Search Results - "Askari, J A"

Identification of a novel heparin-binding site in the alternatively spliced IIICS region of fibronectin: roles of integrins and proteoglycans in cell adhesion to fibronectin splice variants by Mostafavi-Pour, Z., Askari, J.A., Whittard, J.D., Humphries, M.J.

“…The extracellular matrix molecule fibronectin (FN) is a glycoprotein whose major functional property is to support cell adhesion. FN contains at least two…”
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Higher order spin resonances in a 2.1-GeV/c polarized proton beam by Leonova, M A, Askari, J A, Gordon, K N, Krisch, A D, Liu, J, Morozov, V S, Nees, D A, Raymond, R S, Sivers, D W, Wong, V K, Hinterberger, F

“…Spin resonances can depolarize or spin flip a polarized beam. We studied 1st and higher order spin resonances with stored 2.1  GeV/c vertically polarized…”
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Competitive binding of vascular cell adhesion molecule-1 and the HepII/IIICS domain of fibronectin to the integrin alpha 4 beta 1 by Makarem, R, Newham, P, Askari, J A, Green, L J, Clements, J, Edwards, M, Humphries, M J, Mould, A P

“…The integrin receptor alpha 4 beta 1 binds to two different ligands, the extracellular matrix glycoprotein fibronectin and the endothelial cell surface protein…”
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Crystal structure of a heparin- and integrin-binding segment of human fibronectin by Sharma, Amit, Askari, Janet A., Humphries, Martin J., Jones, E.Yvonne, Stuart, David I.

“…The crystal structure of human fibronectin (FN) type III repeats 12–14 reveals the primary heparin‐binding site, a clump of positively charged residues in…”
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Elucidation of the Structural Features of Heparan Sulfate Important for Interaction with the Hep-2 Domain of Fibronectin by Lyon, Malcolm, Rushton, Graham, Askari, Janet A., Humphries, Martin J., Gallagher, John T.

“…The interaction of fibronectin with cell surface heparan sulfate proteoglycans is important biologically in inducing reorganization of the cytoskeleton and the…”
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Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the beta 1 subunit by Mould, A P, Garratt, A N, Askari, J A, Akiyama, S K, Humphries, M J

“…Integrins are the major family of receptors involved in the adhesive interactions of cells with extracellular matrix macromolecules. Although it is known that…”
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Recruitment of a heparan sulfate subunit to the interleukin-1 receptor complex. Regulation by fibronectin attachment by Vallés, S, Tsoi, C, Huang, W Y, Wyllie, D, Carlotti, F, Askari, J A, Humphries, M J, Dower, S K, Qwarnström, E E

“…In this study, we identified an adhesion-regulated subunit of the interleukin-1 (IL-1) receptor complex. Transfection of fibroblasts with an IL-1 receptor-EGFP…”
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Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis by Lock, John G., Jones, Matthew C., Askari, Janet A., Gong, Xiaowei, Oddone, Anna, Olofsson, Helene, Göransson, Sara, Lakadamyali, Melike, Humphries, Martin J., Strömblad, Staffan

“…Adhesion to the extracellular matrix persists during mitosis in most cell types. However, while classical adhesion complexes, such as focal adhesions, do and…”
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Integrin alpha 4 beta 1-mediated melanoma cell adhesion and migration on vascular cell adhesion molecule-1 (VCAM-1) and the alternatively spliced IIICS region of fibronectin by Mould, A P, Askari, J A, Craig, S E, Garratt, A N, Clements, J, Humphries, M J

“…The integrin receptor alpha 4 beta 1 (also known as VLA-4) binds two different ligands, the endothelial cell surface protein vascular cell adhesion molecule-1…”
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Higher Order Spin Resonances in a 2.1 GeV/c Polarized Proton Beam by Leonova, M. A, Askari, J. A, Gordon, K. N, Krisch, A. D, Liu, J, Morozov, V. S, Nees, D. A, Raymond, R. S, Sivers, D. W, Wong, V. K, Hinterberger, F

