Gut microbiota-gonadal axis: the impact of gut microbiota on reproductive functions

Gut microbiota-gonadal axis: the impact of gut microbiota on reproductive functions

The influence of gut microbiota on physiological processes is rapidly gaining attention globally. Despite being under-studied, there are available data demonstrating a gut microbiota-gonadal cross-talk, and the importance of this axis in reproduction. This study reviews the impacts of gut microbiota...

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Bibliographic Details
Published in:Frontiers in immunology Vol. 15; p. 1346035
Main Authors: Ashonibare, Victory J, Akorede, Bolaji A, Ashonibare, Precious J, Akhigbe, Tunmise M, Akhigbe, Roland Eghoghosoa
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 28-02-2024
Subjects:
Animals
Cytokines
Female
Gastrointestinal Microbiome
gut microbiota
Humans
Immune System
Immunology
infertility
inflammation
insulin resistance
Male
microbiome
Microbiota
oxidative stress
Reproduction
infertility
inflammation
insulin resistance
microbiome
gut microbiota
oxidative stress
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Summary:The influence of gut microbiota on physiological processes is rapidly gaining attention globally. Despite being under-studied, there are available data demonstrating a gut microbiota-gonadal cross-talk, and the importance of this axis in reproduction. This study reviews the impacts of gut microbiota on reproduction. In addition, the possible mechanisms by which gut microbiota modulates male and female reproduction are presented. Databases, including Embase, Google scholar, Pubmed/Medline, Scopus, and Web of Science, were explored using relevant key words. Findings showed that gut microbiota promotes gonadal functions by modulating the circulating levels of steroid sex hormones, insulin sensitivity, immune system, and gonadal microbiota. Gut microbiota also alters ROS generation and the activation of cytokine accumulation. In conclusion, available data demonstrate the existence of a gut microbiota-gonadal axis, and role of this axis on gonadal functions. However, majority of the data were compelling evidences from animal studies with a great dearth of human data. Therefore, human studies validating the reports of experimental studies using animal models are important.
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Reviewed by: Pradeep Kumar Shukla, University of Tennessee Health Science Center (UTHSC), United States
Edited by: Darong Yang, St. Jude Children’s Research Hospital, United States
Christoph Reinhardt, Johannes Gutenberg University Mainz, Germany
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2024.1346035