Search Results - "Ashraf, Naila"

Altered retinal structure and function in Spinocerebellar ataxia type 3 by Toulis, Vasileios, Casaroli-Marano, Ricardo, Camós-Carreras, Anna, Figueras-Roca, Marc, Sánchez-Dalmau, Bernardo, Muñoz, Esteban, Ashraf, Naila S., Ferreira, Ana F., Khan, Naheed, Marfany, Gemma, Costa, Maria do Carmo

“…Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disorder caused by expansion of a polyglutamine (polyQ)-encoding CAG repeat in…”
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Druggable genome screen identifies new regulators of the abundance and toxicity of ATXN3, the Spinocerebellar Ataxia type 3 disease protein by Ashraf, Naila S., Sutton, Joanna R., Yang, Yemen, Ranxhi, Bedri, Libohova, Kozeta, Shaw, Emily D., Barget, Anna J., Todi, Sokol V., Paulson, Henry L., Costa, Maria do Carmo

“…Spinocerebellar Ataxia type 3 (SCA3, also known as Machado-Joseph disease) is a neurodegenerative disorder caused by a CAG repeat expansion encoding an…”
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Toward RNAi Therapy for the Polyglutamine Disease Machado–Joseph Disease by do Carmo Costa, Maria, Luna-Cancalon, Katiuska, Fischer, Svetlana, Ashraf, Naila S, Ouyang, Michelle, Dharia, Rahil M, Martin-Fishman, Lucas, Yang, Yemen, Shakkottai, Vikram G, Davidson, Beverly L, Rodríguez-Lebrón, Edgardo, Paulson, Henry L

“…Machado–Joseph disease (MJD) is a dominantly inherited ataxia caused by a polyglutamine-coding expansion in the ATXN3 gene. Suppressing expression of the toxic…”
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In Vivo Molecular Signatures of Cerebellar Pathology in Spinocerebellar Ataxia Type 3 by Costa, Maria do Carmo, Radzwion, Maria, McLoughlin, Hayley S., Ashraf, Naila S., Fischer, Svetlana, Shakkottai, Vikram G., Maciel, Patrícia, Paulson, Henry L., Öz, Gülin

“…Background No treatment exists for the most common dominantly inherited ataxia Machado‐Joseph disease, or spinocerebellar ataxia type 3 (SCA3). Successful…”
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Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly by Sharkey, Lisa M., Safren, Nathaniel, Pithadia, Amit S., Gerson, Julia E., Dulchavsky, Mark, Fischer, Svetlana, Patel, Ronak, Lantis, Gabrielle, Ashraf, Naila, Kim, John H., Meliki, Alia, Minakawa, Eiko N., Barmada, Sami J., Ivanova, Magdalena I., Paulson, Henry L.

“…UBQLN2 is one of a family of proteins implicated in ubiquitin-dependent protein quality control and integrally tied to human neurodegenerative disease. Whereas…”
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Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3 by Costa, Maria do Carmo, Ashraf, Naila S, Fischer, Svetlana, Yang, Yemen, Schapka, Emily, Joshi, Gnanada, McQuade, Thomas J, Dharia, Rahil M, Dulchavsky, Mark, Ouyang, Michelle, Cook, David, Sun, Duxin, Larsen, Martha J, Gestwicki, Jason E, Todi, Sokol V, Ivanova, Magdalena I, Paulson, Henry L

“…No disease-modifying treatment exists for the fatal neurodegenerative polyglutamine disease known both as Machado-Joseph disease and spinocerebellar ataxia…”
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Blood levels of neurofilament light are associated with disease progression in a mouse model of spinocerebellar ataxia type 3 by Mengel, David, Wellik, Isabel G, Schuster, Kristen H, Jarrah, Sabrina I, Wacker, Madeleine, Ashraf, Naila S, Öz, Gülin, Synofzik, Matthis, Costa, Maria do Carmo, McLoughlin, Hayley S

“…Increased neurofilament light (NfL; NEFL) protein in biofluids is reflective of neurodegeneration and has gained interest as a biomarker across…”
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The Ubiquitin-conjugating Enzyme (E2) Ube2w Ubiquitinates the N Terminus of Substrates by Scaglione, Kenneth Matthew, Basrur, Venkatesha, Ashraf, Naila S., Konen, John R., Elenitoba-Johnson, Kojo S.J., Todi, Sokol V., Paulson, Henry L.

