Search Results - "Ashpole, Nicole M"

Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin Derivatives by Tandon, Ritesh, Sharp, Joshua S, Zhang, Fuming, Pomin, Vitor H, Ashpole, Nicole M, Mitra, Dipanwita, McCandless, Martin G, Jin, Weihua, Liu, Hao, Sharma, Poonam, Linhardt, Robert J

“…Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has caused a pandemic of historic proportions and continues to spread globally, with…”
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Growth hormone, insulin-like growth factor-1 and the aging brain by Ashpole, Nicole M., Sanders, Jessica E., Hodges, Erik L., Yan, Han, Sonntag, William E.

“…Growth hormone (GH) and insulin-like growth factor (IGF)-1 regulate the development and function of cells throughout the body. Several clinical diseases that…”
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Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase by Toth, Peter, Tarantini, Stefano, Tucsek, Zsuzsanna, Ashpole, Nicole M, Sosnowska, Danuta, Gautam, Tripti, Ballabh, Praveen, Koller, Akos, Sonntag, William E, Csiszar, Anna, Ungvari, Zoltan

“…Moment-to-moment adjustment of cerebral blood flow (CBF) to neuronal activity via neurovascular coupling is essential for the maintenance of normal neuronal…”
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IGF‐1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging by Toth, Peter, Tarantini, Stefano, Ashpole, Nicole M., Tucsek, Zsuzsanna, Milne, Ginger L., Valcarcel‐Ares, Noa M., Menyhart, Akos, Farkas, Eszter, Sonntag, William E., Csiszar, Anna, Ungvari, Zoltan

“…Summary Aging is associated with marked deficiency in circulating IGF‐1, which has been shown to contribute to age‐related cognitive decline. Impairment of…”
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Small molecule inhibitors of PSD95-nNOS protein–protein interactions as novel analgesics by Lee, Wan-Hung, Xu, Zhili, Ashpole, Nicole M., Hudmon, Andy, Kulkarni, Pushkar M., Thakur, Ganesh A., Lai, Yvonne Y., Hohmann, Andrea G.

“…Aberrant increases in NMDA receptor (NMDAR) signaling contributes to central nervous system sensitization and chronic pain by activating neuronal nitric oxide…”
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Aging Impairs Myogenic Adaptation to Pulsatile Pressure in Mouse Cerebral Arteries by Springo, Zsolt, Toth, Peter, Tarantini, Stefano, Ashpole, Nicole M, Tucsek, Zsuzsanna, Sonntag, William E, Csiszar, Anna, Koller, Akos, Ungvari, Zoltan I

“…Stability of myogenic tone in middle cerebral arteries (MCA) is essential for adequate control over penetration of pressure waves into the distal portion of…”
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Insulin-Like Growth Factor-1 Differentially Modulates Glutamate-Induced Toxicity and Stress in Cells of the Neurogliovascular Unit by Hayes, Cellas A., Ashmore, Brandon G., Vijayasankar, Akshaya, Marshall, Jessica P., Ashpole, Nicole M.

“…The age-related reduction in circulating levels of insulin-like growth factor-1 (IGF-1) is associated with increased risk of stroke and neurodegenerative…”
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CaMKII in cerebral ischemia by Coultrap, Steven J, Vest, Rebekah S, Ashpole, Nicole M, Hudmon, Andy, Bayer, K Ulrich

“…Ischemic insults on neurons trigger excessive, pathological glutamate release that causes Ca^2＋ overload resulting in neuronal cell death （excitotoxicity）. The…”
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IGF‐1 Regulates Vertebral Bone Aging Through Sex‐Specific and Time‐Dependent Mechanisms by Ashpole, Nicole M, Herron, Jacquelyn C, Mitschelen, Matthew C, Farley, Julie A, Logan, Sreemathi, Yan, Han, Ungvari, Zoltan, Hodges, Erik L, Csiszar, Anna, Ikeno, Yuji, Humphrey, Mary Beth, Sonntag, William E

