Search Results - "Aslanoglou, Despoina"

New roles for dopamine D2 and D3 receptors in pancreatic beta cell insulin secretion by Farino, Zachary J., Morgenstern, Travis J., Maffei, Antonella, Quick, Matthias, De Solis, Alain J., Wiriyasermkul, Pattama, Freyberg, Robin J., Aslanoglou, Despoina, Sorisio, Denise, Inbar, Benjamin P., Free, R. Benjamin, Donthamsetti, Prashant, Mosharov, Eugene V., Kellendonk, Christoph, Schwartz, Gary J., Sibley, David R., Schmauss, Claudia, Zeltser, Lori M., Moore, Holly, Harris, Paul E., Javitch, Jonathan A., Freyberg, Zachary

“…Although long-studied in the central nervous system, there is increasing evidence that dopamine (DA) has important roles in the periphery including in…”
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Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors by Aslanoglou, Despoina, Bertera, Suzanne, Sánchez-Soto, Marta, Benjamin Free, R., Lee, Jeongkyung, Zong, Wei, Xue, Xiangning, Shrestha, Shristi, Brissova, Marcela, Logan, Ryan W., Wollheim, Claes B., Trucco, Massimo, Yechoor, Vijay K., Sibley, David R., Bottino, Rita, Freyberg, Zachary

“…Dopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the central nervous system that also act in the pancreas as peripheral regulators…”
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Gq/11-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR by White, Alex D., Jean-Alphonse, Frederic G., Fang, Fei, Peña, Karina A., Liu, Shi, König, Gabriele M., Inoue, Asuka, Aslanoglou, Despoina, Gellman, Samuel H., Kostenis, Evi, Xiao, Kunhong, Vilardaga, Jean-Pierre

“…cAMP production upon activation of Gs by G protein-coupled receptors has classically been considered to be plasma membranedelimited, but a shift in this…”
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Intrinsic and Antipsychotic Drug-Induced Metabolic Dysfunction in Schizophrenia by Freyberg, Zachary, Aslanoglou, Despoina, Shah, Ripal, Ballon, Jacob S

“…For decades, there have been observations demonstrating significant metabolic disturbances in people with schizophrenia including clinically relevant weight…”
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Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine by Aslanoglou, Despoina, Bertera, Suzanne, Friggeri, Laura, Sánchez-Soto, Marta, Lee, Jeongkyung, Xue, Xiangning, Logan, Ryan W., Lane, J. Robert, Yechoor, Vijay K., McCormick, Peter J., Meiler, Jens, Free, R. Benjamin, Sibley, David R., Bottino, Rita, Freyberg, Zachary

“…Bromocriptine is approved as a diabetes therapy, yet its therapeutic mechanisms remain unclear. Though bromocriptine’s actions have been mainly attributed to…”
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Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion by Aslanoglou, Despoina, George, Emily W., Freyberg, Zachary

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Distinct Agonist Regulation of Muscarinic Acetylcholine M2-M3 Heteromers and Their Corresponding Homomers by Aslanoglou, Despoina, Alvarez-Curto, Elisa, Marsango, Sara, Milligan, Graeme

“…Each subtype of the muscarinic receptor family of G protein-coupled receptors is activated by similar concentrations of the neurotransmitter acetylcholine or…”
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Dopamine D2 receptor signaling modulates pancreatic beta cell circadian rhythms by Wei, Heather, Zapata, Rizaldy C., Lopez-Valencia, Mariela, Aslanoglou, Despoina, Farino, Zachary J., Benner, Valerie, Osborn, Olivia, Freyberg, Zachary, McCarthy, Michael J.

“…Antipsychotic drugs disrupt dopamine-circadian interactions in pancreatic beta cells. Under physiological conditions, reciprocal connections link the circadian…”
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Dopamine D 2 receptor signaling modulates pancreatic beta cell circadian rhythms by Wei, Heather, Zapata, Rizaldy C, Lopez-Valencia, Mariela, Aslanoglou, Despoina, Farino, Zachary J, Benner, Valerie, Osborn, Olivia, Freyberg, Zachary, McCarthy, Michael J

“…Antipsychotic drugs (APD) have clinically important, adverse effects on metabolism that limit their therapeutic utility. Pancreatic beta cells produce dopamine…”
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Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia by Bonifazi, Alessandro, Ellenberger, Michael, Farino, Zachary J, Aslanoglou, Despoina, Rais, Rana, Pereira, Sandra, Mantilla-Rivas, José O, Boateng, Comfort A, Eshleman, Amy J, Janowsky, Aaron, Hahn, Margaret K, Schwartz, Gary J, Slusher, Barbara S, Newman, Amy Hauck, Freyberg, Zachary

“…Dopamine (DA) D2-like receptors in both the central nervous system (CNS) and the periphery are key modulators of metabolism. Moreover, disruption of D2-like…”
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1299-P: Novel Tools to Dissect the Metabolic Roles of Central and Peripheral Dopamine D2-Like Receptors by BONIFAZI, ALESSANDRO, ELLENBERGER, MICHAEL P., FARINO, ZACHARY, RAIS, RANA, MANTILLA-RIVAS, JOSÉ, ASLANOGLOU, DESPOINA, JANOWSKY, AARON, SLUSHER, BARBARA, SCHWARTZ, GARY J., NEWMAN, AMY H., FREYBERG, ZACHARY

