Search Results - "Aslamy, Arianne"

Exocytosis proteins as novel targets for diabetes prevention and/or remediation? by Aslamy, Arianne, Thurmond, Debbie C

“…Diabetes remains one of the leading causes of morbidity and mortality worldwide, affecting an estimated 422 million adults. In the US, it is predicted that one…”
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Steroid signaling mediates longevity responses to the eat-2 genetic model of dietary restriction in Caenorhabditis elegans by Farris, Mindy, Fang, Lily, Aslamy, Arianne, Pineda, Victor

“…Dietary restriction (DR) extends lifespan in a wide range of model organisms, including Caenorhabditis elegans. It is an interesting but yet to be addressed…”
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10-PUB: Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Response to a Lifestyle or Senolytic Intervention in Older Adults with Obesity-A Double-Blind, Placebo-Controlled, Randomized Trial by Connolly, Gavin, Aslamy, Arianne, Nie, Jia, Kabir, Morvarid, Serra, Monica C, Espinoza, Sara E, Musi, Nicolas

“…Introduction & Objective: Older adults with obesity are at an increased risk for metabolic diseases and diabetes. The underlying molecular mechanisms by which…”
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DOC2b Enhances β-Cell Function via a Novel Tyrosine Phosphorylation-Dependent Mechanism by Chatterjee Bhowmick, Diti, Aslamy, Arianne, Bhattacharya, Supriyo, Oh, Eunjin, Ahn, Miwon, Thurmond, Debbie C

“…Double C2 domain Β (DOC2b) protein is required for glucose-stimulated insulin secretion (GSIS) in β-cells, the underlying mechanism of which remains…”
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DOC2b Protects Functional Beta‐cell Mass via A Novel Tyrosine Phosphorylation Dependent Mechanism by Bhowmick, Diti Chatterjee, Aslamy, Arianne, Oh, Eunjin, Ahn, Miwon, Thurmond, Debbie C.

“…Abstract only Type 2 diabetes (T2D) has reached the stage of a global pandemic. Approximately 10% of the total US population (~30 million people) are impacted…”
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THU247 Characterizing Inpatient Cases Of DKA Precipitated By SGLT2 Inhibitor Use by Aslamy, Arianne, Nazemi, Reza, Tseng, Conrad, Kim, Steve, Gianchandani, Roma

“…Abstract Disclosure: A. Aslamy: None. R. Nazemi: Speaker; Self; Eli Lilly & Company, AstraZeneca. C. Tseng: None. S. Kim: None. R. Gianchandani: None…”
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128-OR: DOC2b Boosts Insulin Secretion via a Yes Kinase-Dependent Mechanism by BHOWMICK, DITI CHATTERJEE, ASLAMY, ARIANNE, BHATTACHARYA, SUPRIYO, OH, EUNJIN, AHN, MIWON, THURMOND, DEBBIE C.

“…Exocytosis regulatory protein DOC2b is a crucial regulator of SNARE assembly in β-cells and enrichment of DOC2b enhances glucose-stimulated insulin secretion…”
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Increased Plasma Branched Short-Chain Fatty Acids and Improved Glucose Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) by Aslamy, Arianne, Wood, Alexis C, Jensen, Elizabeth T, Bertoni, Alain G, Sheridan, Patricia A, Wong, Kari E, Ramesh, Gautam, Rotter, Jerome I, Chen, Yii-Der I, Goodarzi, Mark O

“…Short-chain fatty acids (SCFAs) have been extensively studied for potential beneficial roles in glucose homeostasis and risk of diabetes; however, most of this…”
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6711 Single Nuclei RNA-seq To Map Adipose Cellular Populations And Senescent Cells In Response To A Lifestyle Or Senolytic Intervention In Older Adults With Obesity: A Double-Blind, Placebo-Controlled, Randomized Trial by Aslamy, Arianne, Connolly, Gavin, Nie, Jia, Espinoza, Sara, Serra, Monica, Musi, Nicolas

“…Abstract Disclosure: A. Aslamy: None. G. Connolly: None. J. Nie: None. S. Espinoza: None. M. Serra: None. N. Musi: None. It is well established that obese and…”
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DOC2B promotes insulin sensitivity in mice via a novel KLC1-dependent mechanism in skeletal muscle by Zhang, Jing, Oh, Eunjin, Merz, Karla E., Aslamy, Arianne, Veluthakal, Rajakrishnan, Salunkhe, Vishal A., Ahn, Miwon, Tunduguru, Ragadeepthi, Thurmond, Debbie C.

“…Aims/hypothesis Skeletal muscle accounts for >80% of insulin-stimulated glucose uptake; dysfunction of this process underlies insulin resistance and type 2…”
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Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function by Aslamy, Arianne, Oh, Eunjin, Olson, Erika M, Zhang, Jing, Ahn, Miwon, Moin, Abu Saleh Md, Tunduguru, Ragadeepthi, Salunkhe, Vishal A, Veluthakal, Rajakrishnan, Thurmond, Debbie C

“…Loss of functional β-cell mass is an early feature of type 1 diabetes. To release insulin, β-cells require soluble -ethylmaleimide-sensitive factor attachment…”
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The actin-related p41ARC subunit contributes to p21-activated kinase-1 (PAK1)–mediated glucose uptake into skeletal muscle cells by Tunduguru, Ragadeepthi, Zhang, Jing, Aslamy, Arianne, Salunkhe, Vishal A., Brozinick, Joseph T., Elmendorf, Jeffrey S., Thurmond, Debbie C.

“…Defects in translocation of the glucose transporter GLUT4 are associated with peripheral insulin resistance, preclinical diabetes, and progression to type 2…”
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Regulation of Insulin Sensitivity by Skeletal Muscle Specific Modulation Of p21‐Activated Kinase 1 (PAK1) by Salunkhe, Vishal Ashok, Tunduguru, Ragadeepthi, Ahn, Miwon, Olson, Erika M., Veluthakal, Rajakrishnan, Zhang, Jing, Aslamy, Arianne, Thurmond, Debbie C.

“…Impaired skeletal muscle (skm) insulin signaling results in insulin resistance and the development of type 2 diabetes (T2D). Insulin binding to its receptors…”
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Exocytosis Protein DOC2B as a Biomarker of Type 1 Diabetes by Aslamy, Arianne, Oh, Eunjin, Ahn, Miwon, Moin, Abu Saleh Md, Chang, Mariann, Duncan, Molly, Hacker-Stratton, Jeannette, El-Shahawy, Mohamed, Kandeel, Fouad, DiMeglio, Linda A, Thurmond, Debbie C

“…Abstract Context Efforts to preserve β-cell mass in the preclinical stages of type 1 diabetes (T1D) are limited by few blood-derived biomarkers of β-cell…”
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Doc2b Enhancement of Beta Cell Function and Survival by Aslamy, Arianne

“…Diabetes mellitus is a complex metabolic disease that currently affects an estimated 422 million people worldwide, with incidence rates rising annually. Type 1…”
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