Search Results - "Asokan, Anbanandam"

Aqueous synthesis of a small-molecule lanthanide chelator amenable to copper-free click chemistry by Bishop, Stephanie C, Winefield, Robert, Anbanandam, Asokan, Lampe, Jed N

“…The lanthanides (Ln3+), or rare earth elements, have proven to be useful tools for biomolecular NMR, X-ray crystallographic, and fluorescence analyses due to…”
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Natural product (−)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1 by Lan, Lan, Appelman, Carl, Smith, Amber R., Yu, Jia, Larsen, Sarah, Marquez, Rebecca T., Liu, Hao, Wu, Xiaoqing, Gao, Philip, Roy, Anuradha, Anbanandam, Asokan, Gowthaman, Ragul, Karanicolas, John, De Guzman, Roberto N., Rogers, Steven, Aubé, Jeffrey, Ji, Min, Cohen, Robert S., Neufeld, Kristi L., Xu, Liang

“…Musashi-1 (MSI1) is an RNA-binding protein that acts as a translation activator or repressor of target mRNAs. The best-characterized MSI1 target is Numb mRNA,…”
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Insights into Transcription Enhancer Factor 1 (TEF-1) Activity from the Solution Structure of the TEA Domain by Anbanandam, Asokan, Albarado, Diana C., Nguyen, Catherine T., Halder, Georg, Gao, Xiaolian, Veeraraghavan, Sudha

“…Transcription enhancer factor 1 is essential for cardiac, skeletal, and smooth muscle development and uses its N-terminal TEA domain (TEAD) to bind M-CAT…”
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Calmodulin Directly Interacts with the Cx43 Carboxyl-Terminus and Cytoplasmic Loop Containing Three ODDD-Linked Mutants (M147T, R148Q, and T154A) that Retain α-Helical Structure, but Exhibit Loss-of-Function and Cellular Trafficking Defects by Zheng, Li, Chenavas, Sylvie, Kieken, Fabien, Trease, Andrew, Brownell, Sarah, Anbanandam, Asokan, Sorgen, Paul L, Spagnol, Gaelle

“…The autosomal-dominant pleiotropic disorder called oculodentodigital dysplasia (ODDD) is caused by mutations in the gap junction protein Cx43. Of the 73…”
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Molecular Basis for Proline- and Arginine-Rich Peptide Inhibition of Proteasome by Anbanandam, Asokan, Albarado, Diana C., Tirziu, Daniela C., Simons, Michael, Veeraraghavan, Sudha

“…PR39, a naturally occurring and cell-permeable proline- and arginine-rich peptide, blocks the degradation of inhibitor of nuclear factor κB (IκBα), thereby…”
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Atypical response regulator ChxR from Chlamydia trachomatis is structurally poised for DNA binding by Barta, Michael L, Hickey, John M, Anbanandam, Asokan, Dyer, Kevin, Hammel, Michal, Hefty, P Scott

“…ChxR is an atypical two-component signal transduction response regulator (RR) of the OmpR/PhoB subfamily encoded by the obligate intracellular bacterial…”
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The MDMX Acidic Domain Uses Allovalency to Bind Both p53 and MDMX by Fenton, Malissa, Borcherds, Wade, Chen, Lihong, Anbanandam, Asokan, Levy, Robin, Chen, Jiandong, Daughdrill, Gary

“…Autoinhibition of p53 binding to MDMX requires two short-linear motifs (SLiMs) containing adjacent tryptophan (WW) and tryptophan-phenylalanine (WF) residues…”
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Structural Adaptation of Secondary p53 Binding Sites on MDM2 and MDMX by Higbee, Pirada Serena, Dayhoff, Guy W., Anbanandam, Asokan, Varma, Sameer, Daughdrill, Gary

“…[Display omitted] •Evaluated the secondary p53 binding site of MDM2/X with heat capacity measurements.•Estimated conformational entropy changes with…”
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Oxidation of Met144 and Met145 in Calmodulin Blocks Calmodulin Dependent Activation of the Plasma Membrane Ca-ATPase by Bartlett, Ryan K, Bieber Urbauer, Ramona J, Anbanandam, Asokan, Smallwood, Heather S, Urbauer, Jeffrey L, Squier, Thomas C

“…Methionine oxidation in calmodulin (CaM) isolated from senescent brain results in an inability to fully activate the plasma membrane (PM) Ca-ATPase, which may…”
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Characterization of Small-Molecule Scaffolds That Bind to the Shigella TypeIII Secretion System Protein IpaD by Dey, Supratim, Anbanandam, Asokan, Mumford, Ben E, DeGuzman, Roberto N

“…Many pathogens such as Shigella and other bacteria assemble the typeIII secretion system (T3SS) nanoinjector to inject virulence proteins into their target…”
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Solution 1H NMR of the Active Site of Substrate-bound, Cyanide-inhibited Human Heme Oxygenase by La Mar, Gerd N., Asokan, Anbanandam, Espiritu, Bryan, Yeh, Deok Cheon, Auclair, Karine, Ortiz de Montellano, Paul R.

