The modelling and application of pulsed laser photoacoustics for the detection of body analytes
In this thesis, the experimental and theoretical approach that has been taken in applying the technique of pulsed laser photoacoustics to the detection of body analytes is discussed.The history of the subject and the need for non-invasive measurements are discussed and the basic theory for pulsed la...
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| Format: | Dissertation |
| Language: | English |
| Published: |
ProQuest Dissertations & Theses
01-01-1999
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| Online Access: | Get full text |
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| Summary: | In this thesis, the experimental and theoretical approach that has been taken in applying the technique of pulsed laser photoacoustics to the detection of body analytes is discussed.The history of the subject and the need for non-invasive measurements are discussed and the basic theory for pulsed laser photoacoustic generation is presented. Various analysis techniques for the characterisation of the temporal photoacoustic signal are considered, including the application of Wavelet analysis. The instrumentation requirements for this type of measurement are described and the photoacoustic spectra of key body analytes are reported.Experimental studies on in vitro glucose solutions have shown a high linear correlation, with an R2 value of 0.995, with glucose concentration within the physiological range at a wavelength of 1700nm. Physiological concentrations of salt and albumin have been shown to affect the baseline and not the slope of this correlation. Photoacoustic spectra of glucose, salt, cholesterol and albumin, within the wavelength range 800nm - 1200nm, have been obtained and show different spectral features.The development of a practical computer model to predict the photoacoustic signal under changing experimental conditions is also described within this thesis. The resulting model has been applied to investigate the influence of changes in the experimental system on the photoacoustic signal. The model has also been compared to experimental results where good agreement was obtained.These studies show the promise and feasibility of pulsed laser photoacoustics as a potential method for the non-invasive detection of blood glucose. |
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