“…Attachment of ubiquitin to substrate is typically thought to occur via formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and…”
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United States County-level COVID-19 Death Rates and Case Fatality Rates Vary by Region and Urban Status by Ahmed, Rashid, Williamson, Mark, Hamid, Muhammad Akhter, Ashraf, Naila

“…COVID-19 is a global pandemic with uncertain death rates. We examined county-level population morality rates (per 100,000) and case fatality rates by US region…”
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Citalopram Reduces Aggregation of ATXN3 in a YAC Transgenic Mouse Model of Machado-Joseph Disease by Ashraf, Naila S., Duarte-Silva, Sara, Shaw, Emily D., Maciel, Patrícia, Paulson, Henry L., Teixeira-Castro, Andreia, Costa, Maria do Carmo

“…Machado-Joseph disease, also known as spinocerebellar ataxia type 3, is a fatal polyglutamine disease with no disease-modifying treatment. The selective…”
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Tissue-Specific Vulnerability to Apoptosis in Machado-Joseph Disease by Ferreira, Ana F, Raposo, Mafalda, Shaw, Emily D, Ashraf, Naila S, Medeiros, Filipa, Brilhante, Maria de Fátima, Perkins, Matthew, Vasconcelos, João, Kay, Teresa, Costa, Maria do Carmo, Lima, Manuela

“…Machado-Joseph disease (MJD) is a dominant neurodegenerative disease caused by an expanded CAG repeat in the gene encoding the ataxin-3 protein. Several…”
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A New Overpotential — Capacitance Mechanism for H2 Electrode by Cheng, K., Ashraf, Naila, Wei, Glenn

“…The H2 electrode is commonly assumed to be a half-cell, 2 H+ 2e == H2, andexplained by the Nernst equation. We cannot assume that the H+ is easily reduced to…”
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Volumetric behavior of nitroimidazoles in binary solvent mixtures by Naseem, Bushra, Ashraf, Naila

“…In the present study density and ultrasonic velocity have been measured at different temperatures for antibiotics Ronidazole (RNZ) and Dimetridazole (DMZ) in…”
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95. Effect of a pediatric mock code on resuscitation skills and team performance: an in situ simulation experience over three years by Hazwani, Tarek, Ashraf, Naila, Hasan, Zahra, Antar, Mohannad, Kazzaz, Yasser, Alali, Hamza

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INVESTIGATING THE ROLE OF UBIQUILIN2 IN AGE-RELATED NEURODEGENERATION by Sharkey, Lisa M., Safren, Nate, Pithadia, Amit, Gerson, Julia E., Dulchavsky, Mark E., Fischer, Svetlana, Patel, Ronak, Lantis, Gabrielle, Ashraf, Naila, Barmada, Sami, Ivanova, Magdalena, Paulson, Henry L.

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P3‐152: INVESTIGATING THE ROLE OF UBIQUILIN2 IN AGE‐RELATED NEURODEGENERATION by Sharkey, Lisa M., Safren, Nate, Pithadia, Amit, Gerson, Julia E., Dulchavsky, Mark E., Fischer, Svetlana, Patel, Ronak, Lantis, Gabrielle, Ashraf, Naila, Barmada, Sami, Ivanova, Magdalena, Paulson, Henry L.

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Energy outlook in Pakistan by Amber, Khuram Pervez, Ashraf, Naila

“…Pakistan is facing a severe energy crisis of its history due to increase in the energy demand and lack of investment in mobilizing its energy resources. This…”
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Heterogeneous electron transfer rate constants for the second reduction process of some dinitroaromatics by MOHAMMAD, M, KHAN, A. Y, QURESHI, R, ASHRAF, N, BEGUM, W

“…Standard heterogeneous electron transfer rate constants k 0 for the second reduction process of 1,2-, 1,3- and 1,4-dinitrobenzenes were evaluated by the…”
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