Search Results - "Ashley, Jason W."

Cellular biology of fracture healing by Bahney, Chelsea S., Zondervan, Robert L., Allison, Patrick, Theologis, Alekos, Ashley, Jason W., Ahn, Jaimo, Miclau, Theodore, Marcucio, Ralph S., Hankenson, Kurt D.

“…ABSTRACT The biology of bone healing is a rapidly developing science. Advances in transgenic and gene‐targeted mice have enabled tissue and cell‐specific…”
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Calcium-independent phospholipases A2 and their roles in biological processes and diseases by Ramanadham, Sasanka, Ali, Tomader, Ashley, Jason W., Bone, Robert N., Hancock, William D., Lei, Xiaoyong

“…Among the family of phospholipases A2 (PLA2s) are the Ca2+-independent PLA2s (iPLA2s) and they are designated group VI iPLA2s. In relation to secretory and…”
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Notch Signaling Promotes Osteoclast Maturation and Resorptive Activity by Ashley, Jason W., Ahn, Jaimo, Hankenson, Kurt D.

“…ABSTRACT The role of Notch signaling in osteoclast differentiation is controversial with conflicting experimental evidence indicating both stimulatory and…”
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c-Src Links a RANK/αvβ3 Integrin Complex to the Osteoclast Cytoskeleton by Izawa, Takashi, Zou, Wei, Chappel, Jean C., Ashley, Jason W., Feng, Xu, Teitelbaum, Steven L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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RANK signaling in osteoclast precursors results in a more permissive epigenetic landscape and sexually divergent patterns of gene expression by Keever, Abigail L, Collins, Kathryn M, Clark, Rachel A, Framstad, Amber L, Ashley, Jason W

“…Sex is an important risk factor in the development of osteoporosis and other bone loss disorders, with women often demonstrating greater susceptibility than…”
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Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts by Ashley, Jason W, Shi, Zhenqi, Zhao, Haibo, Li, Xingsheng, Kesterson, Robert A, Feng, Xu

“…CD68 is a member of the lysosome associated membrane protein (LAMP) family that is restricted in its expression to cells of the monocyte/macrophage lineage…”
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Notch signaling inhibition protects against LPS mediated osteolysis by Goel, Peeyush N., Egol, Alexander J., Moharrer, Yasaman, Brandfield-Harvey, Beatrix, Ahn, Jaimo, Ashley, Jason W.

“…Chronic inflammatory responses have profound effects on the differentiation and activity of both the bone-forming osteoblasts and bone-resorbing osteoclasts…”
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Bone healing in an aged murine fracture model is characterized by sustained callus inflammation and decreased cell proliferation by Hebb, John H., Ashley, Jason W., McDaniel, Lee, Lopas, Luke A., Tobias, John, Hankenson, Kurt D., Ahn, Jaimo

“…ABSTRACT Geriatric fractures take longer to heal and heal with more complications than those of younger patients; however, the mechanistic basis for this…”
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Selective targeting of RANK signaling pathways as new therapeutic strategies for osteoporosis by Jules, Joel, Ashley, Jason W, Feng, Xu

“…Osteoporosis has become a worldwide health and social issue due to an aging population. Four major antiresorptive drugs (agents capable of inhibiting…”
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Suppression of Notch Signaling in Osteoclasts Improves Bone Regeneration and Healing by Goel, Peeyush N., Moharrer, Yasaman, Hebb, John H., Egol, Alexander J., Kaur, Gurpreet, Hankenson, Kurt D., Ahn, Jaimo, Ashley, Jason W.

“…ABSTRACT Owing to the central role of osteoclasts in bone physiology and remodeling, manipulation of their maturation process provides a potential therapeutic…”
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Molecular Basis of Requirement of Receptor Activator of Nuclear Factor κB Signaling for Interleukin 1-mediated Osteoclastogenesis by Jules, Joel, Zhang, Ping, Ashley, Jason W., Wei, Shi, Shi, Zhenqi, Liu, Jianzhong, Michalek, Suzanne M., Feng, Xu

“…IL-1, a proinflammatory cytokine, is implicated in bone loss in various pathological conditions by promoting osteoclast formation, survival, and function…”
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Extracellular Matrix and Adhesion Molecule Gene Expression in the Normal and Injured Murine Intervertebral Disc by Zhang, Yejia, Tian, Zuozhen, Ashley, Jason W, Wang, Luqiang, Tower, Robert J, Wei, Yulong, Qin, Ling, Yang, Shuying, Enomoto-Iwamoto, Motomi

“…OBJECTIVEThe aim of the study was to determine the transcription profile of the mouse nucleus pulposus and annulus fibrosus with an unbiased method…”
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors by Kaur, Gurpreet, Ahn, Jaimo, Hankenson, Kurt D, Ashley, Jason W

“…Notch signaling is a key component of multiple physiological and pathological processes. The nature of Notch signaling, however, makes in vitro investigation…”
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Polarization of Macrophages toward M2 Phenotype Is Favored by Reduction in iPLA2β (Group VIA Phospholipase A2) by Ashley, Jason W., Hancock, William D., Nelson, Alexander J., Bone, Robert N., Tse, Hubert M., Wohltmann, Mary, Turk, John, Ramanadham, Sasanka

“…Macrophages are important in innate and adaptive immunity. Macrophage participation in inflammation or tissue repair is directed by various extracellular…”
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Intervertebral disc development and disease-related genetic polymorphisms by Ashley, Jason W., Enomoto-Iwamoto, Motomi, Smith, Lachlan J., Mauck, Robert L., Chan, Danny, Lee, Joseph, Heyworth, Martin F., An, Howard, Zhang, Yejia

“…The intervertebral disc (IVD) comprises a gelatinous inner core (nucleus pulposus; NP) and concentric rings (annulus fibrosus; AF). The NP, an important…”
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Expression of osteoprotegerin from a replicating adenovirus inhibits the progression of prostate cancer bone metastases in a murine model by Cody, James J, Rivera, Angel A, Lyons, Gray R, Yang, Sherry W, Wang, Minghui, Ashley, Jason W, Meleth, Sreelatha, Feng, Xu, Siegal, Gene P, Douglas, Joanne T

“…Metastatic involvement of the skeleton is a frequent consequence of advanced prostate cancer. These skeletal metastases cause a number of debilitating…”
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Development of cell-based high-throughput assays for the identification of inhibitors of receptor activator of nuclear factor-kappa B signaling by Ashley, Jason W, McCoy, Erin M, Clements, Daniel A, Shi, Zhenqi, Chen, Taosheng, Feng, Xu

“…Bone loss due to metabolic or hormonal disorders and osteolytic tumor metastasis continues to be a costly health problem, but current therapeutics offer only…”
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors by Kaur, Gurpreet, Ahn, Jaimo, Hankenson, Kurt D., Ashley, Jason W.

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Novel effects of Brefeldin A (BFA) in signaling through the insulin receptor (IR) pathway and regulating FoxO1-mediated transcription by Wyrozumska, Paulina, Ashley, Jason W, Ramanadham, Sasanka, Liu, Qinglan, Garvey, W Timothy, Sztul, Elizabeth

“…Brefeldin A (BFA) is a fungal metabolite best known for its ability to inhibit activation of ADP-ribosylation factor (Arf) and thereby inhibit secretory…”
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