“…Physical Review Letters 108, 074801 (2012) Spin resonances can depolarize or spin-flip a polarized beam. We studied 1st and higher order spin resonances with…”
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Regulation of integrin alpha 5 beta 1 function by anti-integrin antibodies and divalent cations by Mould, A P, Garratt, A N, Askari, J A, Akiyama, S K, Humphries, M J

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Integrin-Specific Signaling Pathways Controlling Focal Adhesion Formation and Cell Migration by Mostafavi-Pour, Zohreh, Askari, Janet A., Parkinson, Scott J., Parker, Peter J., Tony T. C. Ng, Humphries, Martin J.

“…The fibronectin (FN)-binding integrins α4β1 and α5β1 confer different cell adhesive properties, particularly with respect to focal adhesion formation and…”
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Conformational changes in the integrin beta A domain provide a mechanism for signal transduction via hybrid domain movement by Mould, A Paul, Barton, Stephanie J, Askari, Janet A, McEwan, Paul A, Buckley, Patrick A, Craig, Susan E, Humphries, Martin J

“…The ligand-binding head region of integrin beta subunits contains a von Willebrand factor type A domain (betaA). Ligand binding activity is regulated through…”
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Molecular basis of ligand recognition by integrin alpha 5beta 1. I. Specificity of ligand binding is determined by amino acid sequences in the second and third NH2-terminal repeats of the alpha subunit by Mould, A P, Askari, J A, Humphries, M J

“…The NH(2)-terminal portion (putative ligand-binding domain) of alpha subunits contains 7 homologous repeats, the last 3 or 4 of which possess divalent cation…”
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Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain by Mould, A Paul, Askari, Janet A, Barton, Stephanie, Kline, Adam D, McEwan, Paul A, Craig, Susan E, Humphries, Martin J

“…The ligand-binding region of integrin beta subunits contains a von Willebrand factor type A-domain: an alpha/beta "Rossmann" fold containing a metal…”
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Competitive binding of vascular cell adhesion molecule-1 and the HepII/IIICS domain of fibronectin to the integrin α4β1 by MAKAREM, R, NEWHAM, P, ASKARI, J. A, GREEN, L. J, CLEMENTS, J, EDWARDS, M, HUMPHRIES, M. J, MOULD, A. P

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Monoclonal antibodies identify residues 199‒216 of the integrin α2 vWFA domain as a functionally important region within α2β1 by TUCKWELL, Danny S., SMITH, Lyndsay, KORDA, Michelle, ASKARI, Janet A., SANTOSO, Sentot, BARNES, Michael J., FARNDALE, Richard W., HUMPHRIES, Martin J.

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Structure of an Integrin-Ligand Complex Deduced from Solution X-ray Scattering and Site-directed Mutagenesis by Mould, A.Paul, Symonds, Emlyn J.H., Buckley, Patrick A., Grossmann, J.Günter, McEwan, Paul A., Barton, Stephanie J., Askari, Janet A., Craig, Susan E., Bella, Jordi, Humphries, Martin J.

“…The structural basis of the interaction of integrin heterodimers with their physiological ligands is poorly understood. We have used solution x-ray scattering…”
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Generation of a minimal alpha5beta1 integrin-Fc fragment by Coe, A P, Askari, J A, Kline, A D, Robinson, M K, Kirby, H, Stephens, P E, Humphries, M J

“…The tertiary structure of the integrin heterodimer is currently unknown, although several predictive models have been generated. Detailed structural studies of…”
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Production of recombinant soluble human integrin alpha4beta1 by Clark, K, Newham, P, Burrows, L, Askari, J A, Humphries, M J

“…Integrin alpha4beta1 is a major leukocyte adhesion receptor that is a key target for the development of anti-inflammatory therapeutics. With the dual long-term…”
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