Grafting of a novel gold(III) complex on nanoporous MCM-41 and evaluation of its toxicity in Saccharomyces cerevisiae

The goal of this research was to investigate the potential of newly synthesized gold complex trichloro(2,4,6-trimethylpyridine)Au(III) as an anticancer agent. The gold(III) complex was synthesized and grafted on nanoporous silica, MCM-41, to produce AuCl(3)@PF-MCM- 41 (AuCl(3) grafted on pyridine-fu...

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Bibliographic Details
Published in:	International journal of nanomedicine Vol. 6; no. default; pp. 3251 - 3257
Main Authors:	Fazaeli, Yousef, Amini, Mostafa M, Ashourion, Hamed, Heydari, Homayoun, Majdabadi, Abbas, Jalilian, Amir Reza, Abolmaali, Shamsozoha
Format:	Journal Article
Language:	English
Published:	New Zealand Dove Press 01-01-2011 Dove Medical Press
Subjects:	Analgesics - administration & dosage Analgesics - chemical synthesis anticancer agent Au(III) Cell Survival - drug effects Gold - administration & dosage Humans Materials Testing MCM-41 Nanocapsules - administration & dosage Nanocapsules - chemistry Original Research Porosity Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - drug effects Silicon Dioxide - administration & dosage Silicon Dioxide - chemical synthesis trichloro(2,4,6-trimethylpyridine)Au(III) trichloro(2,4,6-trimethylpyridine)Au(III) MCM-41 Saccharomyces cerevisiae Au(III) anticancer agent
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Summary:	The goal of this research was to investigate the potential of newly synthesized gold complex trichloro(2,4,6-trimethylpyridine)Au(III) as an anticancer agent. The gold(III) complex was synthesized and grafted on nanoporous silica, MCM-41, to produce AuCl(3)@PF-MCM- 41 (AuCl(3) grafted on pyridine-functionalized MCM-41). The toxicity of trichloro(2,4,6- trimethylpyridine)Au(III) and AuCl(3)@PF-MCM-41 in Saccharomyces cerevisiae (as a model system) was studied. The gold(III) complex showed a mid cytotoxic effect on yeast viability. Using the drug delivery system, nanoporous MCM-41, the gold(III) complex became a strong inhibitor for growth of yeast cells at a very low concentration. Furthermore, the animal tests revealed a high uptake of AuCl(3)@PF-MCM-41 in tumor cells. The stability of the compound was confirmed in human serum.
ISSN:	1178-2013 1176-9114 1178-2013
DOI:	10.2147/IJN.S25449