Search Results - "Ashton, J."

Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19 by Kanberg, Nelly, Ashton, Nicholas J., Andersson, Lars-Magnus, Yilmaz, Aylin, Lindh, Magnus, Nilsson, Staffan, Price, Richard W., Blennow, Kaj, Zetterberg, Henrik, Gisslén, Magnus

“…OBJECTIVETo test the hypothesis that coronavirus disease 2019 (COVID-19) has an impact on the CNS by measuring plasma biomarkers of CNS injury. METHODSWe…”
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Classification of Paediatric Inflammatory Bowel Disease using Machine Learning by Mossotto, E., Ashton, J. J., Coelho, T., Beattie, R. M., MacArthur, B. D., Ennis, S.

“…Paediatric inflammatory bowel disease (PIBD), comprising Crohn’s disease (CD), ulcerative colitis (UC) and inflammatory bowel disease unclassified (IBDU) is a…”
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Exclusive enteral nutrition in Crohn's disease: Evidence and practicalities by Ashton, James J., Gavin, Joan, Beattie, R. Mark

“…Exclusive enteral nutrition (EEN) is the first line therapy for paediatric Crohn's disease, providing a complete nutritional feed whilst simultaneously…”
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Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology by Ashton, Nicholas J., Pascoal, Tharick A., Karikari, Thomas K., Benedet, Andréa L., Lantero-Rodriguez, Juan, Brinkmalm, Gunnar, Snellman, Anniina, Schöll, Michael, Troakes, Claire, Hye, Abdul, Gauthier, Serge, Vanmechelen, Eugeen, Zetterberg, Henrik, Rosa-Neto, Pedro, Blennow, Kaj

“…The quantification of phosphorylated tau in biofluids, either cerebrospinal fluid (CSF) or plasma, has shown great promise in detecting Alzheimer’s disease…”
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Time course of phosphorylated-tau181 in blood across the Alzheimer's disease spectrum by Moscoso, Alexis, Grothe, Michel J, Ashton, Nicholas J, Karikari, Thomas K, Rodriguez, Juan Lantero, Snellman, Anniina, Suárez-Calvet, Marc, Zetterberg, Henrik, Blennow, Kaj, Schöll, Michael

“…Tau phosphorylated at threonine 181 (p-tau181) measured in blood plasma has recently been proposed as an accessible, scalable, and highly specific biomarker…”
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Microglial activation and tau propagate jointly across Braak stages by Pascoal, Tharick A., Benedet, Andrea L., Ashton, Nicholas J., Kang, Min Su, Therriault, Joseph, Chamoun, Mira, Savard, Melissa, Lussier, Firoza Z., Tissot, Cécile, Karikari, Thomas K., Ottoy, Julie, Mathotaarachchi, Sulantha, Stevenson, Jenna, Massarweh, Gassan, Schöll, Michael, de Leon, Mony J., Soucy, Jean-Paul, Edison, Paul, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, Rosa-Neto, Pedro

“…Compelling experimental evidence suggests that microglial activation is involved in the spread of tau tangles over the neocortex in Alzheimer’s disease (AD)…”
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Steroid‐Responsive Encephalitis in Coronavirus Disease 2019 by Pilotto, Andrea, Odolini, Silvia, Masciocchi, Stefano, Comelli, Agnese, Volonghi, Irene, Gazzina, Stefano, Nocivelli, Sara, Pezzini, Alessandro, Focà, Emanuele, Caruso, Arnaldo, Leonardi, Matilde, Pasolini, Maria P., Gasparotti, Roberto, Castelli, Francesco, Ashton, Nicholas J., Blennow, Kaj, Zetterberg, Henrik, Padovani, Alessandro

“…Coronavirus disease 2019 (COVID‐19) infection has the potential for targeting the central nervous system, and several neurological symptoms have been described…”
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Germinated grains – Sources of bioactive compounds by Donkor, O.N., Stojanovska, L., Ginn, P., Ashton, J., Vasiljevic, T.

“…► Germination manipulated concentrations of bioactive compounds in selected grains. ► Grain and treatment dependant inhibition of α-glucosidase and α-amylase…”
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Editorial: Prediction in Inflammatory Bowel Disease-Do the Answers Lie in Big Clinical Data? by Green, Zachary, Ashton, James J

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The Phosphine Oxide Route toward Lead Halide Perovskite Nanocrystals by Almeida, Guilherme, Ashton, Olivia J, Goldoni, Luca, Maggioni, Daniela, Petralanda, Urko, Mishra, Nimai, Akkerman, Quinten A, Infante, Ivan, Snaith, Henry J, Manna, Liberato

“…We report an amine-free synthesis of lead halide perovskite (LHP) nanocrystals, using trioctylphosphine oxide (TOPO) instead of aliphatic amines, in…”
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Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer’s trial selection and disease monitoring by Ashton, Nicholas J., Janelidze, Shorena, Mattsson-Carlgren, Niklas, Binette, Alexa Pichet, Strandberg, Olof, Brum, Wagner S., Karikari, Thomas K., González-Ortiz, Fernándo, Di Molfetta, Guglielmo, Meda, Francisco J., Jonaitis, Erin M., Koscik, Rebecca Langhough, Cody, Karly, Betthauser, Tobey J., Li, Yan, Vanmechelen, Eugeen, Palmqvist, Sebastian, Stomrud, Erik, Bateman, Randall J., Zetterberg, Henrik, Johnson, Sterling C., Blennow, Kaj, Hansson, Oskar

