Search Results - "Ashley, Richard H"

S100A4 and Bone Morphogenetic Protein-2 Codependently Induce Vascular Smooth Muscle Cell Migration via Phospho–Extracellular Signal-Regulated Kinase and Chloride Intracellular Channel 4 by Spiekerkoetter, Edda, Guignabert, Christophe, de Jesus Perez, Vinicio, Alastalo, Tero-Pekka, Powers, Janine M, Wang, Lingli, Lawrie, Allan, Ambartsumian, Noona, Schmidt, Ann-Marie, Berryman, Mark, Ashley, Richard H, Rabinovitch, Marlene

“…RATIONALE:S100A4/Mts1 is implicated in motility of human pulmonary artery smooth muscle cells (hPASMCs), through an interaction with the RAGE (receptor for…”
Get full text

CLIC4 (p64H1) and its putative transmembrane domain form poorly selective, redox-regulated ion channels by Singh, Harpreet, Ashley, Richard H

“…Despite being synthesized in the cytosol without a leader sequence, the soluble 253-residue mammalian protein CLIC4 (Chloride Intracellular Channel 4, or…”
Get more information

Surface expression, single-channel analysis and membrane topology of recombinant Chlamydia trachomatis Major Outer Membrane Protein by Findlay, Heather E, McClafferty, Heather, Ashley, Richard H

“…Chlamydial bacteria are obligate intracellular pathogens containing a cysteine-rich porin (Major Outer Membrane Protein, MOMP) with important structural and,…”
Get full text

Neutron diffraction reveals sequence-specific membrane insertion of pre-fibrillar islet amyloid polypeptide and inhibition by rifampicin by Balali-Mood, Kia, Ashley, Richard H., Hauß, Thomas, Bradshaw, Jeremy P.

“…Human islet amyloid polypeptide (hIAPP) forms amyloid deposits in non-insulin-dependent diabetes mellitus (NIDDM). Pre-fibrillar hIAPP oligomers (in contrast…”
Get full text

Redox Regulation of CLIC1 by Cysteine Residues Associated with the Putative Channel Pore by Singh, Harpreet, Ashley, Richard H.

“…Chloride intracellular channels (CLICs) are putative pore-forming glutathione-S-transferase homologs that are thought to insert into cell membranes directly…”
Get full text

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles by JANSON, J, ASHLEY, R. H, HARRISON, D, MCINTYRE, S, BUTLER, P. C

“…The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles. J Janson , R H Ashley , D Harrison ,…”
Get full text

Pregnant rat myometrial cells show heterogeneous ryanodine- and caffeine-sensitive calcium stores by Martin, C, Hyvelin, J M, Chapman, K E, Marthan, R, Ashley, R H, Savineau, J P

“…Intracellular Ca(2+) release channels such as ryanodine receptors play crucial roles in the Ca(2+)-mediated signaling that triggers excitation-contraction…”
Get full text

Autoinsertion of soluble oligomers of Alzheimer's A beta (1-42) peptide into cholesterol-containing membranes is accompanied by relocation of the sterol towards the bilayer surface by Ashley, Richard H, Harroun, Thad A, Hauss, Thomas, Breen, Kieran C, Bradshaw, Jeremy P

“…Soluble Alzheimer's A beta oligomers autoinsert into neuronal cell membranes, contributing to the pathology of Alzheimer's Disease (AD), and elevated serum…”
Get full text

Inhibitors can arrest the membrane activity of human islet amyloid polypeptide independently of amyloid formation by Harroun, Thad A., Bradshaw, Jeremy P., Ashley, Richard H.

“…Human islet amyloid polypeptide (hIAPP), co-secreted with insulin from pancreatic β cells, misfolds to form amyloid deposits in non-insulin-dependent diabetes…”
Get full text

Rat Brain p64H1, Expression of a New Member of the p64 Chloride Channel Protein Family in Endoplasmic Reticulum by Duncan, Rory R., Westwood, Paul K., Boyd, Alan, Ashley, Richard H.

