Search Results - "Ashton, Nick"

Extreme glacial cooling likely led to hominin depopulation of Europe in the Early Pleistocene by Margari, Vasiliki, Hodell, David A, Parfitt, Simon A, Ashton, Nick M, Grimalt, Joan O, Kim, Hyuna, Yun, Kyung-Sook, Gibbard, Philip L, Stringer, Chris B, Timmermann, Axel, Tzedakis, Polychronis C

“…The oldest known hominin remains in Europe [~1.5 to ~1.1 million years ago (Ma)] have been recovered from Iberia, where paleoenvironmental reconstructions have…”
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Hominin footprints from early Pleistocene deposits at Happisburgh, UK by Ashton, Nick, Lewis, Simon G, De Groote, Isabelle, Duffy, Sarah M, Bates, Martin, Bates, Richard, Hoare, Peter, Lewis, Mark, Parfitt, Simon A, Peglar, Sylvia, Williams, Craig, Stringer, Chris

“…Investigations at Happisburgh, UK, have revealed the oldest known hominin footprint surface outside Africa at between ca. 1 million and 0.78 million years ago…”
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Impact of maternal intermittent fasting during pregnancy on cardiovascular, metabolic and renal function in adult rat offspring by Alkhalefah, Alaa, Eyre, Heather J, Hussain, Rezwana, Glazier, Jocelyn D, Ashton, Nick

“…Pregnant Muslim women are exempt from fasting during Ramadan; however a majority are reported to fast. The impact of this form of maternal intermittent fasting…”
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Early Pleistocene human occupation at the edge of the boreal zone in northwest Europe by Ashton, Nick M, Parfitt, Simon A, Lewis, Simon G, Abel, Richard L, Coope, G. Russell, Field, Mike H, Gale, Rowena, Hoare, Peter G, Larkin, Nigel R, Lewis, Mark D, Karloukovski, Vassil, Maher, Barbara A, Peglar, Sylvia M, Preece, Richard C, Whittaker, John E, Stringer, Chris B

“…The dispersal of early humans from Africa by 1.75 Myr ago led to a marked expansion of their range, from the island of Flores in the east to the Iberian…”
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A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate by D’Souza, Alicia, Wang, Yanwen, Anderson, Cali, Bucchi, Annalisa, Baruscotti, Mirko, Olieslagers, Servé, Mesirca, Pietro, Johnsen, Anne Berit, Mastitskaya, Svetlana, Ni, Haibo, Zhang, Yu, Black, Nicholas, Cox, Charlotte, Wegner, Sven, Bano-Otalora, Beatriz, Petit, Cheryl, Gill, Eleanor, Logantha, Sunil Jit R.J., Dobrzynski, Halina, Ashton, Nick, Hart, George, Zhang, Rai, Zhang, Henggui, Cartwright, Elizabeth J., Wisloff, Ulrik, Mangoni, Matteo E., da Costa Martins, Paula A., Piggins, Hugh D., DiFrancesco, Dario, Boyett, Mark R.

“…Heart rate follows a diurnal variation, and slow heart rhythms occur primarily at night. The lower heart rate during sleep is assumed to be neural in origin,…”
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Coastal curios? An analysis of ex situ beach finds for mapping new Palaeolithic sites at Happisburgh, UK by Bynoe, Rachel, Ashton, Nick M., Grimmer, Tim, Hoare, Peter, Leonard, Joanne, Lewis, Simon G., Nicholas, Darren, Parfitt, Simon

“…Recent archaeological discoveries from exposures of the Cromer Forest‐bed Formation at Happisburgh, UK, have radically changed interpretations of the nature…”
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Simvastatin causes pulmonary artery relaxation by blocking smooth muscle ROCK and calcium channels: Evidence for an endothelium-independent mechanism by Absi, Mais, Eid, Basma G, Ashton, Nick, Hart, George, Gurney, Alison M

“…Simvastatin reduces pulmonary arterial pressure and right ventricular hypertrophy in animal models of pulmonary arterial hypertension (PAH) and is thought to…”
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Acheulean Diversity in Britain (MIS 15-MIS11): From the Standardization to the Regionalization of Technology by García-Medrano, Paula, Shipton, Ceri, White, Mark, Ashton, Nick

