Search Results - "Askenase, W"

Rare Skin Reactions after mRNA Vaccination, Similar to Jones–Mote Basophil Responses by Askenase, Philip W

“…The rare florid local reactions to Covid-19 vaccines bear gross and microscopic similarity to previously reported cutaneous basophil hypersensitivity reactions…”
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Ancient Evolutionary Origin and Properties of Universally Produced Natural Exosomes Contribute to Their Therapeutic Superiority Compared to Artificial Nanoparticles by Askenase, Phillip W

“…Extracellular vesicles (EVs), such as exosomes, are newly recognized fundamental, universally produced natural nanoparticles of life that are seemingly…”
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Diagnostic and therapeutic potentials of exosomes in CNS diseases by Kawikova, Ivana, Askenase, Philip W

“…Abstract A newly discovered cell-to-cell communication system involves small, membrane-enveloped nanovesicles, called exosomes. We describe here how these…”
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Exosome Carrier Effects; Resistance to Digestion in Phagolysosomes May Assist Transfers to Targeted Cells; II Transfers of miRNAs Are Better Analyzed via Systems Approach as They Do Not Fit Conventional Reductionist Stoichiometric Concepts by Askenase, Philip W

“…Carrier effects of extracellular vesicles (EV) like exosomes refer to properties of the vesicles that contribute to the transferred biologic effects of their…”
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Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF‐β upregulation, microvascular stabilization and functional recovery in a rodent model of severe spinal cord injury by Nakazaki, Masahito, Morita, Tomonori, Lankford, Karen L., Askenase, Philip W, Kocsis, Jeffery D.

“…Intravenous (IV) infusion of bone marrow‐derived mesenchymal stem/stromal cells (MSCs) stabilizes the blood‐spinal cord barrier (BSCB) and improves functional…”
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Critical role for the chemokine receptor CXCR6 in NK cell–mediated antigen-specific memory of haptens and viruses by Paust, Silke, Gill, Harvinder S, Wang, Bao-Zhong, Flynn, Michael P, Moseman, E Ashley, Senman, Balimkiz, Szczepanik, Marian, Telenti, Amalio, Askenase, Philip W, Compans, Richard W, von Andrian, Ulrich H

“…NK cells confer innate immune functions. Von Andrian and colleagues show that hepatic NK cells bearing CXCR6 receptors confer antigen-specific NK cell memory…”
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Recommendation: Treatment of clinical long COVID encephalopathies with nasal administered mesenchymal stromal cell extracellular vesicles by Askenase, Philip W.

“…We propose therapy with extracellular vesicles (EVs) for dominant central nervous system aspects of chronic Long COVID Syndromes (LCS). These clinical…”
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Free Extracellular miRNA Functionally Targets Cells by Transfecting Exosomes from Their Companion Cells by Bryniarski, Krzysztof, Ptak, Wlodzimierz, Martin, Emilia, Nazimek, Katarzyna, Szczepanik, Marian, Sanak, Marek, Askenase, Philip W

“…Lymph node and spleen cells of mice doubly immunized by epicutaneous and intravenous hapten application produce a suppressive component that inhibits the…”
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Antibody Light Chains Dictate the Specificity of Contact Hypersensitivity Effector Cell Suppression Mediated by Exosomes by Nazimek, Katarzyna, Askenase, Philip W, Bryniarski, Krzysztof

“…Antibody light chains (LCs), formerly considered a waste product of immunoglobulin synthesis, are currently recognized as important players in the activation…”
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Orally Administered Exosomes Suppress Mouse Delayed-Type Hypersensitivity by Delivering miRNA-150 to Antigen-Primed Macrophage APC Targeted by Exosome-Surface Anti-Peptide Antibody Light Chains by Nazimek, Katarzyna, Bryniarski, Krzysztof, Ptak, Wlodzimierz, Groot Kormelink, Tom, Askenase, Philip W

“…We previously discovered suppressor T cell-derived, antigen (Ag)-specific exosomes inhibiting mouse hapten-induced contact sensitivity effector T cells by…”
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Critical Role for NALP3/CIAS1/Cryopyrin in Innate and Adaptive Immunity through Its Regulation of Caspase-1 by Sutterwala, Fayyaz S., Ogura, Yasunori, Szczepanik, Marian, Lara-Tejero, Maria, Lichtenberger, G. Scott, Grant, Ethan P., Bertin, John, Coyle, Anthony J., Galán, Jorge E., Askenase, Philip W., Flavell, Richard A.