“…Blood biomarkers indicative of Alzheimer’s disease (AD) pathology are altered in both preclinical and symptomatic stages of the disease. Distinctive biomarkers…”
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GenePy - a score for estimating gene pathogenicity in individuals using next-generation sequencing data by Mossotto, E, Ashton, J J, O'Gorman, L, Pengelly, R J, Beattie, R M, MacArthur, B D, Ennis, S

“…Next-generation sequencing is revolutionising diagnosis and treatment of rare diseases, however its application to understanding common disease aetiology is…”
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Mechanisms of synergistic suppression of ALK-positive lung cancer cell growth by the combination of ALK and SHP2 inhibitors by Berry, M. A., Bland, A. R., Ashton, J. C.

“…Lung cancer is a major cause of cancer-related deaths. Alectinib is the first line of treatment for patients with ALK-positive lung cancer, but the survival…”
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Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility by Karikari, Thomas K., Ashton, Nicholas J., Brinkmalm, Gunnar, Brum, Wagner S., Benedet, Andréa L., Montoliu-Gaya, Laia, Lantero-Rodriguez, Juan, Pascoal, Tharick Ali, Suárez-Calvet, Marc, Rosa-Neto, Pedro, Blennow, Kaj, Zetterberg, Henrik

“…Well-authenticated biomarkers can provide critical insights into the biological basis of Alzheimer disease (AD) to enable timely and accurate diagnosis,…”
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2020 update on the clinical validity of cerebrospinal fluid amyloid, tau, and phospho-tau as biomarkers for Alzheimer’s disease in the context of a structured 5-phase development framework by Leuzy, A., Ashton, N. J., Mattsson-Carlgren, N., Dodich, A., Boccardi, M., Corre, J., Drzezga, A., Nordberg, A., Ossenkoppele, R., Zetterberg, H., Blennow, K., Frisoni, G. B., Garibotto, V., Hansson, O.

“…Purpose In the last decade, the research community has focused on defining reliable biomarkers for the early detection of Alzheimer’s disease (AD) pathology…”
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Plasma biomarkers for Alzheimer’s Disease in relation to neuropathology and cognitive change by Smirnov, Denis S., Ashton, Nicholas J., Blennow, Kaj, Zetterberg, Henrik, Simrén, Joel, Lantero-Rodriguez, Juan, Karikari, Thomas K., Hiniker, Annie, Rissman, Robert A., Salmon, David P., Galasko, Douglas

“…Plasma biomarkers related to amyloid, tau, and neurodegeneration (ATN) show great promise for identifying these pathological features of Alzheimer’s Disease…”
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Interactions with conspecific outsiders as drivers of cognitive evolution by Ashton, Benjamin J., Kennedy, Patrick, Radford, Andrew N.

“…The social intelligence hypothesis (SIH) posits that within-group interactions drive cognitive evolution, but it has received equivocal support. We argue the…”
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The validation status of blood biomarkers of amyloid and phospho-tau assessed with the 5-phase development framework for AD biomarkers by Ashton, N. J., Leuzy, A., Karikari, T. K., Mattsson-Carlgren, N., Dodich, A., Boccardi, M., Corre, J., Drzezga, A., Nordberg, A., Ossenkoppele, R., Zetterberg, H., Blennow, K., Frisoni, G. B., Garibotto, V., Hansson, O.

“…Purpose The development of blood biomarkers that reflect Alzheimer’s disease (AD) pathophysiology (phosphorylated tau and amyloid-β) has offered potential as…”
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Facile Synthesis of Stable and Highly Luminescent Methylammonium Lead Halide Nanocrystals for Efficient Light Emitting Devices by Hassan, Yasser, Ashton, Olivia J, Park, Jong Hyun, Li, Guangru, Sakai, Nobuya, Wenger, Bernard, Haghighirad, Amir-Abbas, Noel, Nakita K, Song, Myoung Hoon, Lee, Bo Ram, Friend, Richard H, Snaith, Henry J

“…Metal halide perovskites are promising candidates for use in light emitting diodes (LEDs), due to their potential for color tunable and high luminescence…”
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The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease by Simrén, Joel, Leuzy, Antoine, Karikari, Thomas K., Hye, Abdul, Benedet, Andréa Lessa, Lantero‐Rodriguez, Juan, Mattsson‐Carlgren, Niklas, Schöll, Michael, Mecocci, Patrizia, Vellas, Bruno, Tsolaki, Magda, Kloszewska, Iwona, Soininen, Hilkka, Lovestone, Simon, Aarsland, Dag, Hansson, Oskar, Rosa‐Neto, Pedro, Westman, Eric, Blennow, Kaj, Zetterberg, Henrik, Ashton, Nicholas J.

“…Introduction This study investigated the diagnostic and disease‐monitoring potential of plasma biomarkers in mild cognitive impairment (MCI) and Alzheimer's…”
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