“…The appearance of the Acheulean and the production of new bifacial tools marked a revolution in human behavior. The use of longer and complex operative chains,…”
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The effect of Ramadan fasting during pregnancy on perinatal outcomes: a systematic review and meta-analysis by Glazier, Jocelyn D, Hayes, Dexter J L, Hussain, Sabiha, D'Souza, Stephen W, Whitcombe, Joanne, Heazell, Alexander E P, Ashton, Nick

“…Although exempt, many pregnant Muslim women partake in the daily fast during daylight hours during the month of Ramadan. In other contexts an impoverished diet…”
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FTI-277 inhibits smooth muscle cell calcification by up-regulating PI3K/Akt signaling and inhibiting apoptosis by Ponnusamy, Arvind, Sinha, Smeeta, Hyde, Gareth D, Borland, Samantha J, Taylor, Rebecca F, Pond, Emma, Eyre, Heather J, Inkson, Colette A, Gilmore, Andrew, Ashton, Nick, Kalra, Philip A, Canfield, Ann E

“…Vascular calcification is associated with increased cardiovascular morbidity and mortality in patients with atherosclerosis, diabetes and chronic kidney…”
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X-ray Micro-Computed Tomography: An Emerging Technology to Analyze Vascular Calcification in Animal Models by Borland, Samantha J, Behnsen, Julia, Ashton, Nick, Francis, Sheila E, Brennan, Keith, Sherratt, Michael J, Withers, Philip J, Canfield, Ann E

“…Vascular calcification describes the formation of mineralized tissue within the blood vessel wall, and it is highly associated with increased cardiovascular…”
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Objectifying processes: The use of geometric morphometrics and multivariate analyses on Acheulean tools by García-Medrano, Paula, Maldonado-Garrido, Elías, Ashton, Nick, Ollé, Andreu

“…Nowadays, the fruitful discussion regarding the morphological variability of handaxes during the Middle Pleistocene has reached a decisive moment with the use…”
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Renal function and angiotensin AT1 receptor expression in young rats following intrauterine exposure to a maternal low-protein diet by Sahajpal, Vandana, Ashton, Nick

“…Recent studies have proposed a link between impaired nephrogenesis, decreased activity of the renin-angiotensin system and the onset of hypertension in rats…”
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The urotensin system is up-regulated in the pre-hypertensive spontaneously hypertensive rat by Forty, Ellen J, Ashton, Nick

“…Urotensin II (UII) concentrations are raised both in humans with hypertension and in spontaneously hypertensive rats (SHR). Since the urotensin system acts to…”
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Axl tyrosine kinase protects against tubulo-interstitial apoptosis and progression of renal failure in a murine model of chronic kidney disease and hyperphosphataemia by Hyde, Gareth D, Taylor, Rebecca F, Ashton, Nick, Borland, Samantha J, Wu, Hon Sing Geoffrey, Gilmore, Andrew P, Canfield, Ann E

“…Chronic kidney disease (CKD) is defined as the progressive loss of renal function often involving glomerular, tubulo-interstitial and vascular pathology. CKD…”
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Increased glomerular angiotensin II binding in rats exposed to a maternal low protein diet in utero by Sahajpal, Vandana, Ashton, Nick

“…In the rat, protein restriction during pregnancy increases offspring blood pressure by 20–30 mmHg. We have shown in an earlier study that this is associated…”
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Developmental programming of aortic and renal structure in offspring of rats fed fat-rich diets in pregnancy by Armitage, James A., Lakasing, Lorin, Taylor, Paul D., Balachandran, Aswini A., Jensen, Runa I., Dekou, Vasia, Ashton, Nick, Nyengaard, Jens R., Poston, Lucilla

“…Evidence from human and animal studies suggests that maternal nutrition can induce developmental programming of adult hypertension in offspring. We have…”
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Ex vivo modeling of chemical synergy in prenatal kidney cystogenesis by Anders, Corina, Ashton, Nick, Ranjzad, Parisa, Dilworth, Mark R, Woolf, Adrian S

“…Cyclic adenosine monophosphate (cAMP) drives genetic polycystic kidney disease (PKD) cystogenesis. Yet within certain PKD families, striking differences in…”
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Cultural mosaics, social structure, and identity: The Acheulean threshold in Europe by Ashton, Nick, Davis, Rob

“…The period between 600 and 400 ka is a critical phase for human evolution in Europe. The south and northwest saw a dramatic increase in sites, the spread of…”
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Did our ancestors nearly die out? by Ashton, Nick, Stringer, Chris

“…Genetic analyses suggest an ancient human population crash 900,000 years ago Earth’s climate system began to change during the Middle Pleistocene transition,…”
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