Search Results - "Ashton, J. C."

Mechanisms of synergistic suppression of ALK-positive lung cancer cell growth by the combination of ALK and SHP2 inhibitors by Berry, M. A., Bland, A. R., Ashton, J. C.

“…Lung cancer is a major cause of cancer-related deaths. Alectinib is the first line of treatment for patients with ALK-positive lung cancer, but the survival…”
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Mechanisms of suppression of cell growth by dual inhibition of ALK and MEK in ALK-positive non-small cell lung cancer by Shrestha, N., Nimick, M., Dass, P., Rosengren, R. J., Ashton, J. C.

“…Anaplastic lymphoma kinase (ALK) rearrangement, a key oncogenic driver in a small subset of non-small cell lung cancers, confers sensitivity to ALK tyrosine…”
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Spinal cannabinoid CB2 receptors as a target for neuropathic pain: an investigation using chronic constriction injury by Brownjohn, P.W, Ashton, J.C

“…Abstract Agonists for the cannabinoid CB2 receptor are antinociceptive in several rodent models and several reports have suggested that the target for these…”
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Fetal programming of fat and collagen in porcine skeletal muscles by Karunaratne, J. F., Ashton, C. J., Stickland, N. C.

“…Connective tissue plays a key role in the scaffolding and development of skeletal muscle. Pilot studies carried out in our laboratory have shown that the…”
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The effect of metformin in EML4-ALK+ lung cancer alone and in combination with crizotinib in cell and rodent models by Bland, A.R., Shrestha, N., Bower, R.L., Rosengren, R.J., Ashton, J.C.

“…[Display omitted] Cell based studies have suggested that the diabetes drug metformin may combine with the anaplastic lymphoma kinase receptor (ALK) inhibitor…”
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Inhibition of Mitogen-Activated Protein Kinase Kinase Alone and in Combination with Anaplastic Lymphoma Kinase (ALK) Inhibition Suppresses Tumor Growth in a Mouse Model of ALK-Positive Lung Cancer by Shrestha, N., Bland, A.R., Bower, R.L., Rosengren, R.J., Ashton, J.C.

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The cannabinoid CB2 receptor agonist GW405833 does not ameliorate brain damage induced by hypoxia-ischemia in rats by Rivers-Auty, J.R., Smith, P.F., Ashton, J.C.

“…•The CB2 agonist GW405833 was not neuroprotective in rat hypoxia-ischemia.•Neither pre nor post injury drug administration was protective.•Neither single nor…”
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Expression of the cannabinoid CB2 receptor in the rat cerebellum: An immunohistochemical study by Ashton, John C., Friberg, Deborah, Darlington, Cynthia L., Smith, Paul F.

“…Reports of cannabinoid CB2 receptor protein in the brain have been ambiguous. We therefore tested for CB2 immunoreactivity in the rat brain using…”
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Cannabinoids for the treatment of neuropathic pain: clinical evidence by Ashton, John C, Milligan, Erin D

“…Neuropathic pain is a worldwide epidemic that occurs in 3 to 8% of individuals in industrialized countries and is often refractory to existing treatments…”
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Developmental programming of skeletal muscle phenotype/metabolism by Markham, T. C. W., Latorre, R. M., Lawlor, P. G., Ashton, C. J., McNamara, L. B., Natter, R., Rowlerson, A., Stickland, N. C.

“…Skeletal muscle is a highly dynamic and malleable tissue that is able to adapt to different stimuli placed upon it, both during gestation and after birth,…”
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Immunohistochemical characterisation and localisation of cannabinoid CB1 receptor protein in the rat vestibular nucleus complex and the effects of unilateral vestibular deafferentation by Ashton, John C., Zheng, Yiwen, Liu, Ping, Darlington, Cynthia L., Smith, Paul F.

“…CB1 receptor expression has been reported to be low in the brainstem compared with the forebrain, and low in the vestibular nucleus complex (VNC) compared with…”
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Mitochondrial ultrastructure and apoptotic protein expression in the vestibular nucleus complex following unilateral labyrinthectomy by Ashton, John C., Little, Erica, Muir, Matthew, Smith, Paul F., Darlington, Cynthia L.

“…We hypothesized that peripheral vestibular disorders might affect mitochondria in the vestibular nucleus complex (VNC). We tested this using unilateral…”
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The cannabinoid CB sub(2) receptor agonist GW405833 does not ameliorate brain damage induced by hypoxia-ischemia in rats by Rivers-Auty, J R, Smith, P F, Ashton, J C

“…The cannabinoid CB sub(2) receptor has been under investigation as a potential target for neuroprotection with the suppression of neuroinflammation as the…”
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Facultative prioritization of wing growth in the Welcome Swallow Hirundo neoxena by Ashton, John C., Armstrong, Doug P.

“…Bird species adapted to variable environments tend to have slow lean tissue growth rates and high fat deposition rates, allowing survival during food…”
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The effect of metformin in EML 4 -ALK+ lung cancer alone and in combination with crizotinib in cell and rodent models by Bland, A R, Shrestha, N, Bower, R L, Rosengren, R J, Ashton, J C

“…Cell based studies have suggested that the diabetes drug metformin may combine with the anaplastic lymphoma kinase receptor (ALK) inhibitor crizotinib to…”
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Reliability of immunolabelling in the determination of Huntington's disease neuropathy by Ashton, John C.

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Neuroprotective effect of hydroxypropyl- beta -cyclodextrin in hypoxia-ischemla by Rivers, J R, Maggo, SDS, Ashton, J C

“…Neonatal cerebral ischemic injury is a common and debilitating pathology for which there is currently no known purely pharmacological treatments that are…”
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Blunt Chest Trauma In A Collegiate Football Player: A Case Study by Ashton, J C

“…Background: This case presents a 21-year old collegiate football player who suffered a blunt trauma to his chest while being tackled after a catch. This injury…”
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Erratum to “The cannabinoid CB2 receptor agonist GW405833 does not ameliorate brain damage induced by hypoxia-ischemia in rats” [Neurosci. Lett. 569 (2014) 104–109] by Rivers-Auty, J.R., Smith, P.F., Ashton, J.C.

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Structure of classical trajectories in multidimensional bound molecular systems by Ashton, C. J, Muckerman, J. T

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