran, Raymond J, Webb, Andrew E, Lee, Kate D, Hernandez-Rodriguez, Jessica, Prado-Martinez, Javier, Creevey, Christopher J, Aspden, Julie L, McInerney, James O, Marques-Bonet, Tomas, O'Connell, Mary J

“…Gene fusion occurs when two or more individual genes with independent open reading frames becoming juxtaposed under the same open reading frame creating a new…”
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Differential effects of nucleotide analogs on scanning-dependent initiation and elongation of mammalian mRNA translation in vitro by Aspden, Julie L, Jackson, Richard J

“…Codon-anticodon interactions are central to both the initiation and elongation phases of eukaryotic mRNA translation. The obvious difference is that the…”
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Identification and experimental validation of splicing regulatory elements in Drosophila melanogaster reveals functionally conserved splicing enhancers in metazoans by Brooks, Angela N, Aspden, Julie L, Podgornaia, Anna I, Rio, Donald C, Brenner, Steven E

“…RNA sequence elements involved in the regulation of pre-mRNA splicing have previously been identified in vertebrate genomes by computational methods. Here, we…”
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m 6 A Regulates the Stability of Cellular Transcripts Required for Efficient KSHV Lytic Replication by Manners, Oliver, Baquero-Perez, Belinda, Mottram, Timothy J, Yonchev, Ivaylo D, Trevelyan, Christopher J, Harper, Katherine L, Menezes, Sarah, Patterson, Molly R, Macdonald, Andrew, Wilson, Stuart A, Aspden, Julie L, Whitehouse, Adrian

“…The epitranscriptomic modification -methyladenosine (m A) is a ubiquitous feature of the mammalian transcriptome. It modulates mRNA fate and dynamics to exert…”
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