“…Many plasma membrane Cl−channels have been cloned, including the cystic fibrosis transmembrane conductance regulator and several members of the voltage-gated…”
Get full text

Functional reconstitution, gene isolation and topology modelling of porins from Burkholderia pseudomallei and Burkholderia thailandensis by Siritapetawee, Jaruwan, Prinz, Heino, Samosornsuk, Worada, Ashley, Richard H, Suginta, Wipa

“…The sequences for Omp38 from Burkholderia pseudomallei and Burkholderia thailandensis have been deposited in the DDBJ, EMBL, GenBank(R) and GSDB Nucleotide…”
Get full text

major outer membrane protein of Chlamydia psittaci functions as a porin-like ion channel by Wyllie, S, Ashley, R.H, Longbottom, D, Herring, A.J

“…The major outer membrane protein (MOMP) of Chlamydia species shares several biochemical properties with classical porin proteins. Secondary structure analysis…”
Get full text

Clostridium perfringens type A enterotoxin forms mepacrine-sensitive pores in pure phospholipid bilayers in the absence of putative receptor proteins by Hardy, Simon P, Ritchie, Christie, Allen, Marcus C, Ashley, Richard H, Granum, Per Einar

“…Clostridium perfringens enterotoxin (CPE) is an important cause of food poisoning with no significant homology to other enterotoxins and its mechanism of…”
Get full text

Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms by SUGINTA, Wipa, KAROULIAS, Nikolaos, AITKEN, Alastair, ASHLEY, Richard H.

“…Mammalian chloride intracellular channel (CLIC) (p64-related) proteins are widely expressed, with an unusual dual localization as both soluble and integral…”
Get full text

Molecular cloning and developmental expression of two Chloride Intracellular Channel (CLIC) genes in Xenopus laevis by Shorning, Boris Y, Wilson, Duncan B, Meehan, Richard R, Ashley, Richard H

“…CLIC proteins are components or regulators of novel intracellular anion channels in mammalian cells, and previous studies have suggested that human nuclear…”
Get full text

Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms by Suginta, W, Karoulias, N, Aitken, A, Ashley, R H

“…Mammalian chloride intracellular channel (CLIC) (p64-related) proteins are widely expressed, with an unusual dual localization as both soluble and integral…”
Get full text

The structure, function, and cellular regulation of ryanodine-sensitive Ca2+ release channels by Shoshan-Barmatz, V, Ashley, R H

“…The fundamental biological process of Ca2+ signaling is known to be important in most eukaryotic cells, and inositol 1,2,5-trisphosphate and ryanodine…”
Get more information

S100A4 and BMP-2 Co-Dependently Induce Vascular Smooth Muscle Cell Migration via pERK and Chloride Intracellular Channel 4 (CLIC4) by Spiekerkoetter, Edda, Guignabert, Christophe, de Jesus Perez, Vinicio, Alastalo, Tero-Pekka, Powers, Janine M, Wang, Lingli, Lawrie, Allan, Ambartsumian, Noona, Schmidt, Ann-Marie, Berryman, Mark, Ashley, Richard H, Rabinovitch, Marlene

Get full text

Latrophilin, Neurexin, and Their Signaling-deficient Mutants Facilitate α-Latrotoxin Insertion into Membranes but Are Not Involved in Pore Formation by Volynski, Kirill E., Meunier, Frédéric A., Lelianova, Vera G., Dudina, Ekaterina E., Volkova, Tatyana M., Rahman, M. Atiqur, Manser, Catherine, Grishin, Eugene V., Dolly, J. Oliver, Ashley, Richard H., Ushkaryov, Yuri A.

“…Pure α-latrotoxin is very inefficient at forming channels/pores in artificial lipid bilayers or in the plasma membrane of non-secretory cells. However, the…”
Get full text

Changes in the expression of myometrial ryanodine receptor mRNAs during human pregnancy by Martin, Cécile, Chapman, Karen E., Thornton, Steven, Ashley, Richard H.

“…Uterine contraction is triggered by a rise in intracellular free Ca 2+ concentration ([Ca 2+] i), and although ryanodine-sensitive Ca 2+ release channels…”
Get full text