Search Results - "Askenasy, Nadir"

Physiological functions of TNF family receptor/ligand interactions in hematopoiesis and transplantation by Mizrahi, Keren, Askenasy, Nadir

“…Secretion of ligands of the tumor necrosis factor (TNF) superfamily is a conserved response of parenchymal tissues to injury and inflammation that commonly…”
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Hematopoietic transplants for disease suppression and cure in type 1 diabetes by Askenasy, Nadir

“…Recent clinical studies have demonstrated the capacity of immunosuppressive therapy to delay progression of inflammatory insulitis in type 1 diabetes (T1D)…”
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Killer Treg cells ameliorate inflammatory insulitis in non-obese diabetic mice through local and systemic immunomodulation by Kaminitz, Ayelet, Yolcu, Esma S, Mizrahi, Keren, Shirwan, Haval, Askenasy, Nadir

“…Treg cells endowed with enhanced killing activity through decoration with Fas-ligand (FasL) protein (killer Treg) have been effective in delay of hyperglycemia…”
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From the atom to the cell: Is the cat alive? Quantum mechanics and stem cell plasticity as déjà vu by Askenasy, Nadir, Nadir, Askenasy

“…The concepts submitted by quantum mechanics fascinated the scientific community during the first half of the 20(th) century. The second half was dominated by…”
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Induction of tolerance using Fas ligand: a double-edged immunomodulator by Askenasy, Nadir, Yolcu, Esma S., Yaniv, Isaac, Shirwan, Haval

“…Apoptosis mediated by Fas ligand (FasL) interaction with Fas receptor plays a pivotal regulatory role in immune homeostasis, immune privilege, and…”
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Two distinct mechanisms mediate the involvement of bone marrow cells in islet remodeling: neogenesis of insulin-producing cells and support of islet recovery by Iskovich, Svetlana, Goldenberg-Cohen, Nitza, Sadikov, Tamila, Yaniv, Isaac, Stein, Jerry, Askenasy, Nadir

“…We have recently reported that small-sized bone marrow cells (BMCs) isolated by counterflow centrifugal elutriation and depleted of lineage markers…”
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Apoptosis of purified CD4+ T cell subsets is dominated by cytokine deprivation and absence of other cells in new onset diabetic NOD mice by Kaminitz, Ayelet, Askenasy, Enosh M, Yaniv, Isaac, Stein, Jerry, Askenasy, Nadir

“…Regulatory T cells (Treg) play a significant role in immune homeostasis and self-tolerance. Excessive sensitivity of isolated Treg to apoptosis has been…”
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Tumor Necrosis Factor Receptors Support Murine Hematopoietic Progenitor Function in the Early Stages of Engraftment by Pearl‐Yafe, Michal, Mizrahi, Keren, Stein, Jerry, Yolcu, Esma S., Kaplan, Ofer, Shirwan, Haval, Yaniv, Isaac, Askenasy, Nadir

“…Tumor necrosis factor (TNF) family receptors/ligands are important participants in hematopoietic homeostasis, in particular as essential negative expansion…”
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Pancreatic islets under attack: cellular and molecular effectors by Pearl-Yafe, Michal, Kaminitz, Ayelet, Yolcu, Esma S, Yaniv, Isaac, Stein, Jerry, Askenasy, Nadir

“…Abundant information is available on the involvement of various cellular and molecular mechanisms in beta cell apoptosis. The experimental evidence is…”
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Graft versus neuroblastoma reaction is efficiently elicited by allogeneic bone marrow transplantation through cytolytic activity in the absence of GVHD by Ash, Shifra, Gigi, Vered, Askenasy, Nadir, Fabian, Ina, Stein, Jerry, Yaniv, Isaac

“…Continuous efforts are dedicated to develop immunotherapeutic approaches to neuroblastoma (NB), a tumor that relapses at high rates following high-dose…”
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Restless Leg Syndrome in Neurologic and Medical Disorders by Askenasy, Nadir, MD, PhD, Askenasy, Jean-Jacques, MD, PhD

“…Adopting prior models of sleep-wake transitions, a flip-flop switch in synchronized neurotransmitter activity is proposed to underlie restless leg syndrome…”
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Immunotherapy for neuroblastoma by hematopoietic cell transplantation and post-transplant immunomodulation by Ash, Shifra, Askenasy, Nadir

“…Neuroblastoma represents a relatively common childhood tumor that imposes therapeutic difficulties. High risk neuroblastoma patients have poor prognosis,…”
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Effector and naturally occurring regulatory T cells display no abnormalities in activation induced cell death in NOD mice by Kaminitz, Ayelet, Yolcu, Esma S, Askenasy, Enosh M, Stein, Jerry, Yaniv, Isaac, Shirwan, Haval, Askenasy, Nadir

“…Disturbed peripheral negative regulation might contribute to evolution of autoimmune insulitis in type 1 diabetes. This study evaluates the sensitivity of…”
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Mechanisms of autoimmunity in the non‐obese diabetic mouse: effector/regulatory cell equilibrium during peak inflammation by Askenasy, Nadir

“…Summary Immune imbalance in autoimmune disorders such as type 1 diabetes may originate from aberrant activities of effector cells or dysfunction of suppressor…”
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Enhanced killing activity of regulatory T cells ameliorates inflammation and autoimmunity by Askenasy, Nadir

“…Abstract Regulatory T cells (Treg) are pivotal suppressor elements in immune homeostasis with potential therapeutic applications in inflammatory and autoimmune…”
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Mechanisms of diabetic autoimmunity: I—the inductive interface between islets and the immune system at onset of inflammation by Askenasy, Nadir

“…The mechanisms of autoimmune reactivity onset in type 1 diabetes (T1D) remain elusive despite extensive experimentation and discussion. We reconsider several…”
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Mechanisms of diabetic autoimmunity: II—Is diabetes a central or peripheral disorder of effector and regulatory cells? by Askenasy, Nadir

“…Two competing hypotheses aiming to explain the onset of autoimmune reactions are discussed in the context of genetic and environmental predisposition to type 1…”
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Interferon and tumor necrosis factor as humoral mechanisms coupling hematopoietic activity to inflammation and injury by Askenasy, Nadir

“…Abstract Enhanced hematopoiesis accompanies systemic responses to injury and infection. Tumor necrosis factor (TNF) produced by injured cells and interferons…”
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Less Is More: The Detrimental Consequences of Immunosuppressive Therapy in the Treatment of Type-1 Diabetes by Askenasy, Nadir

“…The prevalent current approach to type 1 diabetes (T1D) is the abrogation of pathogenic potential by immunosuppressive therapy, an intuitive approach aiming to…”
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Participation of adult bone marrow-derived stem cells in pancreatic regeneration: neogenesis versus endogenesis by Iskovich, Svetlana, Kaminitz, Ayelet, Yafe, Michal Pearl, Mizrahi, Keren, Stein, Jerry, Yaniv, Isaac, Askenasy, Nadir

“…Regenerative medicine opens new avenues and promises towards more effective therapies for autoimmune disorders. Current therapeutic strategies for type I…”
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