Search Results - "Ashmus, Roger A"

Bicyclic Picomolar OGA Inhibitors Enable Chemoproteomic Mapping of Its Endogenous Post-translational Modifications by González-Cuesta, Manuel, Sidhu, Peter, Ashmus, Roger A, Males, Alexandra, Proceviat, Cameron, Madden, Zarina, Rogalski, Jason C, Busmann, Jil A, Foster, Leonard J, García Fernández, José M, Davies, Gideon J, Ortiz Mellet, Carmen, Vocadlo, David J

“…Owing to its roles in human health and disease, the modification of nuclear, cytoplasmic, and mitochondrial proteins with O-linked N-acetylglucosamine residues…”
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Biological roles of the O-methyl phosphoramidate capsule modification in Campylobacter jejuni by van Alphen, Lieke B, Wenzel, Cory Q, Richards, Michele R, Fodor, Christopher, Ashmus, Roger A, Stahl, Martin, Karlyshev, Andrey V, Wren, Brendan W, Stintzi, Alain, Miller, William G, Lowary, Todd L, Szymanski, Christine M

“…Campylobacter jejuni is a major cause of bacterial gastroenteritis worldwide, and the capsular polysaccharide (CPS) of this organism is required for…”
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A Branched and Double Alpha-Gal-Bearing Synthetic Neoglycoprotein as a Biomarker for Chagas Disease by Montoya, Alba L, Carvajal, Elisa G, Ortega-Rodriguez, Uriel, Estevao, Igor L, Ashmus, Roger A, Jankuru, Sohan R, Portillo, Susana, Ellis, Cameron C, Knight, Colin D, Alonso-Padilla, Julio, Izquierdo, Luis, Pinazo, Maria-Jesus, Gascon, Joaquim, Suarez, Veronica, Watts, Douglas M, Malo, Iliana R, Ramsey, Janine M, Alarcón De Noya, Belkisyolé, Noya, Oscar, Almeida, Igor C, Michael, Katja

“…Chagas disease (CD) is caused by the parasite and affects 6-7 million people worldwide. The diagnosis is still challenging, due to extensive parasite diversity…”
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sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease by González-Cuesta, Manuel, Herrera-González, Irene, García-Moreno, M. Isabel, Ashmus, Roger A., Vocadlo, David J., García Fernández, José M., Nanba, Eiji, Higaki, Katsumi, Ortiz Mellet, Carmen

“…The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below 10% of normal, due to mutations that…”
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Reversed Immunoglycomics Identifies α-Galactosyl-Bearing Glycotopes Specific for Leishmania major Infection by Montoya, Alba L., Austin, Victoria M., Portillo, Susana, Vinales, Irodiel, Ashmus, Roger A., Estevao, Igor, Jankuru, Sohan R., Alraey, Yasser, Al-Salem, Waleed S., Acosta-Serrano, Álvaro, Almeida, Igor C., Michael, Katja

“…All healthy humans have high levels of natural anti-α-galactosyl (α-Gal) antibodies (elicited by yet uncharacterized glycotopes), which may play important…”
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Enhancing glycan isomer separations with metal ions and positive and negative polarity ion mobility spectrometry-mass spectrometry analyses by Zheng, Xueyun, Zhang, Xing, Schocker, Nathaniel S., Renslow, Ryan S., Orton, Daniel J., Khamsi, Jamal, Ashmus, Roger A., Almeida, Igor C., Tang, Keqi, Costello, Catherine E., Smith, Richard D., Michael, Katja, Baker, Erin S.

“…Glycomics has become an increasingly important field of research since glycans play critical roles in biology processes ranging from molecular recognition and…”
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A metabolic inhibitor blocks cellular fucosylation and enables production of afucosylated antibodies by Gilormini, Pierre-André, Thota, V Narasimharao, Fers-Lidou, Anthony, Ashmus, Roger A, Nodwell, Matthew, Brockerman, Jacob, Kuo, Chu-Wei, Wang, Yang, Gray, Taylor E, Nitin, McDonagh, Anthony W, Guu, Shih-Yun, Ertunc, Nursah, Yeo, Dominick, Zandberg, Wesley F, Khoo, Kay-Hooi, Britton, Robert, Vocadlo, David J

“…The fucosylation of glycoproteins regulates diverse physiological processes. Inhibitors that can control cellular levels of protein fucosylation have…”
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Quantifying lysosomal glycosidase activity within cells using bis-acetal substrates by Cecioni, Samy, Ashmus, Roger A., Gilormini, Pierre-André, Zhu, Sha, Chen, Xi, Shan, Xiaoyang, Gros, Christina, Deen, Matthew C., Wang, Yang, Britton, Robert, Vocadlo, David J.

“…Understanding the function and regulation of enzymes within their physiologically relevant milieu requires quality tools that report on their cellular…”
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Synthesis of Carbohydrate Methyl Phosphoramidates by Ashmus, Roger A., Lowary, Todd L.