“…ABSTRACT Advanced aging is associated with increased risk of bone fracture, especially within the vertebrae, which exhibit significant reductions in trabecular…”
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Loss of Calcium/Calmodulin-dependent Protein Kinase II Activity in Cortical Astrocytes Decreases Glutamate Uptake and Induces Neurotoxic Release of ATP by Ashpole, Nicole M., Chawla, Aarti R., Martin, Matthew P., Brustovetsky, Tatiana, Brustovetsky, Nickolay, Hudmon, Andy

“…The extent of calcium/calmodulin-dependent protein kinase II (CaMKII) inactivation in the brain after ischemia correlates with the extent of damage. We have…”
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4- O -Methylhonokiol Influences Normal Cardiovascular Development in Medaka Embryo by Singha, Santu K, Muhammad, Ilias, Ibrahim, Mohamed Ali, Wang, Mei, Ashpole, Nicole M, Shariat-Madar, Zia

“…Although 4- -Methylhonokiol (MH) effects on neuronal and immune cells have been established, it is still unclear whether MH can cause a change in the structure…”
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Target-Specific Support Vector Machine Scoring in Structure-Based Virtual Screening: Computational Validation, In Vitro Testing in Kinases, and Effects on Lung Cancer Cell Proliferation by Li, Liwei, Khanna, May, Jo, Inha, Wang, Fang, Ashpole, Nicole M, Hudmon, Andy, Meroueh, Samy O

“…We assess the performance of our previously reported structure-based support vector machine target-specific scoring function across 41 targets, 40 among them…”
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Aging circadian rhythms and cannabinoids by Hodges, Erik L., Ashpole, Nicole M.

“…Numerous aspects of mammalian physiology exhibit cyclic daily patterns known as circadian rhythms. However, studies in aged humans and animals indicate that…”
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Preclinical and clinical evidence of IGF-1 as a prognostic marker and acute intervention with ischemic stroke by Hayes, Cellas A, Valcarcel-Ares, M Noa, Ashpole, Nicole M

“…Ischemic strokes are highly prevalent in the elderly population and are a leading cause of mortality and morbidity worldwide. The risk of ischemic stroke…”
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Excitotoxic neuroprotection and vulnerability with CaMKII inhibition by Ashpole, Nicole M., Hudmon, Andy

“…Aberrant calcium signaling is a common feature of ischemia and multiple neurodegenerative diseases. While activation of calcium–calmodulin (CaM)-dependent…”
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Loss of insulin‐like growth factor‐1 signaling in astrocytes disrupts glutamate handling by Prabhu, Disha, Khan, Sariya M., Blackburn, Katherine, Marshall, Jessica P., Ashpole, Nicole M.

“…Insulin‐like Growth Factor‐1 (IGF‐1) has been studied extensively for its ability to promote neuronal growth and excitability. Declining levels of IGF‐1 have…”
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Cannabis constituents reduce seizure behavior in chemically-induced and scn1a-mutant zebrafish by Thornton, Cammi, Dickson, Kennedy E., Carty, Dennis R., Ashpole, Nicole M., Willett, Kristine L.

“…Current antiepileptic drugs (AEDs) are undesirable for many reasons including the inability to reduce seizures in certain types of epilepsy, such as Dravet…”
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Insulin-like growth factor-1 and cognitive health: Exploring cellular, preclinical, and clinical dimensions by Hayes, Cellas A., Wilson, Destiny, De Leon, Miguel A., Mustapha, Mubarak Jolayemi, Morales, Sharon, Odden, Michelle C., Ashpole, Nicole M.

“…•Aging is the primary risk factor for cognitive impairment and dementia.•Insulin-like growth factor 1 (IGF-1) declines throughout lifespan.•In preclinical…”
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Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) Inhibition Induces Neurotoxicity via Dysregulation of Glutamate/Calcium Signaling and Hyperexcitability by Ashpole, Nicole M., Song, Weihua, Brustovetsky, Tatiana, Engleman, Eric A., Brustovetsky, Nickolay, Cummins, Theodore R., Hudmon, Andy

“…Aberrant glutamate and calcium signalings are neurotoxic to specific neuronal populations. Calcium/calmodulin-dependent kinase II (CaMKII), a multifunctional…”
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Astrocyte senescence contributes to cognitive decline by Csipo, Tamas, Lipecz, Agnes, Ashpole, Nicole M., Balasubramanian, Priya, Tarantini, Stefano

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