“…Dopamine (DA) D2-like receptors are key physiological modulators of metabolism under healthy and disease states. While D2-like receptors are expressed both in…”
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1472-P: Dual Pancreatic Adrenergic and Dopaminergic Signaling as a Therapeutic Mechanism for Treatment of Dysglycemia by Bromocriptine by ASLANOGLOU, DESPOINA, BERTERA, SUZANNE, FRIGGERI, LAURA, SOTO, MARTA SANCHEZ, LEE, JEONGKYUNG, XUE, XIANGNING, LOGAN, RYAN, LANE, ROB, YECHOOR, VIJAY, FREE, R BENJAMIN, SIBLEY, DAVID R., BOTTINO, RITA, FREYBERG, ZACHARY

“…Dopaminergic agonism effectively treats dysglycemia, with dopaminergic agonist bromocriptine approved as a type 2 diabetes therapy. Though bromocriptine’s…”
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Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion by Aslanoglou, Despoina, George, Emily W, Freyberg, Zachary

“…The detection of insulin secretion is critical for elucidating mechanisms of regulated secretion as well as in studies of metabolism. Though numerous insulin…”
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Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age‐related neurodegeneration by Buck, Silas A., Steinkellner, Thomas, Aslanoglou, Despoina, Villeneuve, Michael, Bhatte, Sai H., Childers, Victoria C., Rubin, Sophie A., De Miranda, Briana R., O'Leary, Emma I., Neureiter, Elizabeth G., Fogle, Keri J., Palladino, Michael J., Logan, Ryan W., Glausier, Jill R., Fish, Kenneth N., Lewis, David A., Greenamyre, J. Timothy, McCabe, Brian D., Cheetham, Claire E. J., Hnasko, Thomas S., Freyberg, Zachary

“…Age is the greatest risk factor for Parkinson's disease (PD) which causes progressive loss of dopamine (DA) neurons, with males at greater risk than females…”
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G q/11 -dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR by White, Alex D, Jean-Alphonse, Frederic G, Fang, Fei, Peña, Karina A, Liu, Shi, König, Gabriele M, Inoue, Asuka, Aslanoglou, Despoina, Gellman, Samuel H, Kostenis, Evi, Xiao, Kunhong, Vilardaga, Jean-Pierre

“…cAMP production upon activation of G by G protein-coupled receptors has classically been considered to be plasma membrane-delimited, but a shift in this…”
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Development of Melanocortin 4 Receptor Agonists by Exploiting Animal-Derived Macrocyclic, Disulfide-Rich Peptide Scaffolds by Muratspahić, Edin, Aslanoglou, Despoina, White, Andrew M., Draxler, Claudia, Kozisek, Xaver, Farooq, Zara, Craik, David J., McCormick, Peter J., Durek, Thomas, Gruber, Christian W.

“…G protein-coupled receptors are among the most widely studied classes of drug targets. A major challenge in this field is to develop ligands that will…”
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50. New Roles for Peripheral Dopamine D2-Like Receptors in Antipsychotic Drug-Induced Metabolic Dysfunction by Freyberg, Zachary, Farino, Zachary, Morgenstern, Travis, Maffei, Antonella, Quick, Matthias, De Solis, Alain, Wiriyasermkul, Pattama, Freyberg, Robin, Aslanoglou, Despoina, Sorisio, Denise, Inbar, Benjamin, Free, R. Benjamin, Donthamsetti, Prashant, Mosharov, Eugene, Kellendonk, Christoph, Schwartz, Gary, Sibley, David, Schmauss, Claudia, Zeltser, Lori, Moore, Holly, Harris, Paul, Javitch, Jonathan

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Ligand regulation of muscarinic acetylcholine receptor organisation by Aslanoglou, Despoina

“…Muscarinic acetylcholine receptors (M1-M5) belong to the class A family of transmembrane G protein coupled receptors (GPCRs) and mediate various signalling…”
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Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells by Carter, Stephen D, Hampton, Cheri M, Langlois, Robert, Melero, Roberto, Farino, Zachary J, Calderon, Michael J, Li, Wen, Wallace, Callen T, Tran, Ngoc Han, Grassucci, Robert A, Siegmund, Stephanie E, Pemberton, Joshua, Morgenstern, Travis J, Eisenman, Leanna, Aguilar, Jenny I, Greenberg, Nili L, Levy, Elana S, Yi, Edward, Mitchell, William G, Rice, William J, Wigge, Christoph, Pilli, Jyotsna, George, Emily W, Aslanoglou, Despoina, Courel, Maïté, Freyberg, Robin J, Javitch, Jonathan A, Wills, Zachary P, Area-Gomez, Estela, Shiva, Sruti, Bartolini, Francesca, Volchuk, Allen, Murray, Sandra A, Aridor, Meir, Fish, Kenneth N, Walter, Peter, Balla, Tamas, Fass, Deborah, Wolf, Sharon G, Watkins, Simon C, Carazo, José María, Jensen, Grant J, Frank, Joachim, Freyberg, Zachary

“…The endoplasmic reticulum (ER) is a highly dynamic network of membranes. Here, we combine live-cell microscopy with in situ cryo-electron tomography to…”
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New roles for dopamine D 2 and D 3 receptors in pancreatic beta cell insulin secretion by Farino, Zachary J, Morgenstern, Travis J, Maffei, Antonella, Quick, Matthias, De Solis, Alain J, Wiriyasermkul, Pattama, Freyberg, Robin J, Aslanoglou, Despoina, Sorisio, Denise, Inbar, Benjamin P, Free, R Benjamin, Donthamsetti, Prashant, Mosharov, Eugene V, Kellendonk, Christoph, Schwartz, Gary J, Sibley, David R, Schmauss, Claudia, Zeltser, Lori M, Moore, Holly, Harris, Paul E, Javitch, Jonathan A, Freyberg, Zachary

“…Although long-studied in the central nervous system, there is increasing evidence that dopamine (DA) has important roles in the periphery including in…”
Get full text