“…A two-step route for introducing methyl phosphoramidate moieties onto carbohydrates is reported. The approach uses methyl pivolyl H-phosphonate as the…”
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Potent and Selective Cell‐Active Iminosugar Inhibitors of Human α‐N‐Acetylgalactosaminidase (α‐NAGAL) by Ashmus, Roger A., Wang, Yang, González‐Cuesta, Manuel, King, Dustin T., Tiet, Ben, Chen, Xi, Zhu, Yanping, Kirk, Bryce, García Fernandez, José M., Ortiz Mellet, Carmen, Britton, Robert, Vocadlo, David J.

“…Glycoside hydrolases (GHs) are a class of enzymes with emerging roles in a range of disease. Selective GH inhibitors are sought to better understand their…”
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Fluorescence-Quenched Substrates for Quantitative Live Cell Imaging of Glucocerebrosidase Activity by Ashmus, Roger A, Shen, David L, Vocadlo, David J

“…Glucocerebrosidase (GCase) is a lysosomal glycoside hydrolase that cleaves the glycolipid glucosylceramide (GlcCer). Deficiencies of this enzyme lead to…”
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Synthesis of Uronic Acid 1‐Azasugars as Putative Inhibitors of α‐Iduronidase, β‐Glucuronidase and Heparanase by Doherty, Gareth G., Ler, Geraldine Jia Ming, Wimmer, Norbert, Bernhardt, Paul V., Ashmus, Roger A., Vocadlo, David J., Armstrong, Zachary, Davies, Gideon J., Maccarana, Marco, Li, Jin‐ping, Kayal, Yasmin, Ferro, Vito

“…1‐Azasugar analogues of l‐iduronic acid (l‐IdoA) and d‐glucuronic acid (d‐GlcA) and their corresponding enantiomers have been synthesized as potential…”
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sp 2 -Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease by González-Cuesta, Manuel, Herrera-González, Irene, García-Moreno, M Isabel, Ashmus, Roger A, Vocadlo, David J, García Fernández, José M, Nanba, Eiji, Higaki, Katsumi, Ortiz Mellet, Carmen

“…The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below 10% of normal, due to mutations that…”
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Rational design of cell active C2-modified DGJ analogues for the inhibition of human α-galactosidase A (GALA) by Ashmus, Roger A, Wang, Yang, González-Cuesta, Manuel, King, Dustin T, Tiet, Ben, Gilormini, Pierre-André, García Fernández, José M, Ortiz Mellet, Carmen, Britton, Robert, Vocadlo, David J

“…We report the rational design and synthesis of C2-modified DGJ analogues to improve the selective inhibition of human GALA over other glycosidases. We prepare…”
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An Oxidation-Amidation Approach for the Synthesis of Glycuronamides by Lin, Sicheng, Ashmus, Roger A., Lowary, Todd L.

“…A route for the synthesis of glycuronamides via the intermediacy of 6‐S‐tolyl‐substituted glycosides and uronic acid thioesters, is reported. The route, which…”
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Anti-α-Gal antibodies detected by novel neoglycoproteins as a diagnostic tool for Old World cutaneous leishmaniasis caused by Leishmania major by Subramaniam, Krishanthi S, Austin, Victoria, Schocker, Nathaniel S, Montoya, Alba L, Anderson, Matthew S, Ashmus, Roger A, Mesri, Mina, Al-Salem, Waleed, Almeida, Igor C, Michael, Katja, Acosta-Serrano, Alvaro

“…Outbreaks of Old World cutaneous leishmaniasis (CL) have significantly increased due to the conflicts in the Middle East, with most of the cases occurring in…”
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De Novo Asymmetric Synthesis of a 6‑O‑Methyl‑d-glycero-l-gluco-heptopyranose-Derived Thioglycoside for the Preparation of Campylobacter jejuni NCTC11168 Capsular Polysaccharide Fragments by Ashmus, Roger A, Jayasuriya, Anushka B, Lim, Ying-Jie, O’Doherty, George A, Lowary, Todd L

“…An enantioselective de novo synthesis of a thioglycoside derivative of the 6-O-methyl-d-glycero-l-gluco-heptopyranose residue found in the Campylobacter jejuni…”
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Potential use of synthetic α-galactosyl-containing glycotopes of the parasite Trypanosoma cruzi as diagnostic antigens for Chagas disease by Ashmus, Roger A, Schocker, Nathaniel S, Cordero-Mendoza, Yanira, Marques, Alexandre F, Monroy, Erika Y, Pardo, Andrew, Izquierdo, Luis, Gállego, Montserrat, Gascon, Joaquim, Almeida, Igor C, Michael, Katja

“…A synthetic glycoarray containing non-reducing α-galactopyranosyl moieties related to mucin O-glycans of the parasite Trypanosoma cruzi was evaluated by a…”
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A high-yielding synthesis of allyl glycosides from peracetylated glycosyl donors by Khamsi, Jamal, Ashmus, Roger A., Schocker, Nathaniel S., Michael, Katja

“…β-Configured peracetylated sugars are often used as easily accessible glycosyl donors that are typically activated with common Lewis acids such as boron…”
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Corrigendum to “A high-yielding synthesis of allyl glycosides from peracetylated glycosyl donors” [Carbohydr. Res. 357 (2012) 147–150] by Khamsi, Jamal, Ashmus, Roger A., Schocker, Nathaniel S., Michael, Katja

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