“…Mutations in the NALP3/CIAS1/cryopyrin gene are linked to three autoinflammatory disorders: Muckle-Wells syndrome, familial cold autoinflammatory syndrome, and…”
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Delayed-Type Hypersensitivity Underlying Casein Allergy Is Suppressed by Extracellular Vesicles Carrying miRNA-150 by Wąsik, Magdalena, Nazimek, Katarzyna, Nowak, Bernadeta, Askenase, Philip W, Bryniarski, Krzysztof

“…In patients with non-IgE-mediated milk allergy, a cellular mechanism of delayed-type hypersensitivity (DTH) is considered. Recent findings prove that…”
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Syngeneic red blood cell–induced extracellular vesicles suppress delayed‐type hypersensitivity to self‐antigens in mice by Nazimek, Katarzyna, Bustos‐Morán, Eugenio, Blas‐Rus, Noelia, Nowak, Bernadeta, Ptak, Włodzimierz, Askenase, Philip W., Sánchez‐Madrid, Francisco, Bryniarski, Krzysztof

“…Background At present, the role of autologous cells as antigen carriers inducing immune tolerance is appreciated. Accordingly, intravenous administration of…”
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Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity by Bryniarski, Krzysztof, PhD, Ptak, Wlodzimierz, MD, Jayakumar, Asha, PhD, Püllmann, Kerstin, MD, Caplan, Michael J., MD, PhD, Chairoungdua, Arthit, PhD, Lu, Jun, MD, PhD, Adams, Brian D., PhD, Sikora, Emilia, PhD, Nazimek, Katarzyna, MS, Marquez, Susanna, MS, Kleinstein, Steven H., PhD, Sangwung, Panjamaporn, BS, Iwakiri, Yasuko, PhD, Delgato, Eric, BS, Redegeld, Frank, PhD, Blokhuis, Bart R., MS, Wojcikowski, Jacek, PhD, Daniel, Anna Wladyslawa, PhD, Groot Kormelink, Tom, PhD, Askenase, Philip W., MD

“…Background T-cell tolerance of allergic cutaneous contact sensitivity (CS) induced in mice by high doses of reactive hapten is mediated by suppressor cells…”
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Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord by Lankford, Karen L, Arroyo, Edgardo J, Nazimek, Katarzyna, Bryniarski, Krzysztof, Askenase, Philip W, Kocsis, Jeffery D

“…In a previous report we showed that intravenous infusion of bone marrow-derived mesenchymal stem cells (MSCs) improved functional recovery after contusive…”
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Editorial: Extracellular vesicles as potent modulators of immunity by Bryniarski, Krzysztof, Fernández-Messina, Lola, Askenase, Philip W., Nazimek, Katarzyna

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Functions of Exosomes and Microbial Extracellular Vesicles in Allergy and Contact and Delayed-Type Hypersensitivity by Nazimek, Katarzyna, Bryniarski, Krzysztof, Askenase, Philip W

“…Extracellular vesicles, such as exosomes, are newly recognized intercellular conveyors of functional molecular mechanisms. Notably, they transfer RNAs and…”
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Immunobiology of antigen-specific immunoglobulin free light chains in chronic inflammatory diseases by Groot Kormelink, Tom, Askenase, Philip W, Redegeld, Frank A

“…Mast cells are increasingly recognized as critical players in elicitation and maintenance of different inflammatory related disorders, like allergy, autoimmune…”
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A subset of AID-dependent B-1a cells initiates hypersensitivity and pneumococcal pneumonia resistance by Askenase, Phillip W., Bryniarski, Krzysztof, Paliwal, Vipin, Redegeld, Frank, Groot Kormelink, Thomas, Kerfoot, Steven, Hutchinson, Andrew T., van Loveren, Henk, Campos, Regis, Itakura, Atsuko, Majewska-Szczepanik, Monika, Yamamoto, Natsuo, Nazimek, Katarzyn, Szczepanik, Marian, Ptak, Wold

“…We propose that there is a special B‐1a B cell subset (“sB‐1a” cells) that mediates linked processes very early after immunization to initiate cutaneous…”
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Antibodies Enhance the Suppressive Activity of Extracellular Vesicles in Mouse Delayed-Type Hypersensitivity by Nazimek, Katarzyna, Bustos-Morán, Eugenio, Blas-Rus, Noelia, Nowak, Bernadeta, Totoń-Żurańska, Justyna, Seweryn, Michał T., Wołkow, Paweł, Woźnicka, Olga, Szatanek, Rafał, Siedlar, Maciej, Askenase, Philip W., Sánchez-Madrid, Francisco, Bryniarski, Krzysztof

“…Previously, we showed that mouse delayed-type hypersensitivity (DTH) can be antigen-specifically downregulated by suppressor T cell-derived miRNA-150 carried…”
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