“…The majority of the active site residues of cyanide-inhibited, substrate-bound human heme oxygenase have been assigned on the basis of two-dimensional NMR…”
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DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites by Gowthaman, Ragul, Miller, Sven A, Rogers, Steven, Khowsathit, Jittasak, Lan, Lan, Bai, Nan, Johnson, David K, Liu, Chunjing, Xu, Liang, Anbanandam, Asokan, Aubé, Jeffrey, Roy, Anuradha, Karanicolas, John

“…Protein–protein interactions represent an exciting and challenging target class for therapeutic intervention using small molecules. Protein interaction sites…”
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Characterization of the Binding of Hydroxyindole, Indoleacetic acid, and Morpholinoaniline to the Salmonella TypeIII Secretion System Proteins SipD and SipB by McShan, Andrew C, Anbanandam, Asokan, Patnaik, Sikta, DeGuzman, Roberto N

“…Many Gram-negative bacteria require the typeIII secretion system (T3SS) to cause infectious diseases in humans. A looming public health problem is that all…”
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Probing the interaction between cHAVc3 peptide and the EC1 domain of E-cadherin using NMR and molecular dynamics simulations by Alaofi, Ahmed, Farokhi, Elinaz, Prasasty, Vivitri D., Anbanandam, Asokan, Kuczera, Krzysztof, Siahaan, Teruna J.

“…The goal of this work is to probe the interaction between cyclic cHAVc3 peptide and the EC1 domain of human E-cadherin protein. Cyclic cHAVc3 peptide…”
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Characterization of Small‐Molecule Scaffolds That Bind to the Shigella Type III Secretion System Protein IpaD by Dey, Supratim, Anbanandam, Asokan, Mumford, Ben E., De Guzman, Roberto N.

“…Many pathogens such as Shigella and other bacteria assemble the type III secretion system (T3SS) nanoinjector to inject virulence proteins into their target…”
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Solution 1H NMR of the Molecular and Electronic Structure of the Heme Cavity and Substrate Binding Pocket of High-Spin Ferric Horseradish Peroxidase:  Effect of His42Ala Mutation by Asokan, Anbanandam, de Ropp, Jeffrey S, Newmyer, Sherri L, Ortiz de Montellano, Paul R, La Mar, Gerd N

“…Solution 1H NMR has been used to assign a major portion of the heme environment and the substrate-binding pocket of resting state horseradish peroxidase, HRP,…”
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Calmodulin Directly Interacts with the Cx43 Carboxyl-Terminus and Cytoplasmic Loop Containing Three ODDD-Linked Mutants that Retain a-Helical Structure, but Exhibit Loss-of-Function and Cellular Trafficking Defects by Zheng, Li, Chenavas, Sylvie, Kieken, Fabien, Trease, Andrew, Brownell, Sarah, Anbanandam, Asokan, Sorgen, Paul L, Spagnol, Gaelle

“…The autosomal-dominant pleiotropic disorder called oculodentodigital dysplasia (ODDD) is caused by mutations in the gap junction protein Cx43. Of the 73…”
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Characterization of the Binding of Hydroxyindole, Indoleacetic acid, and Morpholinoaniline to the Salmonella Type III Secretion System Proteins SipD and SipB by McShan, Andrew C., Anbanandam, Asokan, Patnaik, Sikta, De Guzman, Roberto N.

“…Many Gram‐negative bacteria require the type III secretion system (T3SS) to cause infectious diseases in humans. A looming public health problem is that all…”
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Abstract LB-103: Structural characterization of SPRY2-Cbl interactions by Zhang, Na, Zhang, Xuan, Washington, Laurie, Anbanandam, Asokan, Battaile, Kevin, Gao, Philip, Smalter Hall, Aaron, Lovell, Scott, Roy, Anuradha, Hanzlik, Robert, Perez, Raymond

“…Sprouty 2 (SPRY2) is a feedback modulator of receptor tyrosine kinase (RTK)-ERK signaling, and a potential tumor suppressor. Cbl, an E3 ubiquitin ligase and…”
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Structural and dynamics characterization of norovirus protease by Takahashi, Daisuke, Hiromasa, Yasuaki, Kim, Yunjeong, Anbanandam, Asokan, Yao, Xiaolan, Chang, Kyeong‐Ok, Prakash, Om

“…Norovirus protease is an essential enzyme for proteolytic maturation of norovirus nonstructural proteins and has been implicated as a potential target for…”
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