Search Results - "Aslanyan, Mariam"

Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction by Tiosano, Dov, Baris, Hagit N, Chen, Anlu, Hitzert, Marrit M, Schueler, Markus, Gulluni, Federico, Wiesener, Antje, Bergua, Antonio, Mory, Adi, Copeland, Brett, Gleeson, Joseph G, Rump, Patrick, van Meer, Hester, Sival, Deborah A, Haucke, Volker, Kriwinsky, Josh, Knaup, Karl X, Reis, André, Hauer, Nadine N, Hirsch, Emilio, Roepman, Ronald, Pfundt, Rolph, Thiel, Christian T, Wiesener, Michael S, Aslanyan, Mariam G, Buchner, David A

“…PIK3C2A is a class II member of the phosphoinositide 3-kinase (PI3K) family that catalyzes the phosphorylation of phosphatidylinositol (PI) into PI(3)P and the…”
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Acquired mutations in TET2 are common in myelodysplastic syndromes by Jansen, Joop H, Langemeijer, Saskia M C, Kuiper, Roland P, Berends, Marieke, Knops, Ruth, Aslanyan, Mariam G, Massop, Marion, Stevens-Linders, Ellen, van Hoogen, Patricia, van Kessel, Ad Geurts, Raymakers, Reinier A P, Kamping, Eveline J, Verhoef, Gregor E, Verburgh, Estelle, Hagemeijer, Anne, Vandenberghe, Peter, de Witte, Theo, van der Reijden, Bert A

“…Myelodysplastic syndromes (MDS) represent a heterogeneous group of neoplastic hematopoietic disorders. Several recurrent chromosomal aberrations have been…”
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Characterization of acute myeloid leukemia based on levels of global hydroxymethylation by Kroeze, Leonie I., Aslanyan, Mariam G., van Rooij, Arno, Koorenhof-Scheele, Theresia N., Massop, Marion, Carell, Thomas, Boezeman, Jan B., Marie, Jean-Pierre, Halkes, Constantijn J.M., de Witte, Theo, Huls, Gerwin, Suciu, Stefan, Wevers, Ron A., van der Reijden, Bert A., Jansen, Joop H.

“…Patients with acute myeloid leukemia (AML) frequently harbor mutations in genes involved in the DNA (hydroxy)methylation pathway (DNMT3A, TET2, IDH1, and…”
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DLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2 by Rezi, Csenge K, Aslanyan, Mariam G, Diwan, Gaurav D, Cheng, Tao, Chamlali, Mohamed, Junger, Katrin, Anvarian, Zeinab, Lorentzen, Esben, Pauly, Kleo B, Afshar-Bahadori, Yasmin, Fernandes, Eduardo FA, Qian, Feng, Tosi, Sébastien, Christensen, Søren T, Pedersen, Stine F, Strømgaard, Kristian, Russell, Robert B, Miner, Jeffrey H, Mahjoub, Moe R, Boldt, Karsten, Roepman, Ronald, Pedersen, Lotte B

“…Polarized vesicular trafficking directs specific receptors and ion channels to cilia, but the underlying mechanisms are poorly understood. Here we describe a…”
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A targeted multi-proteomics approach generates a blueprint of the ciliary ubiquitinome by Aslanyan, Mariam G, Doornbos, Cenna, Diwan, Gaurav D, Anvarian, Zeinab, Beyer, Tina, Junger, Katrin, van Beersum, Sylvia E C, Russell, Robert B, Ueffing, Marius, Ludwig, Alexander, Boldt, Karsten, Pedersen, Lotte B, Roepman, Ronald

“…Establishment and maintenance of the primary cilium as a signaling-competent organelle requires a high degree of fine tuning, which is at least in part…”
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TET proteins in malignant hematopoiesis by Langemeijer, Saskia M.C., Aslanyan, Mariam G., Jansen, Joop H.

“…Differentiation of hematopoietic stem cells into mature blood cells is a multistage process. During each stage, both extrinsic and intrinsic factors coordinate…”
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Clinical and biological impact of TET2 mutations and expression in younger adult AML patients treated within the EORTC/GIMEMA AML-12 clinical trial by Aslanyan, Mariam G., Kroeze, Leonie I., Langemeijer, Saskia M. C., Koorenhof-Scheele, Theresia N., Massop, Marion, van Hoogen, Patricia, Stevens-Linders, Ellen, van de Locht, Louis T., Tönnissen, Evelyn, van der Heijden, Adrian, da Silva-Coelho, Pedro, Cilloni, Daniela, Saglio, Giuseppe, Marie, Jean-Pierre, Tang, Ruoping, Labar, Boris, Amadori, Sergio, Muus, Petra, Willemze, Roel, Marijt, Erik W. A., de Witte, Theo, van der Reijden, Bert A., Suciu, Stefan, Jansen, Joop H.

“…We assessed the prognostic impact of TET2 mutations and mRNA expression in a prospective cohort of 357 adult AML patients < 60 years of age enrolled in the…”
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The mitotic spindle protein SPAG5/Astrin connects to the Usher protein network postmitotically by Kersten, Ferry Fj, van Wijk, Erwin, Hetterschijt, Lisette, Bauβ, Katharina, Peters, Theo A, Aslanyan, Mariam G, van der Zwaag, Bert, Wolfrum, Uwe, Keunen, Jan Ee, Roepman, Ronald, Kremer, Hannie

“…Mutations in the gene for Usher syndrome 2A (USH2A) are causative for non-syndromic retinitis pigmentosa and Usher syndrome, a condition that is the most…”
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Primary Cilia Change Protein Composition in Response to Glutamine Deprivation: FR-PO584 by Nielsen, Anne K., Steidl, Maria Elena, Aslanyan, Mariam, Beersum, Sylvia E. van, Spies, Daniel, Pedersen, Lotte B., Boldt, Karsten, Roepman, Ronald, Boletta, Alessandra

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Primary cilia sense glutamine availability and respond via asparagine synthetase by Steidl, Maria Elena, Nigro, Elisa A., Nielsen, Anne Kallehauge, Pagliarini, Roberto, Cassina, Laura, Lampis, Matteo, Podrini, Christine, Chiaravalli, Marco, Mannella, Valeria, Distefano, Gianfranco, Yang, Ming, Aslanyan, Mariam, Musco, Giovanna, Roepman, Ronald, Frezza, Christian, Boletta, Alessandra

“…Depriving cells of nutrients triggers an energetic crisis, which is resolved by metabolic rewiring and organelle reorganization. Primary cilia are…”
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Aberrant 5-Hydroxymethylcytosine Levels Correlate With Poor Overall Survival In Acute Myeloid Leukemia by Kroeze, Leonie I, Aslanyan, Mariam G, van Rooij, Arno, Koorenhof-Scheele, Theresia N, Massop, Marion, Carell, Thomas, Boezeman, Jan B, Marie, Jean-Pierre, Halkes, Constantijn J.M., de Witte, Theo M., Huls, Gerwin, Suciu, Stefan, Wevers, Ron, van der Reijden, Bert A., Jansen, Joop H.

“…Patients with acute myeloid leukemia (AML) frequently harbor mutations in genes involved in the DNA (hydroxy)methylation pathway (DNMT3A, TET2, IDH1, and…”
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