Search Results - "Ashley, Rachel"
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Activities of gyrase and topoisomerase IV on positively supercoiled DNA
Published in Nucleic acids research (19-09-2017)“…Although bacterial gyrase and topoisomerase IV have critical interactions with positively supercoiled DNA, little is known about the actions of these enzymes…”
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Natural Products as Topoisomerase II Poisons: Effects of Thymoquinone on DNA Cleavage Mediated by Human Topoisomerase IIα
Published in Chemical research in toxicology (19-05-2014)“…The seeds of Nigella sativa (often referred to as black seed) have long been utilized as a medicinal herb in Middle Eastern, Northern African, and Indian…”
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Evidence for a role of viruses in the thermal sensitivity of coral photosymbionts
Published in The ISME Journal (01-03-2017)“…Symbiodinium , the dinoflagellate photosymbiont of corals, is posited to become more susceptible to viral infections when heat-stressed. To investigate this…”
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Oxidative Transformation of Demethoxy- and Bisdemethoxycurcumin: Products, Mechanism of Formation, and Poisoning of Human Topoisomerase IIα
Published in Chemical research in toxicology (18-05-2015)“…Extracts from the rhizome of the turmeric plant are widely consumed as anti-inflammatory dietary supplements. Turmeric extract contains the three curcuminoids,…”
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Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase
Published in Biochemistry (Easton) (10-10-2017)“…Mycobacterium tuberculosis encodes only a single type II topoisomerase, gyrase. As a result, this enzyme likely carries out the cellular functions normally…”
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Interactions between Quinolones and Bacillus anthracis Gyrase and the Basis of Drug Resistance
Published in Biochemistry (Easton) (15-08-2017)“…Gyrase appears to be the primary cellular target for quinolone antibacterials in multiple pathogenic bacteria, including Bacillus anthracis, the causative…”
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Catalytic Core of Human Topoisomerase IIα: Insights into Enzyme–DNA Interactions and Drug Mechanism
Published in Biochemistry (Easton) (21-10-2014)“…Coordination between the N-terminal gate and the catalytic core of topoisomerase II allows the proper capture, cleavage, and transport of DNA during the…”
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Barriers driving health care disparities in utilization of age-appropriate screening
Published in Frontiers in public health (03-03-2023)Get full text
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Synthesis and evaluation of ether-linked demethylepipodophyllotoxin dimers
Published in Bioorganic & medicinal chemistry letters (15-12-2014)“…A series of novel ether-linked dimers of demethylepipodophyllotoxin are topoisomerase II poisons that exhibit higher levels of double-stranded versus…”
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Miss Monstress: The Trial of Womanhood and Rhetorical Framing of Texas Women on Trial for Murder
Published 01-01-2024“…This dissertation is a rhetorical analysis of the cases of three Texas women who were charged with murder. I examine the rhetoric used by the media and the…”
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Dissertation -
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Starting a Long Acting Reversible Contraception Training Program in an Adolescent Medicine Fellowship
Published in Journal of adolescent health (01-02-2018)Get full text
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210 - Starting a Long Acting Reversible Contraception Training Program in an Adolescent Medicine Fellowship
Published in Journal of adolescent health (01-02-2018)Get full text
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Academic Outreach and Collaboration with Community Oncology Practices to Enhance Referrals and Reduce Disparities in Hematological Malignancies
Published in Blood (02-11-2023)“…Introduction: Disparities in cancer care are widely reported with the reasons being multifactorial. Delays in referral and distance to travel along with lack…”
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Bortezomib Induced Peripheral and Severe Autonomic Neuropathy Characterized By Dizziness, Orthostatic Hypotension and Weight Loss
Published in Blood (02-11-2023)“…Background It is well known that Bortezomib (B), a proteasome inhibitor used in the treatment of Multiple Myeloma (MM) causes peripheral neuropathy in an…”
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Bortezomib Induced Peripheral and Severe Autonomic Neuropathy Characterized By Dizziness, Orthostatic Hypotension, and Weight Loss
Published in Blood (15-11-2022)Get full text
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Feasibility of a Critical Experiment Utilizing Uranium Dioxide-Beryllium Oxide with Neutron Spectrum Shifting Capabilities
Published 01-01-2022“…The goal of this project is to determine the feasibility of utilizing Annular Core Research Reactor (ACRR) fuel in core design with Sandia Pulse Reactor…”
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Planning for Seattle's Mandatory Retrofitting Policy: A Retrofitting Plan for the Northern Pacific Hotel
Published 01-01-2019“…A retrofitting resource for the NP Hotel focusing on retrofitting methods and funding options…”
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Dissertation -
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Microfluidic chambers used to test whether episodic breathing is regulated by the pons in turtle brainstems
Published in The FASEB journal (01-04-2010)“…Our goal is to locate and characterize neurons controlling respiratory motor burst timing. Episodic breathing (clusters of fictive breaths separated by apneas)…”
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LBA13 - Academic Center Outreach to Community Practices Increases Transplant Referrals and Possibly Reduce Racial Disparities
Published in Transplantation and cellular therapy (01-03-2022)Get full text
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